Holger Stephan

Data publication: Structural and Electronic Impact of Chelators on Immunoconjugates

Adam. C. Kennedy, Karl Anger, Christin Neuber, Lucca Neupert et autres

the following data are available: MS spectra of chelator L3 and its derivatives as well as their respective immunoconjugates, in vitro binding studies

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Data publication: Structural and Electronic Impact of Chelators on Immunoconjugates

Adam. C. Kennedy, Karl Anger, Christin Neuber, Lucca Neupert et autres

the following data are available: MS spectra of chelator L3 and its derivatives as well as their respective immunoconjugates, in vitro binding studies

au, de (code pays fourni par la source)

Characterization of macrocyclic host-guest systems by liquid-liquid extraction

Kazuharu Yoshizuka, Manja Kubeil, Holger Stephan

Macrocyclic compounds have advanced the molecular recognition of many organic and inorganic guest molecules, utilizing in particular their high degree of pre-organization. This has led to a number of attractive applications, for example in sensor technology, selective separation processes, and the manufacture …

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Novel immunotheranostic FAP-inhibitor target modules for imaging and elimination of FAP-positive cells by UniCAR T-cells

Hugo Boutier, Jürgen Kogler, Liliana Rodrigues Loureiro, Christin Neuber et autres

The fibroblast activation protein alpha (FAPα) is overexpressed in the tumor microenvironment of most solid cancers and, in some cases, in cancer cells, making it an interesting target for theranostic applications. T-cells modified to express a chimeric antigen receptor (CAR) against FAP …

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Epitope-Containing Cyclotides provides Radiolabelled Antibody Conjugates for Radioimmunotherapy

Adam D. Kennedy, Hugo Boutier, Manja Kubeil, Anja Feldmann et autres

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The influences of charge on the pharmacokinetic behaviour of copper-based radioimmunoconjugates

Manja Kubeil, Adam D. Kennedy, Christin Neuber, Karl Anger et autres

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Exploring Novel Copper(II) Bispidine Chelators: Modulation of Pharmacological Properties for Improved Radiopharmaceutical Approaches

Karl Anger, Adam D. Kennedy, Robert Wodtke, Michael Philipp Bachmann et autres

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Interfacing with the Brain: How Nanotechnology Can Contribute

Abdullah Ahmed Ali Ahmed, Núria Alegret, Bethany Almeida, Ramón A. Álvarez‐Puebla et autres

Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along with the available technology. Mechanical levers and cable …

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Targeted bismuth-based materials for cancer

Amna Batool, I. Kopp, Manja Kubeil, Michael Philipp Bachmann et autres

covalent modification with tumour-seeking molecules based on either small or antibody-derived molecules.

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Bismuth Oxide Nanorings: A Potential Material for Hyperthermia-Based Tumor Therapy

Amna Batool, Rebekah N. Duffin, Kirralee J. Burke, Holger Stephan et autres

Relative to bulk material, bismuth oxide nanoparticles (Bi 2 O 3 –NPs), as spheres or rods, have shown quantum confinement effects and unique optical, electrical, and magnetic properties, as well as high surface reactivity, high refractive index, good photoconductivity, and wide energy …

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Cover Feature: 64Cu tumor labeling with hexadentate picolinic acid‐based bispidine immunoconjugates (Chem. Eur. J. 32/2024)

Manja Kubeil, Christin Neuber, Miriam Starke, Claudia Arndt et autres

Bispidine picolinates quickly form very stable complexes with the positron emitter 64CuII under physiological conditions. These bifunctional chelators can be easily attached to amino-terminated tumor-seeking target modules. The subsequent 64Cu labeling is fast and efficient, and does not require demanding purification steps. …

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64Cu tumor labeling with hexadentate picolinic acid‐based bispidine immunoconjugates

Manja Kubeil, Christin Neuber, Miriam Starke, Claudia Arndt et autres

Abstract Discussed are two picolinate appended bispidine ligands (3,7‐diazabicyclo[3.3.1]nonane derivatives) in comparison with an earlier described bis‐pyridine derivative, which are all known to strongly bind CuII. The radiopharmacological characterization of the two isomeric bispidine complexes includes quantitative labeling with 64CuII at ambient …

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