Rosa Peltrini

Eosinophil-derived breath biomarkers and response to anti–IL-5/5R biologics in severe asthma

Thibault Massenet, Pierre‐Hugues Stefanuto, Rosa Peltrini, R L Cordell et autres

be, gb, us, nl (code pays fourni par la source)

Broadly cross-reactive mRNA COVID-19 vaccine encoding trimeric RBDs and NSP12 mitigates immune imprinting

Arianna De Chiara, Caterina Giachino, Maria Franca Pirillo, Andrea Campanile et autres

The continuous evolution of SARS-CoV-2 variants, driven by mutations in the spike protein undermines viral recognition by antibodies elicited through prior infection or vaccination with the ancestral Wuhan strain. Original antigenic sin of SARS-CoV-2 ancestral virus or vaccine led to a weakened …

gb, it (code pays fourni par la source)

Structural and cellular properties of human prion protein oligomers

Alessandro Emendato, Giuseppina Divisato, Emilia Giannino, Silvia Mansueto et autres

The misfolding of the human prion protein (hPrP) and the consequent self-assembly into insoluble amyloid fibrils are associated with neurodegenerative diseases known as transmissible spongiform encephalopathies (TSEs). In this study, we investigated the stability and aggregation behaviour of the folded C-terminal domain …

it (code pays fourni par la source)

Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma

Rosa Peltrini, Rebecca L. Cordell, Michael J. Wilde, Shahd Abuhelal et autres

Abstract Rationale Volatile organic compounds (VOCs) in asthmatic breath may be associated with sputum eosinophilia. We developed a volatile biomarker signature to predict sputum eosinophilia in asthma. Methods VOCs emitted into the space above sputum samples (headspace) from patients with severe asthma …

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Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson’s disease

Tony Oosterveen, Pedro Garção, Emma Moles-Garcia, Clément Soleilhavoup et autres

In Parkinson's disease (PD), substantia nigra (SN) dopaminergic (DA) neurons degenerate, while related ventral tegmental area (VTA) DA neurons remain relatively unaffected. Here, we present a methodology that directs the differentiation of mouse and human pluripotent stem cells toward either SN- or …

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Volatile organic compounds in a headspace sampling system and asthmatics sputum samples

Rosa Peltrini, Rebecca L. Cordell, Wadah Ibrahim, Michael J. Wilde et autres

-scores, with the exclusion of benzothiazole, whose abundance increased linearly between 11am and 3pm with a maximal intra-day fold change of 2.13. Many of the identified background features are reported in literature as components of headspace of biological samples and are considered …

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Liposome-Embedding Silicon Microparticle for Oxaliplatin Delivery in Tumor Chemotherapy

Armando Cevenini, Christian Celia, Stefania Orrù, Daniela Sarnataro et autres

Mesoporous silicon microparticles (MSMPs) can incorporate drug-carrying nanoparticles (NPs) into their pores. An NP-loaded MSMP is a multistage vector (MSV) that forms a Matryoshka-like structure that protects the therapeutic cargo from degradation and prevents its dilution in the circulation during delivery to …

it, us, gb, ru (code pays fourni par la source)

Assessment of breath volatile organic compounds in acute cardiorespiratory breathlessness: a protocol describing a prospective real-world observational study

Wadah Ibrahim, Michael J. Wilde, Rebecca L. Cordell, Dahlia Salman et autres

INTRODUCTION: Patients presenting with acute undifferentiated breathlessness are commonly encountered in admissions units across the UK. Existing blood biomarkers have clinical utility in distinguishing patients with single organ pathologies but have poor discriminatory power in multifactorial presentations. Evaluation of volatile organic compounds …

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