Holly Symonds

Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors

Michelle Ghert, Patricia Schneider, Victoria Giglio, Andrew Duong et autres

IMPORTANCE: The use of perioperative, prophylactic, intravenous antibiotics is standard practice to reduce the risk of surgical site infection after oncologic resection and complex endoprosthetic reconstruction for lower extremity bone tumors. However, evidence guiding the duration of prophylactic treatment remains limited. OBJECTIVE: …

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Tissue-specific inactivation of p53 tumor suppression in the mouse.

Liya Gu, Holly Symonds, Terry Van Dyke, Tammy Bowman et autres

The p53 gene is the most frequent target of structural and functional genetic mutations in human cancer. Thus, considerable effort has been devoted to mapping the functional domains of p53 with regard to their impact on tumorigenesis in vivo. Studies have shown …

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Tissue-specific inactivation of p53 tumor suppression in the mouse.

Tammy Bowman, Holly Symonds, Liqiang Gu, Chun Yin et autres

The p53 gene is the most frequent target of structural and functional genetic mutations in human cancer. Thus, considerable effort has been devoted to mapping the functional domains of p53 with regard to their impact on tumorigenesis in vivo. Studies have shown …

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p53-Dependent apoptosis suppresses tumor growth and progression in vivo

Holly Symonds, Leonard Krall, Lee Ann Remington, Mayte Saenz-Robles et autres

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Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53.

Susan A. McCarthy, Holly Symonds, Terry Van Dyke

Several proteins encoded by DNA tumor viruses are thought to disrupt cellular growth control by interacting with key cellular proteins, such as p53 and pRB, that normally function to regulate cell growth. However, the biological consequences of intracellular complexing between the viral …

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Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.

Maria Teresa Sáenz Robles, Holly Symonds, J Chen, Terry Van Dyke

The ability of simian virus 40-encoded large T antigen to disrupt the growth control of a variety of cell types is related to its ability to interfere with certain cellular proteins, such as p53 and the retinoblastoma susceptibility gene product (pRB). We …

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Induction Versus Progression of Brain Tumor Development: Differential Functions for the pRB- and p53-Targeting Domains of Simian Virus 40 T Antigen

Maria Teresa Sáenz Robles, Holly Symonds, Jiazhou Chen, Terry Van Dyke

The ability of simian virus 40-encoded large T antigen to disrupt the growth control of a variety of cell types is related to its ability to interfere with certain cellular proteins, such as p53 and the retinoblastoma susceptibility gene product (pRB). We …

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p53-Dependent Apoptosis In Vivo: Impact of p53 Inactivation on Tumorigenesis

Holly Symonds, Leonard Krall, Lee Ann Remington, Maitane Robles et autres

Loss of tumor suppressor function clearly contributes to the multistep process of tumorigenesis, as evidenced by the frequent mutation of these genes in human cancer (Marshall 1991; Hinds and Weinberg 1994). Investigation into the mechanisms by which inactivation of tumor suppressors contributes …

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Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant.

Holly Symonds, Susan A. McCarthy, J Chen, James M. Pipas et autres

We have used the multifunctional transforming protein, simian virus 40 T antigen, as a probe to study the mechanisms of cell growth regulation in the intact organism. T antigen appears to perturb cell growth, at least in part, by stably interacting with …

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Use of Transgenic Mice Reveals Cell-Specific Transformation by a Simian Virus 40 T-Antigen Amino-Terminal Mutant

Holly Symonds, Susan A. McCarthy, Jiandong Chen, James M. Pipas et autres

We have used the multifunctional transforming protein, simian virus 40 T antigen, as a probe to study the mechanisms of cell growth regulation in the intact organism. T antigen appears to perturb cell growth, at least in part, by stably interacting with …

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Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53

Holly Symonds, J D Chen, Terry Van Dyke

The simian B-lymphotropic papovavirus (LPV) encodes a large tumor antigen (T antigen) which is 45% identical to both the simian virus 40 (SV40) and the polyomavirus (PyV) large T antigens. In transgenic mice, the transforming properties of the LPV T antigen are …

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