Stéphanie Woerner

INHALE-1: A Multicenter Randomized Trial of Inhaled Technosphere Insulin in Children With Type 1 Diabetes

Michael J. Haller, Lauren Kanapka, Roshanak Monzavi, Thomas J. Mouse et autres

OBJECTIVE: To evaluate inhaled technosphere insulin (TI) in children with diabetes. RESEARCH DESIGN AND METHODS: A total of 230 youth 4-17 years old with type 1 (98%) or type 2 (2%) diabetes treated with multiple daily injections of insulin were randomly assigned …

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A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes

Christine Bender, Alice Wiedeman, Alex Hu, Alyssa Ylescupidez et autres

CD4 + CD25 hi CD127 lo/− FOXP3 + regulatory T cells (T regs ) play a key role in preventing autoimmunity. In autoimmune type 1 diabetes (T1D), adoptive transfer of autologous polyclonal T regs has been shown to be safe in adults …

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Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes

Emily K. Sims, Abhishek Kulkarni, Audrey Hull, Stéphanie Woerner et autres

In preclinical models, α-difluoromethylornithine (DFMO), an ornithine decarboxylase (ODC) inhibitor, delays the onset of type 1 diabetes (T1D) by reducing β cell stress. However, the mechanism of DFMO action and its human tolerability remain unclear. In this study, we show that mice …

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SAT107 Assessing Continuous Glucose Monitor Alarm Use By Families Of Children With Diabetes

Victoria S. Ochs, Stéphanie Woerner, Ala Üstyol, Linda A. DiMeglio

Abstract Disclosure: V.S. Ochs: None. S.E. Woerner: Employee; Self; Lilly USA, LLC. A. Ustyol: None. L.A. DiMeglio: Advisory Board Member; Self; Merck, Abata. Consulting Fee; Self; Vertex. Background: Continuous glucose monitors (CGM) offer customizable alarms which alert persons with diabetes and their …

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THU277 Deletion Or inhibition Of Ornithine Decarboxylase Protects Islet β-cell Health And Is Associated With Preserved Residual C-peptide In Persons With Recent Onset Type 1 Diabetes

Batoul Hammoud, Linda A. DiMeglio, Abishek Kulkarni, Audrey Hull et autres

Abstract Disclosure: B. Hammoud: None. L.A. DiMeglio: None. A. Kulkarni: None. A. Hull: None. S. Woerner: None. S. Cabrera: None. L.D. Mastrandrea: None. F. Ouyang: None. S.N. Perkins: None. C. Evans-Molina: None. T.L. Mastracci: None. S.A. Tersey: None. S. Sarkar: None. E. …

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Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes

Gregory P. Forlenza, Jennifer McVean, Roy W. Beck, Colleen Bauza et autres

Importance: In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death. Calcium channel blockers reduce these effects and may be beneficial to beta cell preservation in type 1 diabetes. Objective: To determine the …

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Effect of Tight Glycemic Control on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes

Jennifer McVean, Gregory P. Forlenza, Roy W. Beck, Ryan Bailey et autres

Importance: Near normalization of glucose levels instituted immediately after diagnosis of type 1 diabetes has been postulated to preserve pancreatic beta cell function by reducing glucotoxicity. Previous studies have been hampered by an inability to achieve tight glycemic goals. Objective: To determine …

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Inhibition of Polyamine Biosynthesis Preserves β Cell Function in Type 1 Diabetes

Emily K. Sims, Abhishek Kulkarni, Audrey Hull, Stéphanie Woerner et autres

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Long-term Continuous Glucose Monitor Use in Very Young Children With Type 1 Diabetes: One-Year Results From the SENCE Study

Michelle Van Name, Lauren Kanapka, Kellee M. Miller, Anastasia Albanese-O’Neill et autres

Objectives: Achieving optimal glycemic outcomes in young children with type 1 diabetes (T1D) is challenging. This study examined the durability of continuous glucose monitoring (CGM) coupled with a family behavioral intervention (FBI) to improve glycemia. Study Design: This one-year study included an …

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Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial

Julia Ware, Charlotte K. Boughton, Janet M. Allen, Malgorzata E. Wilinska et autres

Background Closed-loop insulin delivery systems have the potential to address suboptimal glucose control in children and adolescents with type 1 diabetes. We compared safety and efficacy of the Cambridge hybrid closed-loop algorithm with usual care over 6 months in this population. Methods …

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Pediatric Type 2 Diabetes Presentation During the COVID-19 Pandemic

Anna Neyman, Zeina M. Nabhan, Stéphanie Woerner, Tamara S. Hannon

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Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Stephen E. Gitelman, Brian N. Bundy, Ele Ferrannini, Noha Lim et autres

BACKGROUND: Type 1 diabetes results from autoimmune-mediated destruction of β cells. The tyrosine kinase inhibitor imatinib might affect relevant immunological and metabolic pathways, and preclinical studies show that it reverses and prevents diabetes. Our aim was to evaluate the safety and efficacy …

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