Anna Hoerder‐Suabedissen

Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

Elise Meijer, Marissa Mueller, Lukas B. Krone, Tomoko Yamagata et autres

One of the most distinctive features of the mammalian cerebral cortex is its laminar structure. Of all cortical layers, layer 6b (L6b) is by far the least studied, despite exhibiting direct sensitivity to orexin and having widespread connectivity, suggesting an important role …

gb, it, ch (code pays fourni par la source)

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima et autres

Subplate neurons (SpNs) are among the earliest-born and maturing neurons in the developing cerebral cortex. They arise from multiple origins and can be classified into several subgroups based on morphology, connectivity, and gene expression. These neurons play essential roles in cortical circuit …

jp, gb (code pays fourni par la source)

Deletion of Snap25 disrupts glial remodeling in aging mouse brain

Augustė Vadišiūtė, Florina Szabo, Sofia Luchanskaya, Vanessa Drevenakova et autres

motor neurons were unchanged. Age amplified astrocyte heterogeneity and microglial reactivity under synaptic silencing. These findings suggest that circuit topology shapes the spatial and cellular specificity of glial responses to chronic loss of synaptic activity.

gb, us (code pays fourni par la source)

Neuroserpin: A Potential Neuroprotective Agent in Mild Neonatal Hypoxic–Ischaemic Encephalopathy

Eri Kawashita, Yumi Fukuzaki, Jan A. Fischer, Lei Shi et autres

Neonatal hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment. This study investigates the cortical expression pattern of neuroserpin during postnatal brain development and evaluates its neuroprotective potential in …

jp, gb, us, cn (code pays fourni par la source)

Contrasting effects of global and local cortical activity on the regulation of sleep

Lukas B. Krone, J. Hamilton, Anna Hoerder‐Suabedissen, Clara Regine Valentina Marnitz et autres

Abstract The cortex is now recognised as a key regulator of sleep. It remains unclear, however, how sleep is affected by changes in cortical activity over different spatial scales. For instance, sleep states are associated with ‘global’ changes in activity across cortex, …

ch, gb (code pays fourni par la source)

The KAP1 chromatin regulator and Paupar long non-coding RNA control subventricular zone neural stem cell maintenance and neurogenesis

Farah Alammari, Jemima Becker, Bin Sun, Anna Hoerder‐Suabedissen et autres

Neural stem cells (NSCs) in the subventricular zone (SVZ) produce neurons throughout life. However, the epigenetic mechanisms that maintain NSCs and control neurogenesis remain unclear. We previously showed the long non-coding RNA (lncRNA) Paupar and KAP1 transcription co-factor control neuroblastoma cell growth. …

sa, gb (code pays fourni par la source)

Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

Elise Meijer, Marissa Mueller, Lukas B. Krone, Tomoko Yamagata et autres

One of the most distinctive features of the mammalian cerebral cortex is its laminar structure. Of all cortical layers, layer 6b (L6b) is by far the least studied, despite exhibiting direct sensitivity to orexin and having widespread connectivity, suggesting an important role …

gb, it, ch, jp (code pays fourni par la source)

Author response: Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

Elise Meijer, Marissa Mueller, Lukas B. Krone, Tomoko Yamagata et autres

One of the most distinctive features of the mammalian cerebral cortex is its laminar structure. Of all cortical layers, layer 6b (L6b) is by far the least-studied, despite exhibiting direct sensitivity to orexin and having widespread connectivity, suggesting an important role in …

Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

Elise Meijer, Marissa Mueller, Lukas B. Krone, Tomoko Yamagata et autres

Abstract One of the most distinctive features of the mammalian cerebral cortex is its laminar structure. Of all cortical layers, layer 6b (L6b) is by far the least-studied, despite exhibiting direct sensitivity to orexin and having widespread connectivity, suggesting an important role …

gb, it, ch, jp (code pays fourni par la source)

Neuroserpin: A Potential Neuroprotective Agent in Mild Neonatal Hypoxic-Ischaemic Encephalopathy

Eri Kawashita, Yumi Fukuzaki, Jan A. Fischer, Lei Shi et autres

Neonatal hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment. This study investigates the cortical expression pattern of neuroserpin during postnatal brain development and evaluates its neuroprotective potential in …

jp, gb, us, cn, hk (code pays fourni par la source)

Vigilance state dissociation induced by 5-MeO DMT in mice

Benjamin J. B. Bréant, José Prius-Mengual, A. J. Andrews, Anna Hoerder‐Suabedissen et autres

gb, es (code pays fourni par la source)

Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven cortical activation

Fernando Messore, Augustė Vadišiūtė, Hayley Edmead, Mohammed Abuelem et autres

In the somatosensory cortex of transgenic mice, Cre-recombinase is expressed under the control of the dopamine receptor D1 (Drd1a) promoter in lower layer 6. These neurons selectively project to the higher-order thalamic nuclei and participate in the cortico-thalamo-cortical loops involved in sensory …

gb, us, fr, ca (code pays fourni par la source)