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Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
Supplementary figure legends, supplementary figure 1 and 2
Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
A heatmap generated using K-means clustering of expression of VEGF-A associated genes; LG-BSG samples (blue) in the disease type histology (upper legends) cluster with normal brain (purple). DIPG (red) clusters with GBM (green). DIPG (green), pHGG/GBM (red).
Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
Supplemental Figure 2: VEGF mRNA expression in DIPG in comparison to normal brain (n=31) as analyzed by R2 (R2.amc.nl), clustered by stage of disease; unknown (n=10), pretreatment (n=2) and postmortem (n=23)
Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
Supplementary figure legends, supplementary figure 1 and 2
Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
Supplemental Figure 2: VEGF mRNA expression in DIPG in comparison to normal brain (n=31) as analyzed by R2 (R2.amc.nl), clustered by stage of disease; unknown (n=10), pretreatment (n=2) and postmortem (n=23)
Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
A heatmap generated using K-means clustering of expression of VEGF-A associated genes; LG-BSG samples (blue) in the disease type histology (upper legends) cluster with normal brain (purple). DIPG (red) clusters with GBM (green). DIPG (green), pHGG/GBM (red).
Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
Abstract The role of the VEGF inhibitor bevacizumab in the treatment of diffuse intrinsic pontine glioma (DIPG) is unclear. We aim to study the biodistribution and uptake of zirconium-89 (89Zr)-labeled bevacizumab in DIPG mouse models. Human E98-FM, U251-FM glioma cells, and HSJD-DIPG-007-FLUC …
Marc H.A. Jansen, Tonny Lagerweij, Andreas Sewing, Daniëlle J. Vugts et autres
Abstract The role of the VEGF inhibitor bevacizumab in the treatment of diffuse intrinsic pontine glioma (DIPG) is unclear. We aim to study the biodistribution and uptake of zirconium-89 (89Zr)-labeled bevacizumab in DIPG mouse models. Human E98-FM, U251-FM glioma cells, and HSJD-DIPG-007-FLUC …
Michaël Hananja Meel, Mark C. de Gooijer, Dennis Serge Metselaar, Andreas Sewing et autres
Legends pertaining to supplementary figures and tables
Michaël Hananja Meel, Mark C. de Gooijer, Dennis Serge Metselaar, Andreas Sewing et autres
File containing all supplementary figures
Michaël Hananja Meel, Mark C. de Gooijer, Dennis Serge Metselaar, Andreas Sewing et autres
Sequences of shRNA constructs used in the present study.
Michaël Hananja Meel, Mark C. de Gooijer, Dennis Serge Metselaar, Andreas Sewing et autres
AbstractPurpose: Diffuse intrinsic pontine glioma (DIPG) is an incurable type of pediatric brain cancer, which in the majority of cases is driven by mutations in genes encoding histone 3 (H3K27M). We here determined the preclinical therapeutic potential of combined AXL and HDAC …
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