Liping Sun

Natural medicines for asthma management: mechanisms aligned with endotypes and multi-dimensional intervention

Jiaxiang Sun, Hui Wang, Xue Li, Ping Wang et autres

Background: Asthma is a heterogeneous chronic inflammatory airway disease affecting over 300 million people globally. Inhaled corticosteroids remain first-line therapy but cause adverse effects and fail to address core pathologies in 5%-10% of patients-particularly those with Type 2-low endotypes exhibiting glucocorticoid resistance. …

cn (code pays fourni par la source)

Machine learning-based ultrasound radiomics for prediction of 6-month local thermal ablation response in benign thyroid nodules: a multicenter study

MD Xiaowan Bo, Zhuoran Wang, Chongke Zhao, Chaonan Li et autres

Objective: This study aimed to develop a machine learning (ML)-based ultrasound (US) radiomics model for prediction of 6-month local treatment response (LTR) ofthermal ablation (TA) for benign thyroid nodules (BTNs). Methods: Between January 2018 and July 2021, a total of 388 patients …

cn, us (code pays fourni par la source)

Mechanistic study on comorbidities of kidney stones and sepsis using transcriptome sequencing combined with single-cell spatial transcriptome sequencing

Liping Sun, R Li, Ke Zhang, Wenzhi Gao

Kidney stones and sepsis have a complex pathological association. Urinary obstruction and infection caused by kidney stones can easily induce sepsis, leading to increased mortality and poor prognosis. However, the molecular mechanism underlying their comorbidity remains unclear, and there is a lack …

cn (code pays fourni par la source)

Perioperative anesthetic management in pediatric patients with medically refractory pulmonary arterial hypertension undergoing surgical or transcatheter potts shunt: a retrospective case series

Liping Sun, Ning Ma, Xiafeng Yu, Lijun Fu et autres

BACKGROUND: Pulmonary arterial hypertension (PAH), a life-threatening disorder in children, necessitates palliative interventions like Potts shunt (surgical/transcatheter) for medically refractory cases. Perioperative anesthesia management remains challenging due to hemodynamic instability. This study describes our institutional anesthetic approach and summarizes the perioperative outcomes …

cn (code pays fourni par la source)

Zhi-Chuan-Ling alleviates OVA-induced allergic asthma by suppressing M2 macrophage polarization via the PI3K/AKT/mTOR/STAT6 pathway

Sihui Xing, Huidan Chen, Ling Wang, Siye Lv et autres

BACKGROUND: Allergic asthma, predominantly driven by Th2 immune responses, is a chronic respiratory disease that poses a significant threat to human health. Zhi-Chuan-Ling (ZCL), a traditional Chinese medicine widely used for the treatment of asthma and wheezy bronchitis, has been shown to …

cn (code pays fourni par la source)

A dual-core driven hybrid radiomics integrates multiple views of greyscale ultrasound image for the early management from diagnosis to biopsy suggestion of BI-RADS 4 breast lesions: a prospective multicenter study

Bo Zhou, Liping Sun, Han-Sheng Xia, Bin Tan et autres

OBJECTIVES: This study aimed to investigate the potential of ultrasound (US) radiomics approaches based on machine learning (ML) and deep learning (DL) in the early management from diagnosis to biopsy suggestion of Breast Imaging Reporting and Data System (BI-RADS) 4 breast lesions. …

cn, de (code pays fourni par la source)

Mendelian randomization analysis of the causal relationship between micronutrients and childhood asthma

Zhimei Liu, Caiwen Wang, Xiaofei Xie, Huidan Chen et autres

Background Existing research have suggested a significant association between micronutrients and childhood asthma, but the specific causal relationship between micronutrients and childhood asthma remains unclear. Therefore, we aimed to assess the causal relationship between micronutrients and childhood asthma using Mendelian randomization methods.Methods …

cn (code pays fourni par la source)

A novel drug that reduces pneumococcal toxicity by targeting pneumolysin (PLY): efficacy of the traditional Chinese medicine Radix Paeoniae Alba

Yan Xu, Jing Han, Yonglin Zhou, Liping Sun

Objective While existing virulence-targeting strategies predominantly rely on single-component inhibitors that exert evolutionary pressure, this study pioneers an innovative approach using the multicomponent traditional Chinese medicine Radix Paeoniae Alba (RPA). Unlike conventional monotherapeutic agents, RPA uniquely inhibits pneumolysin (PLY) oligomerization without affecting …

cn (code pays fourni par la source)

Zhichuanling oral liquid attenuates airway inflammation in asthma by targeting the STIM1/CHOP/JNK axis

Huidan Chen, Jiaqi Wu, Yue Li, Zhongtian Wang et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Zhichuanling oral liquid (ZCLOL) is a multi-component traditional Chinese medicine formulation that has been widely used in the clinical management of asthma. However, the molecular mechanisms underlying its clinical efficacy remain largely undefined, particularly regarding calcium homeostasis and endoplasmic reticulum …

cn (code pays fourni par la source)

Potential Targets and Mechanism of Action of Wangwei Powder in Tic Disorder Therapy: Bioinformatics and Network Pharmacology Analyses

Haijiao Lin, Yiquan Li, Liping Sun, Zhongtian Wang et autres

Introduction: Tic disorders are neuropsychiatric conditions characterized by involuntary motor or vocal tics; however, the mechanisms underlying these disorders and potential therapeutic targets remain unknown. Therefore, this study investigated the mechanisms underlying tic disorders, particularly focusing on the role of mitochondrial energy …

cn (code pays fourni par la source)

Kir4.1-mediated immunophenotypic OPCs underlies sevoflurane-induced hypomyelination in the developing brain

Liping Sun, Luping Feng, Yuxin Zhang, Mengqin Shan et autres

Clinical and animal experimental studies demonstrate that prolonged or repeated general anesthesia (GA) impairs myelination in the developing brain. However, the underlying cellular mechanisms remain unclear. Oligodendrocyte precursor cells (OPCs), as the primary source cells to myelination, have recently been shown to …

cn (code pays fourni par la source)

Nomograms Based on Myocardial Strain and Myocardial Work to Predict Low Cardiac Output Syndrome in Children Undergoing Surgery for Congenital Heart Disease

Xiaoxue Qin, Yingzhi Dan, Kan Zhang, Chaoyang Tong et autres

cn, es (code pays fourni par la source)