Accès ouvert
2025
article
OpenAlex
Qinghao Zhang, Fnu Aapjeet, Joyce Chen, Xiaoyan Tang et autres
Proteolytic degradation of recombinant proteins in Chinese hamster ovary (CHO) cells remains a major challenge in biopharmaceutical manufacturing, often reducing product yield and quality. Matriptase-1, a type II transmembrane serine protease, has been identified as a key contributor to unwanted proteolysis. This …
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2024
paratext
OpenAlex
Yixiao Zhang, Sri Ranganayaki Madabhushi, Tiffany Pooi Ling Tang, Hassan Raza et autres
The cover image is based on the Research Article Contributions of Chinese hamster ovary cell derived extracellular vesicles and other cellular materials to hollow fiber filter fouling during perfusion manufacturing of monoclonal antibodies by Yixiao Zhang et al., https://doi.org/10.1002/bit.28674.
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Accès ouvert
2024
article
OpenAlex
Yixiao Zhang, Sri Ranganayaki Madabhushi, Tiffany Pooi Ling Tang, Hassan Raza et autres
Hollow fiber filter fouling is a common issue plaguing perfusion production process for biologics therapeutics, but the nature of filter foulant has been elusive. Here we studied cell culture materials especially Chinese hamster ovary (CHO) cell-derived extracellular vesicles in perfusion process to …
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2022
article
OpenAlex
David J. Busch, Yixiao Zhang, Amit Kumar, Steven C. Huhn et autres
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Accès ouvert
2021
article
OpenAlex
Victoria Le, Mei G. Lei, Peter L. Voyvodic, Chi Zhao et autres
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2020
conference-abstract
OpenAlex
Mei G. Lei, Victoria Le, Peter L. Voyvodic, Chi Zhao et autres
Syndecan-1 (SDC1) is a transmembrane proteoglycan that mediates the shear stress-induced signaling and inflammatory phenotypes of endothelial cells. While SDC1 is known to be involved mechanically in regulating the behavior of cells, it remains unknown how SDC1 responds to extracellular mechanical cues …
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Accès ouvert
2020
preprint
OpenAlex
Victoria Le, Mei G. Lei, Peter L. Voyvodic, Chi Zhao et autres
Abstract The endothelium plays a central role in regulating vascular homeostasis and is key in determining the response to materials implanted in the vascular system. Endothelial cells are uniquely sensitive to biophysical cues from applied forces and their local cellular microenvironment. The …
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Accès ouvert
2020
article
OpenAlex
Susan M. L. Banks, Audrey T. Medeiros, Molly McQuillan, David J. Busch et autres
Abstract α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presynapses where the protein is normally localized. While it …
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(code pays fourni par la source)
2019
conference-abstract
OpenAlex
Victoria Le, Mei G. Lei, Peter L. Voyvodic, Chi Zhao et autres
Syndecan-1 (SDC-1) is a transmembrane cell surface proteoglycan known to play a role in flow sensation in the glycocalyx of arteries and to control the inflammatory phenotype of endothelial cells. It is currently unknown whether SDC-1 directly responds to applied forced or …
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Accès ouvert
2019
preprint
OpenAlex
Susan M. L. Banks, Audrey T. Medeiros, Molly McQuillan, David J. Busch et autres
ABSTRACT α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presynapses where the protein is normally localized. While it …
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(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Andre C.M. DeGroot, David J. Busch, Carl C. Hayden, Samuel A. Mihelic et autres
us
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Accès ouvert
2018
article
OpenAlex
Andre DeGroot, David J. Busch, Carl C. Hayden, Samuel A. Mihelic et autres
us
(code pays fourni par la source)