Dorota Neugebauer

Sequential Biofunctionalization of a Choline-Based Monomeric Ionic Liquid and Polymerized Ionic Liquid: A Route to Dual Anionic Drug Polymer Conjugates of Piperacillin−Tazobactam

Aleksy Mazur, Dorota Neugebauer

The choline-based monomeric ionic liquid (MIL), that is, [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMAMA), was modified by ion exchange to introduce a pharmaceutical anion (aspartic acid (APT), diclofenac (DIC), cholic acid (CHA), ibuprofen (IBU), nalidixic acid (NAL), naproxen (NAP), piperacillin (PIP), tazobactam (TAZ), and valproic …

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Graft Polymers Derived from Pharmaceutically Active Choline-Based Ionic Liquid Monomers: Dual Incorporation of Ampicillin and Cloxacillin

Aleksy Mazur, Dorota Neugebauer

This study reports the synthesis and characterization of well-defined ionic graft conjugates acting as drug delivery systems, based on monomeric ionic units derived from choline methacrylate (TMAMA) biofunctionalized with the anions of ampicillin (AMP) or cloxacillin (CLX). Using the "grafting from" technique …

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Author response for "Open-aired synthesis of star-shaped poly[2-(methacryloyloxy)ethyl trimethylammonium chloride]"

Tomasz Fronczyk, Anna Mielańczyk, Olesya Klymenko, Dorota Neugebauer

Open-aired synthesis of star-shaped poly[2-(methacryloyloxy)ethyl trimethylammonium chloride]

Tomasz Fronczyk, Anna Mielańczyk, Olesya Klymenko, Dorota Neugebauer

= 1.06-1.12) created thin hydrophilic films with thickness < 40 nm exhibiting water contact angle (WCA) values < 50°. Higher interfacial tension values obtained for star-shaped polymers in comparison with the linear analog indicate that surface wettability can be modified by changing …

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Projektowanie innowacyjnych nanonośników polimerowych na bazie cholinowych cieczy jonowych do współdostarczania związków bioaktywnych

Katarzyna Niesyto, Shadi Keihankhadiv, Aleksy Mazur, Dorota Neugebauer

Enzyme-mediated polymerization : building tomorrow’s materials today

Tomasz Fronczyk, Anna Mielańczyk, Dorota Neugebauer

Materiały przyszłości. T. 2

Ayesha Amjad, Ammara Aslam, Marcin Basiaga, Jerzy Bodzenta et autres

Polymerizable Cholinium-Based Antibiotics for Polymer Carriers: Systems with Combined Load of Cloxacillin and Ampicillin

Shadi Keihankhadiv, Dorota Neugebauer

Single and dual-drug delivery systems (DDSs) based on linear choline polymers were designed through the controlled polymerization of a pharmaceutically functionalized monomer, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium, with counterions of cloxacillin (TMAMA/CLX), or its copolymerization with [2-(methacryloyloxy)ethyl]trimethylammonium with ampicillin (TMAMA/AMP), providing antibiotic properties. This strategy …

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Simple strategy of the use of pharmaceutically functionalized ionic liquids in a new generation of polymer nanocarriers for the combined delivery of ionic p-aminosalicylate and ampicillin

Shadi Keihankhadiv, Dorota Neugebauer

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Linear copolymers based on cholinium functionalized with antibiotic anions for single– and dual–drug delivery systems

Shadi Keihankhadiv, Dorota Neugebauer

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From Facile One-Pot Synthesis of Semi-Degradable Amphiphilic Miktoarm Polymers to Unique Degradation Properties

Maria Kupczak, Anna Mielańczyk, Tomasz Fronczyk, Patryk Drejka et autres

We report a one-pot synthesis of well-defined A5B and A8B miktoarm star-shaped polymers where N,N-dimethylaminoethyl methacrylate (DMAEMA) and various cyclic esters such as ε-caprolactone (ε-CL), lactide (LA) and glycolide (GA) were used for the synthesis. Miktopolymers were obtained by simultaneously carrying out …

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Photoresponse of new azo pyridine functionalized poly(2-hydroxyethyl methacrylate-co-methyl methacrylate)

Jolanta Konieczkowska, Dorota Neugebauer, Anna Kozanecka‐Szmigiel, Aleksy Mazur et autres

Abstract A new azo polymer containing photoisomerizable azo pyridine functionalities was synthesized via Mitsunobu reaction of 4-(4-hydroxyphenylazo)pyridine with poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) for creating new photochromic materials. The resulting polymer with azo pyridine side groups was characterized for structural, thermal, and optical …

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