Matteo Lenge

Case Report of Recovery from Cortical Blindness in a Child with POLG1-Related Disease: A Three-Month Follow-Up

Tiziana Metitieri, Giulia Savoca, Luca Bartolini, Silvia Savazzi et autres

Recovery from complete cortical blindness is rarely documented in children. We report an 8-year-old with cortical blindness due to POLG1-related mitochondrial disease and status epilepticus. Initial presentation involved complete visual loss for about one month. Early recovery began with conscious color perception, …

il, it (code pays fourni par la source)

Associations of Cortical and Subcortical White Matter Morphometric Abnormalities With Clinical and Genetic Findings in STXBP1 Encephalopathy

Matteo Lenge, Alice Dainelli, Simona Balestrini, Simona Fiori et autres

Background and Objectives: ) gene are among the most common genetic causes of developmental and epileptic encephalopathies and are associated with a wide phenotypic spectrum. Qualitative neuroimaging studies are usually unrevealing or uncover variable MRI findings, including cortical atrophy, thin/dysmorphic corpus callosum …

it, au (code pays fourni par la source)

Enhanced detection of subtle cortical abnormalities in focal epilepsy using 7 T MRI surface-based models and graph neural networks

Matteo Lenge, Simona Fiori, Pietro Cappelletto, Andrea Droghini et autres

PURPOSE: MRI detection of subtle focal cortical dysplasia (FCD)-like abnormalities remains challenging in focal epilepsy. Higher signal-to-noise ratio and spatial resolution offered by ultra-high-field 7T MRI and surface-based graph-neural-network (GNN) analysis may improve detection of subtle cortical abnormalities. We evaluated whether combining …

it (code pays fourni par la source)

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study

Heath R Pardoe, Orrin Devinsky, Jemima Robson, Molly Ireland et autres

Introduction: Brain structural differences consistent with an older-appearing brain have been reported in people with epilepsy, but the extent to which these differences reflect clinical characteristics vs broader socioeconomic context is unclear. We investigated whether country-level socioeconomic factors are associated with neuroanatomical …

au, us, be, gb, br, it, de, ca, Kenya, mx, ch, Afrique du Sud, cn (code pays fourni par la source)

Effective correction of extreme capacitive artifacts in TMS-EEG via windowed detrending

Alberto Arturo Vergani, G Peroni, Camilla Bruscagli, Alessia Lionti et autres

Abstract Objective. transcranial magnetic stimulation (TMS) combined with electroencephalography enables non-invasive assessment of cortical excitability and connectivity through TMS-evoked potentials (TEPs), but it is highly susceptible to artifacts that can obscure genuine neural activity. Among these, capacitive artifacts at the electrode-scalp interface …

it, gb (code pays fourni par la source)

Disease detection and classification in temporal lobe epilepsy: step-wise versus simultaneous AI decision models in a multisite neuroimaging study

Erik Kaestner, Jay Sawant, Donatello Arienzo, Kyle Hasenstab et autres

Abstract Diagnostic MRI evaluation of temporal lobe epilepsy (TLE) depends on the subjective visual interpretation of MRI images. These interpretations could be enhanced by quantitative artificial intelligence (AI) support tools. Humans often make sequential and conditional decisions during their radiological interpretations, such …

us, br, ie, gb, de, it, be, ca, ch, il, au, Afrique du Sud, mx, cn (code pays fourni par la source)

Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy

Judy Chen, Alexander Ngo, Raúl Rodríguez‐Cruces, Jessica Royer et autres

BACKGROUND AND OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of gray and white matter structures. Evidence supports a progressive condition, although the temporal evolution of TLE is poorly defined. In this ENIGMA-Epilepsy study, we aim …

Real‐world evidence in pediatrics

Mattia Giovannini, Francesco Catamerò, Ioana Agache, Antonio Bognanni et autres

MG reports personal fees from Sanofi, Thermo Fisher Scientific.

it, ro, us, gr, pt, gb (code pays fourni par la source)

High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex

Sofia Avalos-Alais, Maciej Jedynak, Anthony Boyer, Blandine Chanteloup-Forêt et autres

The lateral prefrontal cortex (LPFC) serves as a critical hub for higher-order cognitive and executive functions in the human brain, coordinating brain networks whose disruption has been implicated in many neurological and psychiatric disorders. While transcranial brain stimulation treatments often target the …

fr, us, ch (code pays fourni par la source)

Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy

Judy Chen, Alexander Ngo, Raúl Rodríguez‐Cruces, Jessica Royer et autres

BACKGROUND AND OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of gray and white matter structures. Evidence supports a progressive condition, although the temporal evolution of TLE is poorly defined. In this ENIGMA-Epilepsy study, we aim …

ca, it, mx, gb, br, us, de, ch, au, ie, fi, ir, cn, be (code pays fourni par la source)

Associations between epilepsy-related polygenic risk and brain morphology in childhood

Alexander Ngo, Lang Liu, Sara Larivière, Valeria Kebets et autres

Extensive neuroimaging research in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) has identified brain atrophy as a disease phenotype. While it is also related to a complex genetic architecture, the transition from genetic risk factors to brain vulnerabilities remains unclear. Using a …

ca, de, cn, sg, us, it, mx, gb, br, au, fi, ir, dk, il, ch, si (code pays fourni par la source)

Focal Cortical Dysplasia Type II Detection Using Cross Modality Transfer Learning and Grad-CAM in 3D-CNNs for MRI Analysis

Lorenzo Lasagni, A. Ciccarone, Renzo Guerrini, Matteo Lenge et autres

Focal cortical dysplasia (FCD) type II is a major cause of drug-resistant epilepsy, often curable only by surgery. Despite its clinical importance, the diagnosis of FCD is very difficult in MRI because of subtle abnormalities, leading to misdiagnosis. This study investigates the …