Samantha O’Keeffe

Stage-Dependent Metabolic Responses to Oral Nutritional Supplementation in Cancer Cachexia: A Single-Arm Pilot Study

sora kang, H. Sim, Samantha O’Keeffe, JUNYOUNG PARK et autres

Background/Objectives: Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss and muscle wasting, leading to impaired quality of life and poor clinical outcomes. Although oral nutritional supplements (ONS) are recommended to support inadequate oral intake during chemotherapy, their effects on …

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High energy charge, antioxidant capacity, and amino acid contents are conserved features of T cell metabolism

Samantha O’Keeffe, H. Sim, Elle McCue, Junyoung O. Park

Abstract T cell diversity and differentiation define individual adaptive immunity. Metabolism fuels adaptive immunity by driving proliferation, differentiation, and activation; however, how individual and lineage differences shape T cell metabolism remains unknown. Here we develop an ensemble method for absolute metabolome quantitation …

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Bringing carbon to life via one-carbon metabolism

Samantha O’Keeffe, Lilly Garcia, Yi Chen, Richard C. Law et autres

One-carbon (C1) compounds found in greenhouse gases and industrial waste streams are underutilized carbon and energy sources. While various biological and chemical means exist for converting C1 substrates into multicarbon products, major challenges of C1 conversion lie in creating net value. Here, …

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Integrated Proteomics and Metabolomics Reveal Altered Metabolic Regulation of Xanthobacter autotrophicus under Electrochemical Water-Splitting Conditions

Zachary D. Schuman, Yongchao Xie, Samantha O’Keeffe, Xun Guan et autres

Biological–inorganic hybrid systems are a growing class of technologies that combine microorganisms with materials for a variety of purposes, including chemical synthesis, environmental remediation, and energy generation. These systems typically consider microorganisms as simple catalysts for the reaction of interest; however, other …

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Neutrophil diversity is associated with T-cell immunity and clinical relevance in patients with thyroid cancer

Seong Eun Lee, Bon Seok Koo, Pureum Sun, Shinae Yi et autres

Abstract Neutrophil heterogeneity is involved in autoimmune diseases, sepsis, and several cancers. However, the link between neutrophil heterogeneity and T-cell immunity in thyroid cancer is incompletely understood. We investigated the circulating neutrophil heterogeneity in 3 undifferentiated thyroid cancer (UTC), 14 differentiated thyroid …

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Integrated Proteomics and Metabolomics reveal altered metabolic regulation of Xanthobacter autotrophicus under electrochemical water-splitting conditions

Zachary D. Schuman, Yongchao Xie, Samantha O’Keeffe, Xun Guan et autres

Biological-inorganic hybrid systems are a growing class of technologies that combine microorganisms with materials for many purposes including chemical synthesis, environmental remediation, and energy generation. Recently, hybrid systems have been developed toward the sustainable generation of value-added chemicals from the plentiful and …

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The role of neutrophil heterogeneity on T-cell immunity and prognosis in thyroid cancer patients

Yea Eun Kang, Seong Eun Lee, Bon Seok Koo, Pureum Sun et autres

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Accurate and rapid determination of metabolic flux by deep learning of isotope patterns

Richard C. Law, Samantha O’Keeffe, Glenn Nurwono, Rachel Ki et autres

Abstract All life forms operate metabolism in constant flux. Metabolic fluxes offer a direct readout of cellular state, detailing the rates and driving forces of metabolic pathways. However, indirect, iterative solvers for mapping isotope patterns from tracing experiments onto metabolic fluxes leave …

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Sustainable metabolic engineering requires a perfect trifecta

Glenn Nurwono, Samantha O’Keeffe, Nian Liu, Junyoung O. Park

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Integrative metabolic flux analysis reveals an indispensable dimension of phenotypes

Richard C. Law, Aliya Lakhani, Samantha O’Keeffe, Sevcan Erşan et autres

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Light‐Emitting Conjugated Polymers: Fundamentals of Materials Selection for Light‐Emitting Electrochemical Cells (Adv. Funct. Mater. 33/2020)

Kareem Youssef, Ying Li, Samantha O’Keeffe, Lu Li et autres

The operation of polymer light-emitting electrochemical cells requires electronic, luminescent, and ionic ingredients that work synergistically in the devices. In article number 1909102, Lu Li, Qibing Pei, and co-workers discuss the mechanisms behind the junction formation and stabilization to create efficient and …

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Fundamentals of Materials Selection for Light‐Emitting Electrochemical Cells

Kareem Youssef, Ying Li, Samantha O’Keeffe, Lu Li et autres

Abstract The in situ formation of a light‐emitting p–n or p–i–n junction in light‐emitting electrochemical cells (LECs) necessitates mixed ionic–electronic conductors in the active layer. This unique characteristic requires electronic, luminescent, and ionic ingredients that work synergistically in the LECs. The material …

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