Gerhard M. Kostner

Sex-Related Differences in the Associations between Adiponectin and Serum Lipoproteins in Healthy Subjects and Patients with Metabolic Syndrome

Iva Klobučar, Hansjörg Habisch, Lucija Klobučar, Matias Trbušić et autres

The strong associations between the serum levels of adiponectin and the lipoprotein subclasses observed in healthy subjects are much weaker in patients with metabolic syndrome (MS). However, the impact of sex on these associations remained unexplored. Therefore, in the present study, we …

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Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome

Iva Klobučar, Hansjörg Habisch, Lucija Klobučar, Matias Trbušić et autres

Metabolic syndrome (MS) is a widespread disease in developed countries, accompanied, among others, by decreased adiponectin serum levels and perturbed lipoprotein metabolism. The associations between the serum levels of adiponectin and lipoproteins have been extensively studied in the past under healthy conditions, …

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The 10 essential questions regarding lipoprotein(a)

Karam Kostner, Gerhard M. Kostner

PURPOSE OF REVIEW: Lp(a) is one of the most atherogenic lipoproteins, and significant progress has been made to understand its pathophysiology over the last 20 years. There are now selective therapies in late-stage clinical trials to lower Lp(a). Yet there are many …

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Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Stephen Zewinger, Jochen Reiser, Vera Jankowski, Dalia Alansary et autres

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Review of: "Why Non-HDL Cholesterol is Preferred over Apolipoprotein B-100 (Apo B)"

Gerhard M. Kostner

Development of an LC-MRM-MS-Based Candidate Reference Measurement Procedure for Standardization of Serum Apolipoprotein (a) Tests

L. Renee Ruhaak, Fred P.H.T.M. Romijn, Ilijana Begcevic Brkovic, Zsusanna Kuklenyik et autres

BACKGROUND: Medical results generated by European CE Marking for In Vitro Diagnostic or in-house tests should be traceable to higher order reference measurement systems (RMS), such as International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)-endorsed reference measurement procedures (RMPs) and reference …

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Commutability Assessment of Candidate Reference Materials for Lipoprotein(a) by Comparison of a MS-based Candidate Reference Measurement Procedure with Immunoassays

Ioannis Dikaios, Harald Althaus, Eduardo Anglés‐Cano, Uta Ceglarek et autres

BACKGROUND: Elevated concentrations of lipoprotein(a) [Lp(a)] are directly related to an increased risk of cardiovascular diseases, making it a relevant biomarker for clinical risk assessment. However, the lack of global standardization of current Lp(a) measurement procedures (MPs) leads to inconsistent patient care. …

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Lipoprotein(a)

Karam Kostner, Gerhard M. Kostner, Peter P. Tóth

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Unresolved Questions

Gerhard M. Kostner, Karam Kostner

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Lp(a) Biochemistry, Composition, and Structure

Gerhard M. Kostner

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Lipoprotein(a): Metabolism, Pathophysiology, and Impact on Diabetes Mellitus

Karam Kostner, Gerhard M. Kostner

Lp(a) belongs to the cholesterol ester rich, apoB containing lipoproteins, yet its metabolism is distinct from that of LDL. Details of apo(a) metabolism are slowly beginning to unravel. The concentration of plasma Lp(a) is to >90% inherited where the best studied kringle-4 …

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Towards an SI-traceable reference measurement system for serum apolipoproteins (A), A-I, B, C-I, C-II, C-III and E

L. Renee Ruhaak, Fred P.H.T.M. Romijn, I. Begcevic-Brkovic, Zsuzsanna Kuklenyik et autres

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