Rafael Struck

The ATLAS/NOA-29 study protocol: a phase III randomized controlled trial of anterior temporal lobectomy versus gross-total resection in newly-diagnosed temporal lobe glioblastoma

Matthias B. Schneider, Anna‐Laura Potthoff, Yahya Ahmadipour, Valeri Borger et autres

BACKGROUND: The discovery of cellular tumor networks in glioblastoma, with routes of malignant communication extending far beyond the detectable tumor margins, has highlighted the potential of supramarginal resection strategies. Retrospective data suggest that these approaches may improve long-term disease control. However, their …

de, ch, at, us (code pays fourni par la source)

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

Sabine Westphal, Christian Stoppe, Matthias Gruenewald, Berthold Bein et autres

The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, …

de (code pays fourni par la source)

Prospective observational cohort study on grading the severity of postoperative complications in global surgery research

Tom E.F. Abbott, Kathryn Greaves, Aditya Umeshkumar Patel, Tahania A Ahmad et autres

BACKGROUND: The Clavien-Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien-Dindo system can be used internationally in studies across …

gb, fr (code pays fourni par la source)

Prospective observational cohort study of the association between antiplatelet therapy, bleeding and thrombosis in patients with coronary stents undergoing noncardiac surgery

Simon James Howell, Sanne Elisabeth Hoeks, Robert Michael West, Stephen G. Wheatcroft et autres

BACKGROUND: The perioperative management of antiplatelet therapy in noncardiac surgery patients who have undergone previous percutaneous coronary intervention (PCI) remains a dilemma. Continuing dual antiplatelet therapy (DAPT) may carry a risk of bleeding, while stopping antiplatelet therapy may increase the risk of …

gb, nl, de, be, fr, gr, xk, lt, pt, ro, es, tr (code pays fourni par la source)

Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

Eva Kirmeier, Lars I. Eriksson, Heidrun Lewald, Malin Jonsson Fagerlund et autres

de, se, nl, gb (code pays fourni par la source)

The surgical safety checklist and patient outcomes after surgery: a prospective observational cohort study, systematic review and meta-analysis

Tom E.F. Abbott, T. Ahmad, M. Phull, A.J. Fowler et autres

gb, au, Afrique du Sud, se (code pays fourni par la source)

Effect of remote ischemic preconditioning on the melatonin and antioxidative status: a pilot study in patients undergoing cardiac surgery

Rafael Struck, Mária Wittmann, Thomas Recht, Georg Baumgarten et autres

BACKGROUND: Remote ischemic preconditioning (RIPC), a phenomenon in which a transient ischemia applied to a nonvital tissue protects another organ or tissue from subsequent lethal ischemic injury, is reported to protect the myocardium to withstand a subsequent prolonged ischemic event in patients …

de (code pays fourni par la source)

Effect of Remote Ischemic Preconditioning on Intestinal Ischemia-Reperfusion Injury in Adults Undergoing On-Pump CABG Surgery: A Randomized Controlled Pilot Trial

Rafael Struck, Mária Wittmann, Stefan C. Müller, Patrick Meybohm et autres

de (code pays fourni par la source)

Cost-efficiency of knowledge creation

Rafael Struck, Georg Baumgarten, Mária Wittmann

PURPOSE OF REVIEW: This article reviews traditional and current perspectives on randomized, controlled trials (RCTs) and observational studies relative to the economic implications for public healthcare stakeholders. RECENT FINDINGS: It takes an average of 17 years to bring 14% of original research …

de (code pays fourni par la source)

Ultrasound-Mediated Stimulation of Microbubbles after Acute Myocardial Infarction and Reperfusion Ameliorates Left-Ventricular Remodelling in Mice via Improvement of Borderzone Vascularization

Jonas Dörner, Rafael Struck, Sebastian Zimmer, Christine Peigney et autres

AIMS: Post-infarction remodelling (PIR) determines left-ventricular (LV) function and prognosis after myocardial infarction. The aim of this study was to evaluate transthoracic ultrasound-mediated microbubble stimulation (UMS) as a novel gene- and cell-free therapeutic option after acute myocardial infarction and reperfusion (AMI/R) in …

de, ch (code pays fourni par la source)

Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair

Sebastian Schlaweck, Sebastian Zimmer, Rafael Struck, Eva Bartok et autres

de (code pays fourni par la source)

Neuroarchitecture of Peptidergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster

Jonathan G. Santos, Matthias Vömel, Rafael Struck, Uwe Homberg et autres

Recent studies on Drosophila melanogaster and other insects have revealed important insights into the functions and evolution of neuropeptide signaling. In contrast, in- and output connections of insect peptidergic circuits are largely unexplored. Existing morphological descriptions typically do not determine the exact …

de, se (code pays fourni par la source)