Weiling Xu

Early post-infarct fibroblast activation protein-targeted PET/CT with 68Ga-FAPI-46 identifies STEMI patients with preserved LVEF at higher risk for adverse remodeling and cardiovascular events

Ling Liang, Lingyu Yu, Dan Ruan, Weiling Xu et autres

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SNAPIN Facilitates Progression of Hepatocellular Carcinoma by Hindering Ferroptosis Through KEAP1 Degradation Promotion

Weiling Xu, Zhen Li, Rongqing Li, Jin Chen et autres

Hepatocellular carcinoma (HCC) ranks among the most pervasive forms of cancer worldwide. In our study, we observed a notable overexpression of SNAPIN in human HCC tissues, which was linked closely to patient prognosis. Our experiments demonstrated that SNAPIN enhances the proliferative capacity …

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Mitochondrial arginase 2 regulates hematopoietic and cardiovascular adaptation to hypoxia

Weiling Xu, Kewal Asosingh, Allison J. Janocha, Evan Madden et autres

Physiological adaptation to hypoxia involves coordinated responses of the hematopoietic and cardiovascular systems to maintain tissue oxygenation. Arginine metabolism, via nitric oxide synthases and arginases, modulates both erythropoiesis and vascular tone. Arginase 2 ( Arg2 ), a mitochondrial enzyme, may regulate these …

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Clinical Outcome of Extramedullary Multiple Myeloma in the Era of Novel Agents: Insights From a Multicenter Study

Dong Liang, Yurong Yan, Qiaoli Wang, Shenrui Bai et autres

This study aimed to discuss the clinical outcomes of extramedullary multiple myeloma in the era of novel agents, based on the largest dataset regarding extramedullary multiple myeloma in China. This study included 597 patients without extramedullary disease (EMD) (non-EMD), 324 with extramedullary …

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Hypoxia Responses in Arginase-2 Deficient Mice Enhance Cardiovascular Health

Weiling Xu, Kewal Asosingh, Anna Janocha, Ethan Madden et autres

Abstract RATIONALE: Physiological responses to hypoxia involve adaptations in hematopoietic and cardiovascular systems that work together to ensure adequate oxygen delivery to tissues for energy production. The arginine/nitric oxide (NO) pathway regulates both systems through effects on erythropoiesis and vasodilation. In Tibetan …

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Medium Chain Triglycerides as Nutritional Regulators of Airway Inflammation via Arginase-2 Metabolism

Kewal Asosingh, Weiling Xu, Anny Mulya, Anna Janocha et autres

Abstract Rationale: Medium chain triglycerides (MCTs) have been shown to have anti-inflammatory effects in diabetes and support metabolic health, but mechanisms are unclear. Arginase 2 (Arg2) is a mitochondrial protein that acts as a metabolic regulator of inflammation and metabolism in asthma. …

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Metabolic Adaptations to High-altitude Hypoxia in Two Ethiopian Populations

Anna Janocha, Anny Mulya, Michael Novotny, Weiling Xu et autres

Abstract Rationale: Chronic exposure to high-altitude hypoxia may elicit mitochondrial and metabolic responses to reduce the oxygen cost of energy production and decrease reactive oxygen species production. Two East African high-altitude populations have adapted physiologically to high altitude differently, the Amhara through …

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Clinical outcome of ≥2% circulating tumor cells in newly diagnosed multiple myeloma: insights from a multicenter study

Dong Liang, Yurong Yan, Shenrui Bai, Weiling Xu et autres

PURPOSE: Previous studies have shown that ≥2% circulating tumor cells (CTCs) in multiple myeloma are associated with a prognosis similar to primary plasma cell leukemia. This study aims to examine this ultra-high-risk patient subset and evaluate their clinical outcomes in a real-world …

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Author response for "Clinical Outcome of Extramedullary Multiple Myeloma in the Era of Novel Agents: Insights From a Multicenter Study"

Dong Liang, Yurong Yan, Qiaoli Wang, Shenrui Bai et autres

Comparison of 2D and 3D radiomics features with conventional features based on contrast-enhanced CT images for preoperative prediction the risk of thymic epithelial tumors

Yu-Hang Yuan, Hui Zhang, Weiling Xu, Dong Dong et autres

BACKGROUND: This study aimed to develop and validate 2-Dimensional (2D) and 3-Dimensional (3D) radiomics signatures based on contrast-enhanced computed tomography (CECT) images for preoperative prediction of the thymic epithelial tumors (TETs) risk and compare the predictive performance with conventional CT features. PATIENTS …

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Hypoxia responses in arginase 2 deficient mice enhance cardiovascular health

Weiling Xu, Kewal Asosingh, Allison J. Janocha, Evan Madden et autres

Abstract RATIONALE Physiological responses to hypoxia involve adaptations in the hematopoietic and cardiovascular systems, which work together to ensure adequate oxygen delivery to tissues for energy production. The arginine/nitric oxide (NO) pathway regulates both systems through its effects on erythropoiesis and vasodilation. …

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The impact of high-risk cytogenetic abnormalities in extramedullary multiple myeloma in the era of novel agents: insights from a multicenter study

Dong Liang, Yurong Yan, Shenrui Bai, Weiling Xu et autres

PURPOSE: This study aimed to examine the impact of high-risk cytogenetic abnormalities (HRA) on the survival outcomes of multiple myeloma patients with extramedullary disease (EMD) in the era of novel agents, utilizing the largest dataset of extramedullary multiple myeloma patients in China. …

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