Maria Kaparou

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Faye Cole-Sinclair et autres

Nodular Lymphocyte Predominant Hodgkin Lymphoma With Aberrant Immunophenotype or Variant Histopathology: Insights From Case Series of Three Patients

Gurvin Chander, Hansini Dassanayake, Maria Kaparou, Maria Zahid Ahmed et autres

BACKGROUND: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with variant histopathology or aberrant immunophenotype is exceedingly rare and there is paucity of data with regards to its clinical characteristics and course. CASE REPORT: Herein, we present three cases of NLPHL with aberrant immunophenotype …

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Management of Allogeneic Stem Cell Transplantation for High-Risk AML following SARS-CoV-2 Associated Pancytopenia with Marked Bone Marrow Biopsy Alterations

Maria Kaparou, Zbigniew Rudzki, Hannah Victoria Giles, Vidhya Murthy et autres

The present study describes a patient aged 70 with very high-risk AML who successfully received a nonmyeloablative matched unrelated donor allograft shortly following SARS-CoV-2 infection, which manifested with mild cough, interstitial abnormalities on chest CT, and pancytopenia with profound bone marrow biopsy …

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COVID‐19 in bone marrow transplant recipients: reflecting on a single centre experience

Alexandros Kanellopoulos, Maria Zahid Ahmed, Bhuvan Kishore, Richard Lovell et autres

Coronavirus disease 2019 (COVID-19) is caused by the novel SARS-CoV-2 virus and has been declared a pandemic on the 9th of March by the WHO. A hallmark of COVID-19 management is supportive care and there is still no convincing evidence for a …

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First case of near haploid philadelphia negative B-Cell acute lymphoblastic leukaemia relapsing as acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation

Claire Horgan, Charalampos Kartsios, Emmanouil Nikolousis, Shankara Paneesha et autres

Herein we present a female patient aged 61 with Philadelphia negative acute lymphoblastic leukaemia demonstrating near haploid karyotype and abnormal TP53 expression at diagnosis, who relapsed with lineage switch as Acute Monocytic Leukemia post allogeneic stem cell transplantation. Molecular analysis established that …

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Autoimmune Cytopenias Developing Late Post Alemtuzumab-Based Allogeneic Stem Cell Transplantation: Presentation of Short Case Series from a Transplant Center

Rebecca Lloyd, Emmanouil Nikolousis, Bhuvan Kishore, Richard Lovell et autres

Stem cell transplantation remains the curative option for many patients with hematological malignancies. The long-term effects of these treatments on the patients and their immune systems have been extensively investigated, but there remains a paucity of data regarding autoimmune manifestations post-transplant, although …

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Mixed T-cell chimerism at 3 months followed by donor lymphocyte infusion is independently associated with favorable outcomes in alemtuzumab-based reduced-intensity allogeneic hematopoietic stem cell transplantation

Graham McIlroy, Emmanouil Nikolousis, Nervana Abou‐Zeid, Shankara Paneesha et autres

Reduced intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT) has transformed the management of older or infirm patients suffering from hematological malignanc...

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Reduced intensity alemtuzumab-containing allogeneic stem cell transplantation for relapsed/refractory low grade lymphoma: reflections on a single center experience

Claire Horgan, Shereef Elmoamly, Graham McIlroy, David James Davies et autres

Despite improvements in overall survival in patients with low grade lymphoma over the past 20 years [1,2], allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative opti...

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Azacitidine Improves Outcome in Patients with MDS and AML with High Risk Cytogenetics - a Single Center Experience

Vidhya Murthy, Nilupulee Kapuge, Charalampos Kartsios, Joanne C Ewing et autres

Abstract Azacitidine is a novel hypomethylating agent shown to improve leukaemia free survival and overall survival in comparison with other modalities of treatment in MDS and AML patients. There is proven reduction in transfusion requirements by improvement in haematological parameters with continuous …

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Graft-versus-leukaemia effect post fludarabine, melphalan and alemtuzumab reduced intensity allogeneic stem cell transplant in HIV-infected patient with acute myeloid leukaemia

Alexandros Kanellopoulos, Maria Kaparou, Evgenia Xenou, Shankara Paneesha et autres

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Reduced‐intensity conditioning allogeneic transplantation after salvage treatment with DT ‐ PACE in myeloma patients relapsing early after autologous transplant

Kate Randall, Maria Kaparou, Evgenia Xenou, Shankara Paneesha et autres

OBJECTIVE: In this retrospective single-centre study, we have looked into the transplant outcomes(overall survival OS, progression-free survival PFS, GvHD) and the role of chimerism, DLI and pretransplant characteristics in patients who had a suboptimal response (<12 months) to an autologous stem cell …

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Multiple cutaneous reticulohistiocytosis with T‐cell large granular lymphocyte clonopathy

Pavlos Papadantonakis, Maria Kaparou, Helen Α. Papadaki, Leonidas Marinos et autres

Abstract A 63‐year‐old Caucasian man presented with a 4‐month history of disseminated asymptomatic reddish‐brown papulonodular lesions. A skin biopsy showed dermal infiltration with CD68+ histiocytes, predominantly with eosinophilic cytoplasm, some with a ground‐glass cytoplasm, and a small number of giant cells. The …

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