Ahmad Hamad Alhowail

Short-term effects of alcohol detoxification on cardiovascular, hematological, and oxidative stress biomarkers: A prospective cohort study

Ashraf M. Emara, Anoud Maseer Ateeq Alshammari, Ahmad Hamad Alhowail, Rehab Mohamed Elgharabawy

INTRODUCTION: Chronic alcohol consumption induces multisystem dysfunction, including cardiovascular instability, hematological alterations, and oxidative stress imbalance. However, the extent of short-term recovery following structured detoxification remains incompletely characterized. OBJECTIVE: To evaluate the short-term effects of a standardized inpatient alcohol detoxification protocol on …

sa, Égypte (code pays fourni par la source)

β-Glucan Mitigates Valproic Acid-Induced Hepatorenal Toxicity in Rats

Maha Mohammad Almutairi, Hussein Mohammad Ali, Mohamed Abdelbakky, Ahmad Hamad Alhowail et autres

Valproic acid (VPA) is a common medication used to treat epilepsy, known for its broad-spectrum efficacy but also associated with hepatotoxicity and metabolic disturbances. β-glucan, a natural polysaccharide with hepatoprotective properties, may mitigate drug-induced liver damage. The study sought to assess hepatorenal …

sa, Égypte (code pays fourni par la source)

Paclitaxel-induced cognitive impairment: mechanistic insights

Ahmad Hamad Alhowail

Paclitaxel, a cornerstone taxane for solid-tumor chemotherapy, frequently precipitates long-lasting cognitive deficits, which are collectively termed chemotherapy-related cognitive impairment and often referred to as chemobrain or chemofog. Although the precise mechanisms are still being fully elucidated, a growing body of evidence from …

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Exploring how levetiracetam mitigates toxicity and ameliorates memory impairment

Ahmad Hamad Alhowail

Cognitive impairment encompasses a spectrum of deficits that markedly affect daily functioning and quality of life. Understanding the specific cognitive domains involved is thus crucial for developing targeted interventions and effective support strategies. This impairment ranges from mild cognitive decline to severe …

sa (code pays fourni par la source)

Ineffectiveness of pioglitazone in cognitive impairment induced by cyclophosphamide, methotrexate, and fluorouracil via oxidative stress and neuroinflammation

Ahmad Hamad Alhowail

Research objective: Chemotherapy is frequently linked to enduring cognitive impairments in individuals who have survived cancer. The cyclophosphamide, methotrexate, and fluorouracil (CMF) regimen is a standard protocol in cancer treatment. Pioglitazone (PGZ), an oral medication used to treat diabetes, has demonstrated neuroprotective …

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Reprogramming the hepatic immune microenvironment with mirtazapine in early neoplastic transformation: Evidence from a diethylnitrosamine-induced rat model

Elsayed A. Elmorsy, Sameh Saber, Ahmad Hamad Alhowail, Abousree Taha Ellethy et autres

sa, Égypte (code pays fourni par la source)

Ineffectiveness of tirzepatide in mitigating Doxorubicin-induced oxidative stress and cognitive deficits in a rat model

Salma Alolayan, Ahmad Hamad Alhowail

Doxorubicin (DXN) is widely utilized for the treatment of various cancer types. However, prolonged DXN administration induces vascular impairment and neurological effects, including cognitive deficits. Here, we investigated the efficacy of tirzepatide (TIR), an antidiabetic agent that improve cognitive function in diabetic …

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Comparative Analysis of Pioglitazone and Tirzepatide on Body Weight, Glucose Levels, Neuroinflammation, and Oxidative Stress in Diabetic Rats

Ahmad Hamad Alhowail, Mohammed F. Aldawsari, Maha Abdulrahman Aldubayan

Introduction: Type 2 diabetes mellitus (T2DM) is a widespread metabolic illness that compromises cognitive function by inducing inflammation and oxidative damage. Diabetes mellitus is treated with many types of medications, including tirzepatide (TZP) and pioglitazone (PIO), which have also been shown to …

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Safety and efficacy of tocilizumab in COVID-19: A systematic evaluation of adverse effects and therapeutic outcomes

Othman AlOmeir, Ahmad Hamad Alhowail, Syed Imam Rabbani, Syed Mohammed Basheeruddin Asdaq et autres

BACKGROUND: While COVID-19 has transitioned from a pandemic to an endemic state, the management of its persistent complications continues to present substantial clinical challenges. Tocilizumab, an interleukin-6 receptor antagonist endorsed by the World Health Organization (WHO) for severe COVID-19 management, remains a …

sa, Afrique du Sud (code pays fourni par la source)

Cisplatin induces hippocampal neurotoxicity and cognitive impairment in rats through neuroinflammation, oxidative stress, and overexpression of glutamatergic receptors mRNA

Ahmad Hamad Alhowail

Chemotherapy-induced cognitive deficits are a prevalent adverse effect in patients with cancer undergoing chemotherapy. We investigated cisplatin-induced neurotoxicity by assessing neuroinflammation and expression of glutamate receptors. Two groups of eight-week-old rats (n = 10 per group) were used: control and cisplatin-treated. Cisplatin …

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Direct Thrombin Inhibitors Suppress Type 1 Diabetes Development through PI3K/p-AKT Pathway

Hussien M. Ali, Ahmad Hamad Alhowail, Maha Abdulrahman Aldubayan, Mohamed Sadek Abdel‐Bakky

BACKGROUND: Diabetes mellitus type-1 is an immunological disease associated with low insulin release and hyperglycemia due to beta cell loss. No clear studies show the relationship between the coagulation cascade activation and diabetes mellitus type-1 development. OBJECTIVE: The present work aimed to …

sa, Égypte (code pays fourni par la source)

Comparison of Bumetanide, Levetiracetam and Sodium Valproate Effects on Convulsions and Motor Coordination in Experimental Models

Mohammed Salem Alharbi, Hussein Mohammad Ali, Ahmad Hamad Alhowail, Bader Ahmad Algohane et autres

Background and Objective: Given the high prevalence of adverse effects with current antiepileptic drugs and limited understanding of their mechanisms, this study aimed to evaluate the anticonvulsant effects, neurotoxic profiles and mechanisms of Bumetanide, Levetiracetam and Valproate (VAL, in rodent epilepsy models). …

sa, Égypte (code pays fourni par la source)