Renelle Pointdujour‐Lim

Do Children With Epiblepharon And Tearing Require Eyelid Surgery To Alleviate Their Problem?

Renelle Pointdujour‐Lim, Roman Shinder

An epiblepharon is a congenital horizontal fold of skin near the margin of the lower eyelid caused by the abnormal insertion of muscle fibers, which causes the eyelashes to assume a vertical position ( Figure 44–1 ). The condition is usually bilateral, …

Clonal determinants of organotropism and survival in metastatic uveal melanoma

Bailey S.C.L. Jones, Patrick Demkowicz, Mitchelle Matesva, Renelle Pointdujour‐Lim et autres

Abstract Uveal melanoma (UM), the most common intraocular primary cancer in adults, demonstrates a unique proclivity for liver metastasis. To understand the molecular underpinnings of this organotropism, we analyzed the genomic features of liver and extrahepatic UM metastases, identifying distinct molecular signatures …

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43144 A Systematic Literature Review of Treatment Patterns and Outcomes Associated with Hedgehog Inhibitors in Periocular Basal Cell Carcinoma

Renelle Pointdujour‐Lim, Janet Lee, Nathaniel E. Smith, Nindhana Paranthaman et autres

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Determinants of overall survival in patients with metastatic uveal melanoma

Patrick Demkowicz, Renelle Pointdujour‐Lim, Sofia Miguez, Yesung Lee et autres

BACKGROUND: Despite improvements in the treatment of primary uveal melanoma (UM), patients with metastatic disease continue to exhibit poor survival. METHODS: A retrospective review of metastatic UM patients at Yale (initial cohort) and Memorial Sloan Kettering (validation cohort) was conducted. Cox proportional …

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Validation of the Prognostic Usefulness of the Gene Expression Profiling Test in Patients with Uveal Melanoma

Sofia Miguez, R. Lee, Alison Chan, Patrick Demkowicz et autres

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NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature

Rahul M. Dhodapkar, Jane Z. Spadaro, Jacob S. Heng, John H. Sinard et autres

PURPOSE: To present the clinical course of a patient with recurrent NK/T-cell lymphoma (NKTL) involving the orbit and to review the literature on patients with NKTL involving the orbit. METHODS: The PubMed database was searched for all cases of NKTL involving orbital, …

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Local recurrence of uveal melanoma and concomitant brain metastases associated with an activating telomerase promoter mutation seven years after secondary enucleation

Jacob S. Heng, Brittany Perzia, John H. Sinard, Renelle Pointdujour‐Lim

Purpose: To describe a case of local recurrence of uveal melanoma with concomitant brain metastases after secondary enucleation. Observations: A 73 year-old patient presented with dizziness and gait instability. MRI of the orbits and brain showed an anophthalmic socket with an orbital …

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Cemiplimab for Orbital Squamous Cell Carcinoma in 11 Cases

Benjamin Steren, Barbara Burtness, Aarti Bhatia, Hakan Demirci et autres

PURPOSE: To review the demographics, clinical features, and response of orbital squamous cell carcinoma treated with cemiplimab. METHODS: This is a retrospective multi-institutional series. Patient characteristics, drug dosing, duration, and response to treatment were evaluated. RESULTS: The study cohort consisted of 11 …

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Dacryocystitis in a patient with Samter's triad

Ahmad Abdel-Aty, Andrew Jin, R Peter Manes, Mohammad Shibly Khan et autres

Samter's triad, also known as aspirin-exacerbated respiratory disease, is characterized by nasal polyposis, bronchial asthma, and aspirin intolerance. Here, we present a case of a 36-year-old woman with a history of Samter's triad and recurrent dacryocystitis. After combined dacryocystorhinostomy and endoscopic sinus …

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TRAF7 Mutated Subgroups Differ in Sphenoid Wing Meningiomas with Hyperostosis

Lan Jin, Shaurey Vetsa, Sagar Vasandani, Arushii Nadar et autres

Introduction: Sphenoid wing meningiomas (SWMs) can involve the sphenoid bone to varying degrees. Our previous study found that the degree of bony involvement can predict genomic subgroups in SWMs such that tumors with bone invasion were nearly 30 times more likely to …

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Autoimmune retinopathy with associated anti-retinal antibodies as a potential immune-related adverse event associated with immunotherapy in patients with advanced cutaneous melanoma: case series and systematic review

Jacob S. Heng, Jenna May Kim, D Kyle Jones, Kathleen Stoessel et autres

OBJECTIVE: To demonstrate the spectrum of autoimmune retinopathy (AIR) associated with immunotherapy for advanced cutaneous melanoma. METHODS AND ANALYSIS: Retrospective chart review on patients with advanced cutaneous melanoma who developed AIR after initiating immunotherapy. Complete ophthalmic examination and relevant ancillary testing were …

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Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review

Ahmad Abdel-Aty, Wendy L. Linderman, Ninani Kombo, John H. Sinard et autres

Background: Uveal melanoma is the most common primary intraocular malignancy in adults, often resulting in painless vision loss. We report a case of necrotic uveal melanoma presenting with orbital inflammation mimicking orbital cellulitis and present a comprehensive review of the literature and …

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