Jahaun Azadmanesh

High-resolution X-ray structure of Gln143Asn manganese superoxide dismutase captures multiple hydrogen peroxide-binding sites

Medhanjali Dasgupta, Erika A. Cone, Jahaun Azadmanesh, Thomas Kröll

Human mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide into hydrogen peroxide and molecular oxygen, serving as a key defence against oxidative damage. Despite extensive studies, the full structural characterization of H 2 O 2 -binding sites in MnSOD remains largely unexplored. Previous …

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The role of Tyr34 in proton coupled electron transfer and product inhibition of manganese superoxide dismutase

Jahaun Azadmanesh, Lucas R. Struble, Jeffrey J. Lovelace, Erika A. Cone et autres

Human manganese superoxide dismutase (MnSOD) plays a crucial role in controlling levels of reactive oxygen species (ROS) by converting superoxide ( $${{{{\rm{O}}}}}_{2}^{\bullet -}$$ ) to molecular oxygen (O2) and hydrogen peroxide (H2O2) with proton-coupled electron transfers (PCETs). A key catalytic residue, Tyr34, …

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Mapping the Exit Route of Hydrogen Peroxide from the Manganese Superoxide Dismutase (Mnsod) Active Site

Medhanjali Dasgupta, Erika A. Cone, Jahaun Azadmanesh, Thomas Kröll

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Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition

Jahaun Azadmanesh, Lucas R. Struble, William E. Lutz, Leighton Coates et autres

Abstract Human manganese superoxide dismutase (MnSOD) is a crucial oxidoreductase that maintains the vitality of mitochondria by converting superoxide (O 2 ●− ) to molecular oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) with proton-coupled electron transfers (PCETs). …

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The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase

Jahaun Azadmanesh, Lucas R. Struble, Erika A. Cone, Medhanjali Dasgupta et autres

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The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase

Jahaun Azadmanesh, Lucas R. Struble, Erika A. Cone, Medhanjali Dasgupta et autres

ABSTRACT Human manganese superoxide dismutase (MnSOD) plays a crucial role in controlling levels of reactive oxygen species (ROS) by converting superoxide (O 2 •− ) to molecular oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) with proton-coupled electron …

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Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition

Jahaun Azadmanesh, Lucas R. Struble, William Lutz, Leighton Coates et autres

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Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition

Jahaun Azadmanesh, Lucas R. Struble, William Lutz, Leighton Coates et autres

ABSTRACT Human manganese superoxide dismutase (MnSOD) is a crucial oxidoreductase that maintains the vitality of mitochondria by converting O 2 ●- to O 2 and H 2 O 2 with proton-coupled electron transfers (PCETs). Since changes in mitochondrial H 2 O 2 …

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Visualization of the human manganese superoxide dismutase product inhibition mechanism and protonation states

Jahaun Azadmanesh, William E. Lutz, Leighton Coates, Kevin L. Weiss et autres

About 25% of known enzymes are oxidoreductases that catalyze the electron transfers that life depends on.To chemically accelerate redox reactions to the rates needed for life, oxidoreductases couple the transfer of electrons to the transfer of protons in a process called proton-coupled …

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Perfect Crystals: microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography

William E. Lutz, Jahaun Azadmanesh, Jeffrey J. Lovelace, Carol Kolar et autres

The NASA mission Perfect Crystals used the microgravity environment on the International Space Station (ISS) to grow crystals of human manganese superoxide dismutase (MnSOD)-an oxidoreductase critical for mitochondrial vitality and human health. The mission's overarching aim is to perform neutron protein crystallography …

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The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis

Jahaun Azadmanesh, Mohamed A. Seleem, Lucas R. Struble, Nicholas A. Wood et autres

Chlamydia trachomatis (ct) is the most reported bacterial sexually transmitted infection worldwide and the leading cause of preventable blindness. Caseinolytic proteases (ClpP) from pathogenic bacteria are attractive antibiotic targets, particularly for bacterial species that form persister colonies with phenotypic resistance against common …

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Perfect Crystals: Microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography

William E. Lutz, Jahaun Azadmanesh, Jeffrey J. Lovelace, Carol Kolar et autres

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