Inmaculada Ibañez de Cáceres

A Novel Exon 19 EGFR mutation in a patient with lung adenocarcinoma: A Case Report and Literature Review

Laura Gutiérrez-Sainz, Rocío Rosas-Alonso, Carlos Rodríguez‐Antolín, Carmen Rodríguez‐Jiménez et autres

Non-small-cell lung cancer (NSCLC) exemplifies how biomarker-driven therapies can alter the natural course of a disease. Clinically significant mutations in the epidermal growth factor receptor (EGFR) in NSCLC include a spectrum of substitutions, deletions, and insertions, mainly affecting exons 18 to 21. …

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Unveiling miR-451a and miR-142-3p as Prognostic Markers in NSCLC via sEV Liquid Biopsy

Miranda Burdiel Herencia, Julia Jiménez, Rafael Meneguz Moreno, Carlos Rodríguez‐Antolín et autres

ABSTRACT Despite advancements in personalized cancer therapies, platinum-based chemotherapy remains the cornerstone for treating solid tumors, including Non-Small Cell Lung Cancer (NSCLC). The integration of novel immunotherapies with platinum compounds has shown promising outcomes for the treatment of advanced disease. However, a …

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EP.12C.04 Location of Metastases and Prognosis of Patients with Metastatic KRAS-Mutant Non-Small Cell Lung Cancer

L. Gutiérrez Sainz, I. Ozáez, Oliver Higuera Gómez, Julia Villamayor et autres

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The small MAF transcription factor MAFG co-opts MITF to promote melanoma progression

Olga Vera, Michael Martinez, Zulaida Soto-Vargas, Kaizhen Wang et autres

ABSTRACT Transcription factor deregulation potently drives melanoma progression by dynamically and reversibly controlling gene expression programs. We previously identified the small MAF family transcription factor MAFG as a putative driver of melanoma progression, prompting an in-depth evaluation of its role in melanoma. …

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Evaluation of the clinical use of MGMT methylation in extracellular vesicle-based liquid biopsy as a tool for glioblastoma patient management

Rocío Rosas-Alonso, Julian Colmenarejo-Fernández, Olga Pernía, Miranda Burdiel et autres

Glioblastoma (GB) is a devastating tumor of the central nervous system characterized by a poor prognosis. One of the best-established predictive biomarker in IDH-wildtype GB is O6-methylguanine-DNA methyltransferase (MGMT) methylation (mMGMT), which is associated with improved treatment response and survival. However, current …

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Prognostic Potential of Candidate miRNAs in Lung Cancer: Insights from Tissue and Liquid Biopsies

Abelardo Meneses García, Olga Vera, Darío Sánchez-Cabrero, Laura Gutiérrez et autres

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Glioma Patient Management: Utilizing MGMT Methylation in Extracellular Vesicle-Based Liquid Biopsy

Inmaculada Ibañez de Cáceres, Rocío Rosas-Alonso, Olga Pernía, Miranda Burdiel et autres

EP11.03-05 Molecular Characterization and Prognosis of Patients with KRAS Mutant Non-small Cell Lung Cancer

L. Gutiérrez Sainz, Julia Villamayor, O. Higuera, Patricia Cruz Castellanos et autres

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MiR-151a: a robust endogenous control for normalizing small extracellular vesicle cargo in human cancer

Miranda Burdiel, Julia Jiménez, Carlos Rodríguez‐Antolín, Álvaro García-Guede et autres

Small extracellular vesicles (sEVs) in the blood of cancer patients contain higher amounts of tumor markers than those identified as free-circulating. miRNAs have significant biomedical relevance due to their high stability and feasible detection. However, there is no reliable endogenous control available …

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miR-124 as a Liquid Biopsy Prognostic Biomarker in Small Extracellular Vesicles from NSCLC Patients

Darío Sánchez-Cabrero, Álvaro García-Guede, Miranda Burdiel, Olga Pernía et autres

Despite advances in non-small cell lung cancer (NSCLC) research, this is still the most common cancer type that has been diagnosed up to date. microRNAs have emerged as useful clinical biomarkers in both tissue and liquid biopsy. However, there are no reliable …

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Prognostic Impact of Dihydropyrimidine Dehydrogenase Germline Variants in Unresectable Non-Small Cell Lung Cancer Patients Treated with Platin-Based Chemotherapy

Javier Guijarro-Eguinoa, Sara Arjona-Hernandez, Stefan Mark Stewart, Olga Pernía et autres

Platin-based chemotherapy is the standard treatment for patients with non-small cell lung cancer (NSCLC). However, resistance to this therapy is a major obstacle in successful treatment. In this study, we aimed to investigate the impact of several pharmacogenetic variants in patients with …

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Identification of miR-151a as a novel endogenous control for small extracellular vesicle cargo normalization in human cancer

Miranda Burdiel, Julia Jiménez, Carlos Rodríguez‐Antolín, Álvaro García-Guede et autres

Abstract Background: Small extracellular vesicles (sEVs) in the blood of cancer patients contain higher amounts of tumor markers than those identified as free-circulating. miRNAs have significant biomedical relevance due to their high stability and feasible detection. However, there is no reliable endogenous …

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