Jan Sklenicka

Pirelli Abnormal Returns and Formula 1 Tyre Performance

Jan Sklenicka

This thesis investigates whether abnormal tyre performance during Formula 1 races translates into measurable reactions in Pirelli's stock returns. Using lap- by-lap telemetry data from 170 races over the 2018-2025 seasons, we construct a Tyre Performance Index (TPI) that captures abnormal tyre …

Inhibiting Amikacin Resistance in Multidrug-Resistant Bacteria with Cadmium and Pyrithione

Angel J. Magaña, David Chek Ling Ngo, Kenneth Burgos, Carolina Dominguez Maldonado et autres

Abstract The ongoing antibiotic resistance crisis is one of the most pressing public health challenges. Multidrug-resistant bacterial pathogens are reaching the point where some are becoming untreatable. Consequently, besides discovering novel antibiotics, alternative strategies must be explored to manage the problem. One …

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P-1346. Identification of aminoglycoside 6′-N-acetyltransferase type Ib small molecule inhibitors using mixture-based combinatorial libraries and structure-activity relationship studies

Jan Sklenicka, Tung Tran, Angel J. Magaña, María Soledad Ramirez et autres

Abstract Background The aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6’)-Ib] confers resistance to amikacin and other relevant aminoglycosides in Gram-negatives. To identify small molecule inhibitors of AAC(6’)-Ib that would overcome resistance, we utilized a strategy incorporating mixture-based combinatorial libraries, scaffold ranking, and positional scanning, …

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Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib-Mediated Amikacin Resistance in Multidrug- and Carbapenem-Resistant Clinical Strains by Cadmium in Combination with Pyrithione

Angel J. Magaña, David Chek Ling Ngo, Kenneth Burgos, Carolina Dominguez Maldonado et autres

The ongoing antibiotic resistance crisis is among the most pressing public health chal-lenges. The rise and dissemination of multidrug-resistant bacterial pathogens is reaching the point when some become untreatable. Consequently, besides discovering novel antibiotics, alternative strategies must be explored to manage the …

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Structure–Activity Relationship of Pyrrolidine Pentamine Derivatives as Inhibitors of the Aminoglycoside 6′-N-Acetyltransferase Type Ib

Jan Sklenicka, Tung Tran, María Soledad Ramirez, Haley M. Donow et autres

Resistance to amikacin and other major aminoglycosides is commonly due to enzymatic acetylation by the aminoglycoside 6′-N-acetyltransferase type I enzyme, of which type Ib [AAC(6′)-Ib] is the most widespread among Gram-negative pathogens. Finding enzymatic inhibitors could be an effective way to overcome …

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Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6′- N -acetyltransferase type Ib

Jan Sklenicka, Tung Tran, María Soledad Ramirez, Haley M. Donow et autres

Abstract Resistance to amikacin and other major aminoglycosides is commonly due to enzymatic acetylation by aminoglycoside 6′- N -acetyltransferase type I enzyme, of which type Ib [AAC(6′)-Ib] is the most widespread among Gram-negative pathogens. Finding enzymatic inhibitors could be an effective way …

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Predicting the outcomes of tennis matches. How important is the factor of different surfaces?

Jan Sklenicka

This thesis focuses on predicting the outcomes of ATP tennis matches with the aim of investigating the effect of different tennis surfaces. We define nine surface variables based on two different clustering methods, and incorporate these variables into models that were estimated …

Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions

David Chek Ling Ngo, Angel J. Magaña, Tung Tran, Jan Sklenicka et autres

Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at the 6′ position. These substitutions produced a …

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Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions

David Chek Ling Ngo, Angel J. Magaña, Tung Thanh Tran, Jan Sklenicka et autres

Plazomicin is a recently U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at the 6′ position. These substitutions produced a …

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Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation

Angel J. Magaña, Jan Sklenicka, Clemencia Pinilla, Marc A. Giulianotti et autres

Growing resistance to antimicrobial medicines is a critical health problem that must be urgently addressed. Adding to the increasing number of patients that succumb to infections, there are other consequences to the rise in resistance like the compromise of several medical procedures …

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