Accès ouvert
2026
article
OpenAlex
Gaetano Paride Arcidiacono, Marco Onofrio Torres, Chiara Ceolin, Mattia Giantin et autres
Abstract Hip fractures (HF) are among the most serious consequences of osteoporosis. Many individuals who subsequently sustain a HF may already fulfill recognized criteria for fracture risk assessment, bone mineral density (BMD) evaluation, or anti-osteoporosis treatment before the event occurs, yet remain …
it
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Accès ouvert
2026
article
OpenAlex
Carmine Zoccali, Giovanni Tripepi
BACKGROUND: Pragmatic clinical trials (PCTs) evaluate interventions under routine care conditions, prioritizing external validity and decision relevance over tightly controlled efficacy. Internal medicine, characterized by multimorbidity, polypharmacy, and heterogeneous care pathways, is a prime field for PCTs embedded in real-world practice. METHODS: …
it, us
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Accès ouvert
2026
article
OpenAlex
Alessia Placanica, Carmelo Pujia, R.M. Bruno, Rosy Conforto et autres
Background: Diet quality and amino acid intake influence both physical health and psychological well-being, potentially affecting eating disorder risk. This study aimed to investigate the relationship between dietary patterns, amino acid intake, and eating disorder risk. Methods: This cross-sectional study included 130 …
it
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Accès ouvert
2026
article
OpenAlex
Gaetano Paride Arcidiacono, Marco Onofrio Torres, Chiara Ceolin, Giovanni Tripepi et autres
PURPOSE: Vitamin D deficiency (VDD) is common in older adults with osteoporosis, but its prevalence, determinants, and clinical impact in hip fracture (HF) patients remain incompletely defined. This study investigated the prevalence of VDD, associated factors, and 12-month outcomes in HF patients …
it
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Accès ouvert
2026
article
OpenAlex
Vincenzo Calabrese, Giovanni Tripepi, Domenico Santoro, Valeria Cernaro et autres
Abstract Background Renin–angiotensin–aldosterone system inhibitors (RAASIs) are widely used antihypertensive drugs. Due to the hyperkalaemic effect, previous 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines discouraged RAASI use in patients with severe chronic kidney disease (CKD). However, due to the recently discovered …
it, nl, ro
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Accès ouvert
2025
article
OpenAlex
Gaetano Paride Arcidiacono, Marco Onofrio Torres, Francesca Zanchetta, Sofia Testoni et autres
Indolent systemic mastocytosis (ISM) is a rare cause of skeletal fragility. In this study, patients with ISM showed a markedly higher prevalence of biconcave vertebral fractures compared with primary osteoporosis. Assessing fracture morphology may aid in differentiating ISM, reducing diagnostic delay, and …
it
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Accès ouvert
2025
article
OpenAlex
Maria Luisa Brandi, Francesca Marini, Simone Parri, Stefania Bandinelli et autres
This cross-sectional study explored how vitamin D and the protein periostin are related to the risk of heart disease in elderly individuals. Lower levels of both were linked to higher risk of heart disease. The findings suggest these markers may help identify …
it, us
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Accès ouvert
2025
article
OpenAlex
Giovanni Tripepi, Graziella D’Arrigo
We read with great interest the recent paper by Campese (2025) [...]
it
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2025
article
OpenAlex
Carmine Zoccali, Giovanni Tripepi
The C statistic, also known as the concordance index (C-index), is widely used in clinical research to assess the discriminative ability of risk prediction models. Its appeal lies in its intuitive interpretation and broad applicability, particularly in fields such as cardiovascular medicine …
it, us, cz
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Accès ouvert
2025
article
OpenAlex
Carmine Zoccali, Giovanni Tripepi, Francesca Mallamaci, Franklin W. Maddux et autres
ABSTRACT Intradialytic hypotension (IDH) is a significant complication in haemodialysis (HD) patients, affecting cardiovascular stability and treatment outcomes. Antihypertensive medications, while crucial for blood pressure control, can exacerbate IDH, necessitating careful drug selection and management. This review highlights the differential effects at …
it, us, es, ua, de
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Accès ouvert
2025
article
OpenAlex
Chiara Martellino, Giuseppe Salafica, Giovanni Tripepi, Attilio Vinaccia et autres
BACKGROUND: Brivaracetam (BRV) is a third-generation antiseizure medication (ASM) that acts as a high-affinity ligand for synaptic vesicle protein 2A (SV2A), sharing a similar mechanism of action with levetiracetam (LEV). Nevertheless, BRV exhibits higher binding affinity and selectivity for SV2A and a …
it
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2025
article
OpenAlex
Maria Fusaro, Andrea Aghi, Maurizio Gallieni, Althea Cossettini et autres
Abstract Background and Aims Chronic kidney disease (CKD) often leads to mineral and bone disorders (CKD-MBD), which compromise bone quality and increase fracture risk. These bone complications frequently persist after kidney transplantation (K-Tx), primarily due to the lingering effects of pre-existing CKD-MBD. …
it, us
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