Anne Ortved Gang

Comprehensive longitudinal profiling identifies differential frequency, epitope specificity, and effector function of CD8+ T-cells across COVID-19 disease severities

Susana Patricia Amaya Hernandez, Kamilla Kjærgaard Munk, Konstantin Danilov, Mohammad Kadivar et autres

BACKGROUND: T-cells are crucial for controlling and resolving SARS-CoV-2 infection, yet their epitope specificity and relationship to COVID-19 disease severity remain incompletely understood. METHODS: T-cell populations using DNA-barcoded peptide-HLA multimers, analysing 553 SARS-CoV-2 epitopes across globally prevalent HLA alleles in patients with …

dk (code pays fourni par la source)

Unusually long remission in two patients with follicular lymphoma receiving immunomodulating therapeutic cancer vaccines

Morten Orebo Holmström, Shamaila Munir Ahmad, Uffe Klausen, Mads Emil Bjørn et autres

The immune checkpoints programmed death-ligand (PD-L)1 and PD-L2 are expressed in follicular lymphoma (FL), yet immune checkpoint blocking antibodies have failed in FL. We previously initiated a phase I immune modulating vaccination (IMV) trial targeting PD-L1 and PD-L2 in patients with advanced …

dk (code pays fourni par la source)

Validation of US Consensus Eligibility Criteria for Front‐Line DLBCL Trials

Jelena Jelicic, Karen Juul‐Jensen, Zoran Bukumirić, Rasmus Rask Kragh Jørgensen et autres

Identifying patients eligible for front-line clinical trials with diffuse large B-cell lymphoma (DLBCL) has been challenging, primarily due to increasingly stringent inclusion criteria and the limitations of the International Prognostic Indices in identifying patients who are unlikely to achieve long-term remission after …

dk, rs (code pays fourni par la source)

Novel immune gene expression signature risk-stratifies Mantle Cell Lymphoma outcomes independent of TP53 status

Jean Louise Koff, Veronica S. Russell, Rachel Kositsky, David L. Jaye et autres

Abstract Background: The prognostic impact of specific genomic changes in mantle cell lymphoma (MCL) is not well characterized beyond altered TP53, which is recognized as a high-risk marker and commonly assessed at diagnosis, and the “proliferation signature” developed using gene expression in …

us, gb, fi, dk, Afrique du Sud, hk, sg, ca, qa (code pays fourni par la source)

Challenges in comparing outcomes of frontline clinical trials for diffuse large B-cell lymphoma patients selected based on the international prognostic index: A real-world analysis from the danish lymphoma registry

Jelena Jelicic, Karen Juul‐Jensen, Zoran Bukumirić, Rasmus Rask Kragh Jørgensen et autres

Abstract Background: The International Prognostic Index (IPI) has been utilized in various frontline clinical trials to identify trial-eligible patients with diffuse large B-cell lymphoma (DLBCL). However, different cut-offs have been used over the years, which may have hindered direct comparisons between trials. …

dk, rs (code pays fourni par la source)

Vaccine-induced CD8 T-cells maintain enhanced cytotoxicity and proliferation in SARS-CoV-2 breakthrough infections in hematological cancer patients 4221

Darya Trubach, Konstantin Danilov, Ditte Stampe Hersby, Anne Ortved Gang et autres

Abstract Description Despite the considerable impact of COVID-19 vaccination on protection from disease severity and mortality, SARS-CoV-2 breakthrough infections are substantially high in patients with hematological cancers. This could be attributed to the impaired antibody response in this group of patients. Thus, …

dk (code pays fourni par la source)

Comprehensive longitudinal profiling of SARS-CoV-2 antigens reveals COVID-19 severity-associated CD8+ T-cell activation and functional impairment 3496

Susana Patricia Amaya Hernandez, Kamilla Kjærgaard Munk, Konstantin Danilov, Mohammad Kadivar et autres

Abstract Description CD8+ T-cells are crucial for resolving SARS-CoV-2 infection. However, the persistence of SARS-CoV-2 epitope-specific CD8+ T-cell responses post-infection and their impact on COVID-19 pathogenesis remain unclear due to limited epitope-specific resolution. Using DNA-barcoded peptide-major histocompatibility complex (pMHC) multimers, we profiled …

dk (code pays fourni par la source)

Uncovering the role of antigen-specific T cells in SARS-CoV-2 breakthrough infection 3518

Susana Patricia Amaya Hernandez, Darya Trubach, Lasse Frank Voss, Konstantin Danilov et autres

Abstract Description Breakthrough infections of SARS-CoV-2 in vaccinated individuals underscore the need to evaluate the quantitative and qualitative assessment of vaccine-induced T-cell immunity. To understand the epitope-specific CD8+ T-cell responses, we studied SARS-CoV-2 vaccinated (infection naive before vaccination) individuals up to 2 …

dk (code pays fourni par la source)

International Prognostic Models as Tools for Selection of Higher-risk Trial-eligible Patients With Diffuse Large B-Cell lymphoma

Jelena Jelicic, Karen Juul‐Jensen, Zoran Bukumirić, Mikkel Runason Simonsen et autres

BACKGROUND: The International prognostic index (IPI) is a widely used model for identifying trial-eligible patients with diffuse large B-cell lymphoma (DLBCL). However, the applicability of prognostic models in identifying trial-eligible high-intermediate (HI) and high-risk (H), particularly younger patients, has not been extensively …

dk, rs (code pays fourni par la source)

302 | PREDICTING OUTCOMES IN DIFFUSE LARGE B‐CELL LYMPHOMA PATIENTS ELIGIBLE FOR FRONT‐LINE TRIALS USING HARKINS' ENHANCED ELIGIBILITY CRITERIA

Jelena Jelicic, Karen Juul‐Jensen, Zoran Bukumirić, Rasmus Rask Kragh Jørgensen et autres

Bataillard et al. 2021) is critical for cure, but its interplay with SES and illness burden remains unexplored at the patient level.Methods: We conducted a single-center retrospective study of patients treated for DLBCL (2015)(2016)(2017)(2018)(2019)(2020)(2021)(2022)(2023)(2024) at Columbia University (New York).Neighborhood poverty rate and …

dk, rs (code pays fourni par la source)

Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 + T-cells reveal strong functional impairment and recognition bias as markers for disease severity

Susana Patricia Amaya Hernandez, Kamilla Kjærgaard Munk, Konstantin Danilov, Mohammad Kadivar et autres

Abstract CD8 + T-cells are essential for controlling and resolving SARS-CoV-2 infection, yet their antigen-specific resolution in relation to disease severity, functional dynamics during acute infection, and long-term memory formation remain incompletely understood. Using comprehensive longitudinal profiling of 553 SARS-CoV-2 immunogenic antigens …

dk (code pays fourni par la source)

NOTCH1 Mutations Are Associated With Therapy‐Resistance in Patients With B‐Cell Lymphoma Treated With CD20xCD3 Bispecific Antibodies

Emil Ramsø Kyvsgaard, Morten Grauslund, Lene Dissing Sjø, Linea Cecilie Melchior et autres

dk (code pays fourni par la source)