Kai Wing Kevin Tang

Skin-attached bioadhesive patch enabling ultrasound deep brain stimulation and real-time electrophysiological monitoring for REM sleep enhancement

Kai Wing Kevin Tang, Benjamin Baird, William D. Moscoso-Barrera, Mengxia Yu et autres

Wearable bioelectronic interfaces capable of simultaneous neural sensing and targeted deep brain modulation remain limited by the lack of non-invasive technologies with sufficient spatial precision and mechanical stability for continuous operation. Here we report NEUSLeeP, a flexible skin-attached bioadhesive patch integrating electrophysiological …

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Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats

Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang et autres

ABSTRACT Ultrasound‐triggered mechanoluminescence has emerged as a promising strategy for non‐invasive light delivery, enabling remote neuromodulation that advances optogenetics and accelerates its clinical translation. However, existing mechanoluminescent nanotransducers lack sufficient brightness and durable, repeatable emission to effectively modulate brain function in deep …

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Multicolored, Sonosensitizer-Optimized Organic Mechanoluminescent Nanoparticles for Functional Sono-Optogenetics

Xiangping Liu, Wenliang Wang, Brinkley Artman, Jiefeng Diao et autres

Light enables precise visualization and control of cellular processes, but its utility in deep tissues is fundamentally limited by poor optical penetration, particularly in the deep brain. Ultrasound-triggered mechanoluminescence offers a noninvasive strategy for remote light delivery, yet existing organic systems remain …

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Multicolored, Sonosensitizer-optimized Organic Mechanoluminescent Nanoparticles for Functional Sono-optogenetics

Xiangping Liu, Wang Wenliang, Brinkley Artman, Jiefeng Diao et autres

Light enables precise visualization and control of cellular processes, but its utility in deep tissues is fundamentally limited by poor optical penetration, particularly in the deep brain. Ultrasound-triggered mechanoluminescence offers a non-invasive strategy for remote light delivery, yet existing organic systems remain …

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Fully Wearable Armband for Long-Term Peripheral Ultrasound Neuromodulation in Pain Management

William D. Moscoso-Barrera, Yiming Han, Jinmo Jeong, QiLiang Chen et autres

Abstract Chronic pain is a leading cause of medical consultations, often managed with opioids despite their high risk of addiction. Low-Intensity Focused Ultrasound (LIFU) neuromodulation has emerged as a promising non- invasive alternative for pain management. However, effective pain modulation often requires …

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Wearable Focused Ultrasound Neuromodulation and Electrophysiological Recording Patch for REM Sleep Enhancement

Kai Wing Kevin Tang, Benjamin Baird, William D. Moscoso-Barrera, Mengxia Yu et autres

Abstract The rise in sleep disease affecting the general population globally in the past decade has been detrimental to individually and socioeconomically. As of now, approaches often are temporary through medication, permanently using invasive implants with surgical complications or neuromodulation therapy. However, …

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Postprocessing-Enhanced Machine Learning for Reliable Real-Time Sleep Staging in Closed-Loop Neuromodulation

Tony Sungjin Chae, Jinmo Jeong, Kai Wing Kevin Tang, William D. Moscoso-Barrera et autres

Abstract Real-time sleep stage classification is important for closed-loop neuromodulation at certain stages during sleep, yet current models often yield noisy and unstable outputs that risk false triggers. These fluctuations, especially near stage boundaries, can compromise the safety and reliability of stimulation. …

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A machine-learning-guided hydrogen-bonded organic framework for long-term, ultrasound-triggered pain therapy

Weilong He, Xi Shi, Yanxing Wang, Wenliang Wang et autres

Abstract Effective treatment of chronic pain remains hindered by the lack of drug delivery systems that simultaneously achieve long-term stability, high spatial precision, and non-invasiveness 1,2,3 . Here, we utilize a programmable, ultrasound-responsive drug delivery platform based on hydrogen-bonded organic framework (HOF) …

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Bioadhesive hydrogel-coupled and miniaturized ultrasound transducer system for long-term, wearable neuromodulation

Kai Wing Kevin Tang, Jinmo Jeong, Ju-Chun Hsieh, Mengmeng Yao et autres

Transcranial focused ultrasound is a promising non-invasive method for neuromodulation, particularly for neurodegenerative and psychiatric conditions. However, its use in wearable systems has been limited due to bulky devices and reliance on ultrasound gel, which dehydrates and lacks stable adhesion for long-term …

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Stretchable, hair-compatible, and long-term stable wearable EEG system

Ju-Chun Hsieh, Mengmeng Yao, Hussein Alawieh, Victoria Koptelova et autres

Abstract Electroencephalography (EEG) is a cornerstone in both neuroscience research and clinical diagnostics. However, conventional EEG monitoring faces hardware limitations, particularly its adaptability and stability. Headsets either require complicated wiring or do not have enough stretchability and wearability to comply with the …

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H-bonded organic frameworks as ultrasound-programmable delivery platform

Wenliang Wang, Yanshu Shi, Wenrui Chai, Kai Wing Kevin Tang et autres

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Hydrogen-bonded organic framework nanotransducers enabled sono-optogenetics for Parkinsonian rats

Wenliang Wang, Ilya Pyatnitskiy, Yanshu Shi, Kai Wing Kevin Tang et autres

Cell-type-specific activation of parvalbumin (PV)-expressing neurons in the external globus pallidus (GPe) through optogenetics has shown promise in facilitating long-lasting movement dysfunction recovery in mice with Parkinson's disease. However, its translational potential is hindered by adverse effects stemming from the invasive implantation …

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