E. Laura Sherman

Allosteric Regulation of Glutamate Dehydrogenase

Zoe A. Hoffpauir, E. Laura Sherman, Hong Q. Smith, Thomas J. Smith

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Dissecting the Antenna in Human Glutamate Dehydrogenase: Understanding Its Role in Subunit Communication and Allosteric Regulation

Zoe A. Hoffpauir, E. Laura Sherman, Thomas J. Smith

Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l-glutamate. While GDH is found in all living organisms, only that from animals is highly allosterically regulated by a wide array of metabolites. Because only animal GDH has …

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Evidence Supporting the 19 β-Strand Model for Tom40 from Cysteine Scanning and Protease Site Accessibility Studies

Sebastian W.K. Lackey, Rebecca D. Taylor, Nancy E. Go, Annie Wong et autres

Most proteins found in mitochondria are translated in the cytosol and enter the organelle via the TOM complex (translocase of the outer mitochondrial membrane). Tom40 is the pore forming component of the complex. Although the three-dimensional structure of Tom40 has not been …

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Whole genome single nucleotide polymorphism associations with feed intake and feed efficiency in beef cattle1

E. Laura Sherman, J. D. Nkrumah, S. S. Moore

Feed intake and efficiency are economically important traits because feed is the greatest variable cost in beef production. Feed efficiency can be measured as residual feed intake (RFI), which is the difference between actual DMI of an animal and the expected DMI …

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Polymorphisms in positional candidate genes on BTA14 and BTA26 affect carcass quality in beef cattle

Elisa Marques, J. D. Nkrumah, E. Laura Sherman, S. S. Moore

Several studies have reported the presence of carcass quality QTL on BTA14 and BTA26, with no specific genes being conclusively linked as their cause. The aim of this study was to identify polymorphisms in genes known to affect lipid metabolism in other …

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Molecular basis for residual feed intake in beef cattle1

S. S. Moore, Fidalis D. N. Mujibi, E. Laura Sherman

Feed provision is one of the greatest costs of beef production and, with the increasing costs of feed, will remain so for the foreseeable future. Improvement in efficiency has the potential to not only increase profits for cattle producers, but also to …

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Fine mapping quantitative trait loci for feed intake and feed efficiency in beef cattle1

E. Laura Sherman, J. D. Nkrumah, Chengdao Li, R. Bartusiak et autres

Feed intake and feed efficiency are economically important traits in beef cattle because feed is the greatest variable cost in production. Feed efficiency can be measured as feed conversion ratio (FCR, intake per unit gain) or residual feed intake (RFI, measured as …

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Identification of polymorphisms influencing feed intake and efficiency in beef cattle

E. Laura Sherman, J. D. Nkrumah, Brenda M. Murdoch, S. S. Moore

Feed efficiency is an economically important trait in beef cattle. Net feed efficiency, measured as residual feed intake (RFI), is the difference between actual feed intake and the predicted feed intake required for maintenance and gain of the animal. SNPs that show …

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Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle1

E. Laura Sherman, J. D. Nkrumah, Brenda M. Murdoch, CHANGHONG LI et autres

Genes that regulate metabolism and energy partitioning have the potential to influence economically important traits in farm animals, as do polymorphisms within these genes. In the current study, SNP in the bovine neuropeptide Y (NPY), growth hormone receptor (GHR), ghrelin (GHRL), uncoupling …

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Primary genome scan to identify putative quantitative trait loci for feedlot growth rate, feed intake, and feed efficiency of beef cattle1

J. D. Nkrumah, E. Laura Sherman, Chengdao Li, Elisa Marques et autres

Feed intake and feed efficiency of beef cattle are economically relevant traits. The study was conducted to identify QTL for feed intake and feed efficiency of beef cattle by using genotype information from 100 microsatellite markers and 355 SNP genotyped across 400 …

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Effect of Mutations in Tom40 on Stability of the Translocase of the Outer Mitochondrial Membrane (TOM) Complex, Assembly of Tom40, and Import of Mitochondrial Preproteins

E. Laura Sherman, Rebecca D. Taylor, Nancy E. Go, Frank E. Nargang

Mitochondrial preproteins synthesized in the cytosol are imported through the mitochondrial outer membrane by the translocase of the outer mitochondrial membrane (TOM) complex. Tom40 is the major component of the complex and is essential for cell viability. We generated 21 different mutations …

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A genome-wide scan for quantitative trait loci affecting ultrasound and carcass backfat thickness in beef cattle.

C. Li, J. D. Nkrumah, R. Bartusiak, Alex A. Fu et autres