José S. Magalhães

Extracellular mitochondria: a potential player involved in exercise health benefits

Mafalda Barbosa Pedrosa, Lúcio Lara Santos, Rita Ferreira, José S. Magalhães

Exercise is widely recognized as an effective nonpharmacological therapy for noncommunicable diseases, with its health benefits mediated in part by exerkines. Recently, extracellular mitochondria (ex-Mito) have been suggested as a player in mediating intercellular communication. While it is known that the health …

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Assessing the Impact of Old Age on Upper Tract Urothelial Carcinoma: A Retrospective Analysis from a Portuguese Tertiary Center

F. Portugal Gaspar, Filipe Lopes, Jorge Correia, João Carvalho et autres

Introduction: Upper tract urothelial carcinoma is an infrequent but aggressive disease. Radical nephroureterectomy is the standard of care for nonmetastatic tumors. The potential implications of old age in the management of upper tract urothelial carcinoma are still controversial. Our aim was to …

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Data from Three Epigenetic Biomarkers, GDF15, TMEFF2, and VIM, Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

Vera L. Costa, Rui Henrique, Stine A. Danielsen, Sara Duarte-Pereira et autres

Abstract Purpose: To identify a panel of epigenetic biomarkers for accurate bladder cancer (BlCa) detection in urine sediments. Experimental Design: Gene expression microarray analysis of BlCa cell lines treated with 5-aza-2′-deoxycytidine and trichostatin A as well as 26 tissue samples was used …

Data from Three Epigenetic Biomarkers, GDF15, TMEFF2, and VIM, Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

Vera L. Costa, Rui Henrique, Stine A. Danielsen, Sara Duarte-Pereira et autres

Abstract Purpose: To identify a panel of epigenetic biomarkers for accurate bladder cancer (BlCa) detection in urine sediments. Experimental Design: Gene expression microarray analysis of BlCa cell lines treated with 5-aza-2′-deoxycytidine and trichostatin A as well as 26 tissue samples was used …

Supplementary Data from Three Epigenetic Biomarkers, GDF15, TMEFF2, and VIM, Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

Vera L. Costa, Rui Henrique, Stine A. Danielsen, Sara Duarte-Pereira et autres

Supplementary Figures S1-S4 and Supplementary Tables S1-S7.

Supplementary Data from Three Epigenetic Biomarkers, GDF15, TMEFF2, and VIM, Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

Vera L. Costa, Rui Henrique, Stine A. Danielsen, Sara Duarte-Pereira et autres

Supplementary Figures S1-S4 and Supplementary Tables S1-S7.

Does the placement of a collagen-fibrin sealant reduce complications of radical inguinal lymph node dissection? - Comparative study in patients with penile cancer

Andreia Bilé Silva, João Nuno Pereira, Rui Freitas, Isaac Braga et autres

OBJECTIVE: Management of patients with penile cancer (PeC) with palpable inguinal lymph nodes (ILNs) relies on radical ILN dissection (RILND). Low burden of nodal metastatic disease may lead to long-lasting survival with surgical management. Nevertheless, RILND involves significant postoperative morbidity. We compared …

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Histologic variants of urothelial carcinoma: does it change the survival outcomes in patients with bladder cancer managed with radical cystectomy?

J.N. Dos Santos Reis Pereira, J Reis, Ianna Lacerda Sampaio Braga, A.R. Freitas et autres

Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder

Susana Junqueira-Neto, Filipa Quintela Vieira, Diana Montezuma, Natália R. Costa et autres

Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared …

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Three Epigenetic Biomarkers, GDF15 , TMEFF2 , and VIM , Accurately Predict Bladder Cancer from DNA-Based Analyses of Urine Samples

Vera L. Costa, Rui Henrique, Stine A. Danielsen, Sara Duarte-Pereira et autres

PURPOSE: To identify a panel of epigenetic biomarkers for accurate bladder cancer (BlCa) detection in urine sediments. EXPERIMENTAL DESIGN: Gene expression microarray analysis of BlCa cell lines treated with 5-aza-2'-deoxycytidine and trichostatin A as well as 26 tissue samples was used to …

no, pt (code pays fourni par la source)