Devika Chawla

Outcomes and Management of Pregnancies Screening Positive for Microdeletions 22q11.2, 15q11.2, 1p36, 4p, or 5p: A Retrospective Cohort Study

D. Claire Miller, Devika Chawla, Summer Pierson, Katherine Johansen Taber

Purpose: To compare pregnancy outcomes and management between patients screening positive for five microdeletions (microdeletion screen-positive, MDS+) and patients screening negative (microdeletion screen-negative, MDS-). Patients and Methods: Patients who received a prenatal cell-free DNA (pcfDNA) test that screens for microdeletions 22q11.2, 15q11.2, …

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Outcomes and Management of Pregnancies Screening Positive for Microdeletions 22q11.2, 15q11.2, 1p36, 4p, or 5p: A Retrospective Cohort Study

Miller DC, Devika Chawla, Summer Pierson, Johansen Taber K

D Claire Miller, Devika Chawla, Summer Pierson, Katherine Johansen Taber Clinical Development, Myriad Genetics, Inc., Salt Lake City, UT, USACorrespondence: D Claire Miller, Clinical Development, Myriad Genetics, Inc., 322 N 2200 W, Salt Lake City, UT, 84116, USA, Tel +1 801 584-3600, …

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Real-World Impact of Pharmacogenomic Testing on Medication Use and Healthcare Resource Utilization in Patients With Major Depressive Disorder

Andria Lee Del Tredici, Holly L. Johnson, Brady DeHart, Alexander Gutin et autres

BACKGROUND: Pharmacogenomic (PGx) testing can help improve response and remission rates for patients with major depressive disorder (MDD) and at least one treatment failure. To investigate real-world outcomes, we examined 1) significant gene-drug interactions (GDIs) and 2) healthcare resource utilization (HRU) in …

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Screening Positive for Rare Autosomal Aneuploidies Increases Frequency of Adverse Pregnancy Outcomes and Alters Clinical Management

Devika Chawla, D. Claire Miller, Summer Pierson, Lyuba Popadic et autres

OBJECTIVE: Outcomes in pregnancies with rare autosomal aneuploidies (RAAs) are poorly characterized, with most studies having small sample sizes. Here, we describe outcomes and management in a large cohort of pregnancies that screened positive for an RAA (RAA+). METHODS: Results of prenatal …

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Association of polygenic-based breast cancer risk prediction with patient management.

Katie Johansen Taber, Elisha Hughes, Alexander Gutin, Brady DeHart et autres

10527 Background: Guidelines recommend individuals with ≥20% lifetime risk of breast cancer (BC) undergo enhanced management, including annual screening mammography (SM) as early as age 30, annual breast MRI, and genetic counseling (GC). Lifetime BC risk can be estimated using a validated …

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High positive predictive value 22q11.2 microdeletion screening by prenatal cell‐free DNA testing that incorporates fetal fraction amplification

Carly Hammer, Summer Pierson, Ashley Acevedo, Thomas Westover et autres

OBJECTIVE: 22q11.2 deletion syndrome (DS) is a serious condition with a range of features. The small microdeletion causing 22q11.2DS makes it technically challenging to detect using standard prenatal cfDNA screening. Here, we assess 22q11.2 microdeletion clinical performance by a prenatal cfDNA screen …

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The Smallness of Things

Devika Chawla

My first journey begins with oral history work on India’s Partition which took me on seven transatlantic field trips to record oral histories of three generations of Partition refugee families in Delhi, in northern India. These were families like my own, a …

194 Fetal fraction amplification dramatically increases PPV for 22q11.2 deletion syndrome in prenatal cell-free DNA screening

Carly Hammer, Summer Pierson, Devika Chawla, Sarah Ratzel et autres

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Configuring a Post‐ and Decolonial Pedagogy

Devika Chawla

This chapter is a pedagogical self-inventory in which I illuminate one way that I use a postcolonial studies seminar to highlight the intersections of theory, method, and pedagogy in critical studies in communication. My goal is to share how I wrestle with …

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Race, Language, and Transculturalism

Devika Chawla

“I Have English” is an experimental attempt to commingle theory, memoir, criticism, what some call autotheory and others call autoethnography. Or it is a rage essay about Whiteness, racism, and other assorted oppressions that beset Brown and Black female bodies in the …

Interactive Management Research in Organizational Communication

Robert John Razzante, Michael Hogan, Benjamin J. Broome, Sarah J. Tracy et autres

In this research methods essay, we describe Interactive Management Research (IMR), a participatory action research methodology with extensive applications in organizational settings but new to organizational communication research. IMR offers possibilities as a participant-centered methodology that is particularly well suited for complex …

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P627: Early performance analysis for 22q11.2 deletion syndrome detection using a whole-genome sequencing-based noninvasive prenatal screen

Summer Pierson, Carly Hammer, Devika Chawla, Sarah Ratzel et autres

Introduction: An essential tool for reproductive health, non-invasive prenatal screening (NIPS) allows for risk assessment of fetal genetic disorders by testing circulating fetal and maternal cell-free DNA (cfDNA) in maternal blood.The proportion of fetal DNA, the fetal fraction, can be as low …

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