Isaac Manyonda

Menopausal hormone therapy for breast cancer patients: what is the current evidence?

Sarah Glynne, James A. Simon, Stephen John Payne, Louise R. Newson et autres

IMPORTANCE AND OBJECTIVES: Many breast cancer survivors struggle with menopausal symptoms due to oncological treatment-induced hormone deficiency, or because they experience menopause some years after completing treatment, but have limited menopause treatment options. Estrogen replacement therapy is the most effective treatment for …

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Safety of e‐cigarettes and nicotine patches as stop‐smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E‐cigarettes and Patches (PREP) randomized controlled trial

Francesca Pesola, Katie Myers Smith, Anna Phillips‐Waller, Dunja Przulj et autres

AIMS: The aim of this study was to examine the safety of e-cigarettes (EC) and nicotine patches (NRT) when used to help pregnant smokers quit. DESIGN: A recent trial of EC versus NRT reported safety outcomes in the randomized arms. We conducted …

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Effect of myo-inositol and di-chiro inositol plus vitamin D supplementation during pregnancy on prevention of gestational diabetes: a multi-centric, prospective, randomized, double-blind clinical trial

Hema Divakar, Sheetal Bhimprasad Joshi, Vidya A. Thobbi, Shobha Bembalgi et autres

Background: Aim of study was to evaluate the impact of myoinositol and D-chiro inositol plus vitamin D supplementation on the prevention of gestational diabetes mellitus (GDM) in pregnant women. Methods: In the multi-centric, prospective, randomised, double-blind clinical trial, either vitamin D alone …

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Helping pregnant smokers quit: a multi-centre randomised controlled trial of electronic cigarettes versus nicotine replacement therapy

Dunja Przulj, Francesca Pesola, Katie Myers Smith, Hayden J. McRobbie et autres

Background: Some pregnant smokers try e-cigarettes, but effectiveness and safety of such use are unknown. Objectives: To compare effectiveness and safety of nicotine patches and e-cigarettes in pregnancy. Design: A pragmatic multi-centre randomised controlled trial. Setting: Twenty-three hospitals across England, and a …

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Effects on heavy menstrual bleeding and pregnancy of uterine artery embolization ( UAE ) or myomectomy for women with uterine fibroids wishing to avoid hysterectomy: The FEMME randomized controlled trial

Füsun Sirkeci, John Moss, Anna Maria Belli, Klim McPherson et autres

OBJECTIVE: To determine treatment options (myomectomy vs. uterine artery embolization (UAE)) for women wishing to avoid hysterectomy. METHODS: A multicenter randomized controlled trial was conducted on 254 women and data were collected on fibroid-specific quality of life (UFS-QOL), loss of menstrual blood, …

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Author Correction: Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial

Peter Hájek, Dunja Przulj, Francesca Pesola, Chris Griffiths et autres

In the version of this article initially published, there was an incorrect statistic in the “Secondary outcomes” section of the Results: “63 of 171” should have read “63 of 571.” In the “Study arms” section of the Methods, “18%” should have read …

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Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial

Peter Hájek, Dunja Przulj, Francesca Pesola, Chris Griffiths et autres

Nicotine replacement therapy, in the form of nicotine patches, is commonly offered to pregnant women who smoke to help them to stop smoking, but this approach has limited efficacy in this population. Electronic cigarettes (e-cigarettes) are also used by pregnant women who …

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The surgical menopause

Ouma Pillay, Isaac Manyonda

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Randomised Controlled Trial of Particles Used in Uterine fibRoid Embolisation (PURE): Non-Spherical Polyvinyl Alcohol Versus Calibrated Microspheres

Raj Kumar Das, Anita Wale, Seyed Ameli Renani, Lakshmi Ratnam et autres

PURPOSE: The PURE study is a randomised controlled trial (RCT) comparing the clinical and MRI outcomes of patients treated with non-spherical polyvinyl alcohol, ns-PVA (Contour PVA-Boston Scientific-355-500 & 500-700 microns) versus calibrated hydrogel microspheres (Embozene-Varian Inc-700 & 900 microns) for symptomatic uterine …

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Could Perimenopausal Estrogen Prevent Breast Cancer? Exploring the Differential Effects of Estrogen-Only Versus Combined Hormone Replacement Therapy

Isaac Manyonda, Vikram Sinai Talaulikar, Roxanna Pirhadi, John Headley Ward et autres

Breast cancer is the commonest cancer among women in the western world, accounting for up to 30% of all cancers in women. There is a long-standing controversy about the potential link to hormone replacement therapy (HRT), with large observational studies suggesting that …

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Uterine artery embolization or myomectomy for women with uterine fibroids: Four-year follow-up of a randomised controlled trial

JANE P. DANIELS, Lee Middleton, Versha Cheed, WILLIAM M. P. McKINNON et autres

OBJECTIVE: To examine the quality of life experienced by women with symptomatic uterine fibroids who had been treated with UAE in comparison to myomectomy. We report the four-year follow-up of the FEMME randomised trial. Two-year follow-up data has been previously reported. STUDY …

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Uterine artery embolisation or myomectomy for women with uterine fibroids wishing to avoid hysterectomy: a cost–utility analysis of the FEMME trial

Dikshyanta Rana, Olivia Y. Wu, Versha Cheed, Lee Middleton et autres

OBJECTIVES: To assess the cost-effectiveness of uterine artery embolisation (UAE) and myomectomy for women with symptomatic uterine fibroids wishing to avoid hysterectomy. DESIGN: Economic evaluation alongside the FEMME randomised controlled trial. SETTING: 29 UK hospitals. POPULATION: Premenopausal women who had symptomatic uterine …

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