Reinhard Bauer

Membrane lipid composition and rapid endocytic retrieval modulate Wingless secretion

Ines Alvarez‐Rodrigo, David Willnow, Cyrille Alexandre, Claire Lebarbenchon et autres

The Wnt family ligands carry a lipid moiety that must be shielded from the aqueous environment. During secretion, this is achieved by the cargo receptor Wntless. The effect of acute endocytosis inhibition suggests that Wingless dissociates from Wntless at the apical plasma …

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Membrane lipid composition and endocytosis modulate Wingless release from secreting cells

Ines Alvarez‐Rodrigo, David Willnow, Cyrille Alexandre, Claire Lebarbenchon et autres

gb, de, fr (code pays fourni par la source)

Genetic interaction approaches reveal emerging roles of innexins in development : Insights from a novel pannier–innexin-2 interaction during Drosophila embryogenesis

Spraha Bhandari, Franka Eckardt, Reinhard Bauer

Abstract Effective communication between cells is essential for the typical development and behaviour of an organism. In this context, gap junctions represent the most universally preserved components at cellular membranes of multicellular organisms, facilitating metabolic and electrical connections between cells. Disruptions in …

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Membrane lipid composition and endocytosis modulate Wingless release from secreting cells

Ines Alvarez‐Rodrigo, David Willnow, Cyrille Alexandre, Claire Lebarbenchon et autres

Abstract Wnts are secreted signalling molecules that regulate development and adult homeostasis. Most Wnts carry a lipid moiety that must be shielded from the aqueous environment. In the secretory pathway, this is achieved by a hydrophobic tunnel in Wntless, a multipass transmembrane …

gb, de, fr (code pays fourni par la source)

Spatial Expression Pattern and Cellular Organization of Gap Junctions in Third Instar Wing Imaginal Discs of Drosophila melanogaster

Spraha Bhandari, Ankita Chodankar, Franka Eckardt, Reinhard Bauer

Abstract The Drosophila wing imaginal disc serves as a powerful model to study intercellular communication during development. In our study, we report and discuss the expression pattern and cellular distribution of innexin-1, innexin-2 and innexin-3 in the cells of the wing imaginal …

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Individual lipid alterations at the origin of neuronal Ceramide Synthase defects

Anna B. Ziegler, Cedrik Wesselmann, Konstantin Beckschäfer, Anna‐Lena Wulf et autres

The brain is highly susceptible to disturbances in lipid metabolism. Among the rare, genetically-linked epilepsies Progressive Myoclonic Epilepsy Type 8 (PME8), associated with the loss of Ceramide Synthase (CerS) activity, causes epileptic symptoms accompanied by early onset of neurodegenerative traits. The function …

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Targeting the homeodomain of ceramide-synthase can ameliorate insulin resistance

Christian Vera-Granda, Mariangela Sociale, Konstantin Beckschäfer, Ilja Kanevskij et autres

Abstract Multiple studies have linked ceramide accumulation with insulin resistance and diabetes. Ceramide Synthases (CerS) are at the center of ceramide de novo formation. Impaired CerS activity leads to lower ceramide and resolves insulin resistance. Drosophila has only one CerS, named Schlank, …

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Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner

Seyhmus Bayar, Lea Seep, Karolína Doubková, Jelena Zurkovic et autres

Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative disorders. To investigate the intergenerational effects of maternal obesity, we used Drosophila melanogaster exposed to high-sugar (HSD) and high-fat diets (HFD) before mating. We …

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Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila

Benjamin Boumard, Gwenn Le Meur, Laïla Aboutine, Marine Stefanutti et autres

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Lipid Disbalance Affects Neuronal Dendrite Growth and Maintenance in a Human Ceramide Synthase Disease Model

Anna B. Ziegler, Cedrik Wesselmann, Konstantin Beckschaefer, Anna‐Lena Wulf et autres

Summary The brain is susceptible to disturbances in lipid metabolism. Among the rare, genetically-linked epilepsies Progressive Myoclonic Epilepsy Type 8 (PME8), associated with the loss of Ceramide Synthase (CerS) activity, causes epileptic symptoms accompanied by neurodegenerative traits. We show that expression of …

de (code pays fourni par la source)

Loss of ceramide synthase 5 inhibits the development of experimentally induced aortic valve stenosis

Laurine Reese, Sven Thomas Niepmann, Philip Düsing, Lea Hänschke et autres

AIM: Inflammation and calcification are hallmarks in the development of aortic valve stenosis (AVS). Ceramides mediate inflammation and calcification in the vascular tissue. The highly abundant d18:1,16:0 ceramide (C16) has been linked to increased cardiovascular mortality and obesity. In this study, we …

de (code pays fourni par la source)

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress

Benjamin Boumard, Gwenn Le Meur, Tania Maalouf, Marwa El-Hajj et autres

Cell proliferation underlying tissue growth and homeostasis, requires high levels of metabolites such as deoxynucleotides (dNTPs). The dNTP pool is known to be tightly cell-autonomously regulated via de novo synthesis and salvage pathways. Here, we reveal that nucleotides can also be provided …

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