AM Jones

567 Prevalence and predictors of hidden obesity and hidden fat free mass depletion in adults with cystic fibrosis at a large regional centre in the North West of England

Laura Kinsey, A. Horsley, AM Jones

P261 Presentation and recovery from pulmonary exacerbations in cystic fibrosis and comparison of those with and without CFTR modulators

H Siy-Yap, V. Musgrave, Evelyn Looi, L.E. Wadsworth et autres

Objectives Recent falls in CF admissions have been attributed to reduced exacerbations (PEx) in patients on CFTR modulators. We aimed to understand how these have affected the presentation and course of PEx. Methods Admission data were collected over 9m from July 2023 …

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WS13.04 Multimodal analysis of systemic inflammatory response to elexacaftor/tezacaftor/ivacaftor therapy

Robert W. Lord, Rouhollah Maher, Saad Aleem, Deanne J. Brice et autres

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S26 Untargeted sputum proteomics reveals anti-inflammatory effects of CFTR modulation

RE Maher, E Barrett, PJ Barry, Edward Emmott et autres

Background Global proteomics methodologies identifies disease pathways and protein biomarkers with translational potential by capturing the proteome, an entire set of proteins within biological samples. These techniques were applied to a cystic fibrosis (CF) cohort commencing the cystic fibrosis conductance regulator (CFTR) …

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P249 CF BOOST – engaging the disengaged

Heidi Green, Mary Clegg, F. Dowdall, V. Kendall et autres

Background In our large adult CF centre, we adhere to national guidelines on the management of cystic fibrosis (CF) but have noticed that even the best ‘standard CF care’ does not suit all patients. We have a cohort of patients that deteriorate …

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P108 Reclassification of aspergillosis phenotype in adult CF patients & 10 year follow up data

LJ Collier, RJ Bright-Thomas, David W. Denning, MD Richardson et autres

Introduction and objectives Patients from Manchester Adult Cystic Fibrosis Centre were classified for Aspergillus disease in CF (Baxter et al. 2013). These patients have been followed up for 10 years to monitor clinical outcomes and eligible patients have been re-phenotyped to investigate …

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S137 Understanding the mechanisms for the increased prevalence of gastro-oesophageal reflux in cystic fibrosis

RW Lord, John Casey, LA Houghton, Sam Treadway et autres

Objectives There is as yet no widely accepted explanation for the increased prevalence of gastro-oesophageal reflux seen in CF populations. It is believed that increased reflux may negatively affect CF lung disease, possibly as a consequence of reflux aspiration. However at present …

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P112 The use of quantitative proteomics to assess the impact of reflux aspiration on cystic fibrosis lung disease

RW Lord, RE Maher, Victoria M. Harman, Sam Treadway et autres

Background Reflux aspiration (RA) occurs when gastric fluid is introduced into the lower respiratory tract, and has the potential to injure the lung. However in a cohort of 41 adult CF patients, we were unable to demonstrate a relationship between oesophageal combined …

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AB1149 Cystic fibrosis and inflammatory arthritis requiring immunosuppression: a worrying combination?

Mokhles Ibrahim, Elizabeth A. Clarke, Katherine J. Martin, Daniel Gavin Peckham et autres

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S53 Outcomes following bronchial artery embolisation for haemoptysis in adults with cystic fibrosis

WG Flight, PJ Barry, RJ Bright-Thomas, Stephen A. Butterfield et autres

Introduction Bronchial artery embolisation (BAE) is recommended as the therapy of choice for massive haemoptysis in cystic fibrosis (CF) but there are no randomised controlled trials of BAE in this setting. Outcomes from BAE are uncertain and the efficacy of BAE in …

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Screening protocols to detect subclinical respiratory infections in PID: findings from a European survey

Stephen R.A. Jolles, Silvia Sánchez‐Ramón, Isabella Quinti, Pere Soler‐Palacín et autres

S102 The effect of respiratory viruses on the lung microbiome of adults with cystic fibrosis

WG Flight, JR Marchesi, Ann Smith, P. Norville et autres

Introduction Viral respiratory infection (VRI) has been implicated in the pathogenesis of cystic fibrosis (CF) lung disease and it has been hypothesised that respiratory viruses may predispose CF patients to acquisition of bacterial pathogens. We performed a prospective observational study to determine …

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