Toshio Sofuni

Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT)

Stefan Pfuhler, Jan van Benthem, Rodger Curren, Shareen Heather Doak et autres

Use of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress has been made with establishing robust protocols for skin, …

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Evolution of genotoxicity test methods in Japan

Toshio Sofuni

The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of Japan (at that time) organized a research group …

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Practical issues on the application of the GHS classification criteria for germ cell mutagens

Takeshi Morita, Makoto Hayashi, Madoka Nakajima, Noriho Tanaka et autres

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Molecular anatomy of human chromosome 9: comparative mapping of the immunoglobulin processed pseudogene Cε3 (IGHEP2) in primates

Hideyuki Tanabe, Tomoko Ishida, Shintaroh Ueda, Toshio Sofuni et autres

Karyotypic homology in relation to human chromosome 9 (HSA 9) was studied through comparative mapping of the immunoglobulin-processed pseudogene C epsilon 3 (IGHEP2) in primates. IGHEP2, which has been mapped to 9p24.2 --> p24.1 in the human genome, was assigned to PTR …

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Comparative mapping of the immunoglobulin Cε1 gene (IGHE) in five species of nonhuman primates by fluorescence in situ hybridization

Hideyuki Tanabe, Tomoko Ishida, Shintaroh Ueda, Toshio Sofuni et autres

The orthologous immunoglobulin C epsilon 1 gene (IGHE) of the common chimpanzee, pygmy chimpanzee, orangutan, white-handed gibbon, and Japanese macaque was assigned to the human chromosome 14 homologue in each species and regionally mapped by fluorescence in situ hybridization to PTR15q32 (common …

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Contents, Vol. 70, 1995

M. Banzai, K. Omoe, H. Ishikawa, Anna Endo et autres

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Subject Index, Vol. 70, 1995

M. Banzai, K. Omoe, Hidetoshi Ishikawa, Anna Endo et autres

Regional assignment of the human immunoglobulin processed pseudogene Cε3 (IGHEP2) to 9p24.2→p24.1 by fluorescence in situ hybridization

Hideyuki Tanabe, Takashi Ishida, Shintaroh Ueda, Toshio Sofuni et autres

The human immunoglobulin processed pseudogene C epsilon 3 (IGHEP2), which was assigned to chromosome 9 by somatic cell hybrid analysis, has not been regionally localized as yet. In this study, using fluorescence in situ hybridization (FISH) combined with conventional QFQ-, RBG- or …

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Characteristic karyotype abnormalities including Robertsonian translocations found in eight mouse embryonic stem cell lines

Ayako Sugawara, Kazuo Gotō, Toshio Sofuni, Akira Takakura

Clastogenicity of Quinoline and Monofluorinated Quinolines in Chinese Hamster Lung Cells

Takayoshi Suzuki, Kenji Takeshita, Ken‐ichi Saeki, Minoru Kadoi et autres

Quinoline and four monofluorinated derivatives of quinoline (FQ's) were tested for their clastogenicity in a Chinese hamster lung (CHL) cell line using chromosomal aberration (CA) and micronucleus (MN) tests.Quinoline and all the fluoroquinolines, 3-, 5-, 6-, and 8-FQ, induced CA in the …

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Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests

David J. Tweats, David H. Blakey, Robert H. Heflich, Abby Jacobs et autres

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Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests

David J. Tweats, David H. Blakey, Robert H. Heflich, Abigail C. Jacobs et autres

gb, ca, us, dk, jp (code pays fourni par la source)