Berthe L.F. van Eck‐Smit

Lymphatic mapping for image-guided radiotherapy in patients with locally advanced uterine cervical cancer: a feasibility study

Judit A. Adam, Edwin Poel, Berthe L.F. van Eck‐Smit, Constantijne H. Mom et autres

Abstract Background Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC). No imaging method can successfully detect all (micro)metastases. This may result in (lymph node) recurrence after chemoradiation. We hypothesized that lymphatic mapping could identify nodes at …

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[18F]FDG-PET or PET/CT in the evaluation of pelvic and para-aortic lymph nodes in patients with locally advanced cervical cancer: A systematic review of the literature

Judit A. Adam, Pascal R. van Diepen, Constantijne H. Mom, Jaap Stoker et autres

Purpose Imaging is essential in detecting lymph node metastases for radiotherapy treatment planning in locally advanced cervical cancer (LACC). There are not many data on the performance of [ 18 F]FDG-PET(CT) in showing lymph node metastases in LACC. We pooled sensitivity and …

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Correction: Long-Term Changes of Subcutaneous Fat Mass in HIV-Infected Children on Antiretroviral Therapy: A Retrospective Analysis of Longitudinal Data from Two Pediatric HIV-Cohorts

Sophie Cohen, Steve Innes, Sibyl P. M. Geelen, Jonathan C. K. Wells et autres

[This corrects the article DOI: 10.1371/journal.pone.0120927.]

Novel molecular imaging ligands targeting matrix metalloproteinases 2 and 9 for imaging of unstable atherosclerotic plaques

Nazanin Hakimzadeh, Victorine A. Pinas, Ger T. Molenaar, Vivian de Waard et autres

Molecular imaging of matrix metalloproteinases (MMPs) may allow detection of atherosclerotic lesions vulnerable to rupture. In this study, we develop a novel radiolabelled compound that can target gelatinase MMP subtypes (MMP2/9) with high selectivity and inhibitory potency. Inhibitory potencies of several halogenated …

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FDG-PET/CT for differentiating between aseptic and septic delayed union in the lower extremity

Kirsten E. van Vliet, Vincent M. de Jong, M. F. Termaat, Tim Schepers et autres

18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) has proven to have a high diagnostic accuracy for the detection of bone infections. In patients with delayed union it may be clinically important to differentiate between aseptic and septic delayed union. The aim …

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Cardiac 123 I- m IBG scintigraphy is associated with freedom of appropriate ICD therapy in stable chronic heart failure patients

Derk O. Verschure, Joris R. de Groot, Siroos Mirzaei, Olivier Gheysens et autres

Aim Chronic heart failure (CHF) is a life-threatening clinical syndrome, partly due to sudden cardiac death (SCD). Implantable cardioverter defibrillators (ICD) for primary prevention of SCD have improved overall survival of CHF patients. However, a high percentage of patients never receives appropriate …

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Feasibility, toxicity and response of upfront metaiodobenzylguanidine therapy therapy followed by German Pediatric Oncology Group Neuroblastoma 2004 protocol in newly diagnosed stage 4 neuroblastoma patients

K. C. J. M. Kraal, G. M. Bleeker, Berthe L.F. van Eck‐Smit, Natasha K. A. van Eijkelenburg et autres

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A European myocardial 123I-mIBG cross-calibration phantom study

Derk O. Verschure, Edwin Poel, Kenichi Nakajima, Koichi Okuda et autres

Planar myocardial 123 I- meta -iodobenzylguanidine ( 123 I- m IBG) scintigraphy is a highly reproducible technique. However, differences in collimator use are one of the most important factors that cause variation among institutions and studies in heart-to-mediastinum (H/M) ratio. Therefore, standardization …

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Myocardial 123I-mIBG scintigraphy in relation to markers of inflammation and long-term clinical outcome in patients with stable chronic heart failure

Derk O. Verschure, René Lutter, Berthe L.F. van Eck‐Smit, G. Aernout Somsen et autres

Chronic heart failure (CHF) results in both increased cardiac sympathetic activity and myocardial inflammation. The aim of this study was to identify the relationship between severity of heart failure (i.e., NT-proBNP and LVEF), cardiac sympathetic activity (123I-mIBG scintigraphy), and measures of inflammation …

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Polymorphism of SLC6A2 gene does not influence outcome of myocardial 123I-mIBG scintigraphy in patients with chronic heart failure

Derk O. Verschure, Frank Baas, Berthe L.F. van Eck‐Smit, G. Aernout Somsen et autres

The NET, encoded by SLC6A2, is responsible for presynaptic NE-reuptake. 123I-mIBG is clinically used to evaluate cardiac sympathetic function. However, it is unknown if polymorphism of SLC6A2 influences cardiac sympathetic activity as assessed with 123I-mIBG. Therefore we studied the influence of SLC6A2 …

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Cardiac sympathetic activity in chronic heart failure: cardiac 123I-mIBG scintigraphy to improve patient selection for ICD implantation

Derk O. Verschure, Berthe L.F. van Eck‐Smit, G. Aernout Somsen, Remco J.J. Knol et autres

Heart failure is a life-threatening disease with a growing incidence in the Netherlands. This growing incidence is related to increased life expectancy, improvement of survival after myocardial infarction and better treatment options for heart failure. As a consequence, the costs related to …

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Cardiac sympathetic activity in 22q11.2 deletion syndrome

Derk O. Verschure, Erik Boot, Thérèse A. van Amelsvoort, Jan Booij et autres

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