Fabio Bucchieri

Where Tradition Meets Innovation: Integrating Historical Collections, Cadaveric Dissection, and Digital Technologies in Anatomy Education

Giuseppa D’Amico, M Di Marco, Giuseppe Vergilio, Francesca Monachino et autres

Backgrond/Objectives: Human anatomy education has traditionally relied on cadaveric dissection as the reference standard for acquiring anatomical knowledge. However, decreasing availability of donated bodies, curricular changes, and rapid technological advances have encouraged the progressive integration of complementary educational resources, including historical anatomical …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Antonella Marino, Gergely Orbán, Massimo Pierucci, Giancarlo Di Gennaro et autres

Hsp60 is widely distributed in the brain, and its alteration has been involved in different neurological disorders. Epilepsy is considered one of the most common neurological disorders and typically involves the hippocampal formation. Compelling evidence describes a role of mitochondria, oxidative stress …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Fabio Bucchieri, Francesco Cappello, Sabrina David, Antonio Noto et autres

The link between cigarette smoke (CS) and lung inflammation is quite strong, however relatively little is still known on the effects of CS on human bronchial epithelial cells survival during asthma. In this study we focused our attention on the apoptotic effects …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Antonella Marino, M Del Rizzo, Roberto Citarrella, Francesca Rappa et autres

Hsp60 is, typically, a mitochondrial protein, but it also occurs in the cytosol, vesicles, and plasma membrane, and in the intercellular space and biological fluids, e.g., blood. Changes in the levels and distribution of Hsp60 are linked to several pathologies, including cancer …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Francesco Cappello, Claudia Campanella, Fabio Bucchieri, Anna Maria Merendino et autres

Cancer cells have means to influence other cells in their vicinity and distant, and in this signal-delivering mechanisms the chaperonin Hsp60 plays a role, which is currently being recognized as potentially crucial for the growth and dissemination of at least certain types …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Francesco Cappello, Antonino Di Stefano, Gaetano Caramori, Claudia Campanella et autres

Inflammation is a major component of chronic obstructive pulmonary disease (COPD) and its cause and mechanisms are still incompletely understood. For example, the role of heat shock proteins (Hsps), many of which are molecular chaperones, has not been explored in detail in …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Fabio Bucchieri, Francesco Cappello, Alberto Fucarino, Alessandro Pitruzzella et autres

An innovative 3D model of the human bronchial mucosa, a result of a long- term collaboration with Prof. Davies from the University of Southampton, UK, will be used to study, on board the International Space Station (ISS), the chang- es occurring in …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Claudia Campanella D’Anneo, Antonella Marino, Celeste Caruso Bavisotto, Rosario Barone et autres

The chaperonin Hsp60 has multiple functions, among which that of supporting the growth of some type of tumours. HDACi (histone-deacetylase inhibitors) are drugs that regulate gene expression via modulation of epigenetic mechanisms, and induce tumor-cell death. Here, we show that in the …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Fabio Bucchieri, Alberto Fucarino, Salvatore Montesanto, Alessandro Pitruzzella et autres

The recent progress in the biomaterials field and the need for novel 3D cell culture models has led us to develop a new model, the 3D mucosal outgrowth, with advanced characteristics: the simultaneous presence of two differentiated cytotypes (a polarized epithelium above …

Toxic effects of biodegradable polylactic acid nanoplastics on developing zebrafish (Danio rerio)

Federica Scalia, Fabiano Capparucci, Maria Denise Amico, Marianna Marino et autres

Plastic contamination represents a significant threat to the environment with potential health risks for all species. Recently, bio-based plastics have been introduced as a green alternative to fossil-based ones. However, bioplastic degradation products present potentially harmful effects comparable to the fossil-based ones. …

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Ex-vivo three-dimensional model of T2-asthma: effects of the monoclonal antibody against interleukin-4 receptor α

Alida Benfante, Giorgia Intili, Stefano Burgio, Domenico Michele Modica et autres

Introduction: Severe asthma treatment is hindered by the lack of reliable cellular or animal models that allow in vitro pharmacological testing and evaluation of tissue responses. Aims: To develop a novel ex vivo three-dimensional (3D) co-culture model of type 2 (T2) asthma …

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Exploring Methacrylated Gellan Gum 3D Bioprinted Patches Loaded with Tannic Acid or L-Ascorbic Acid as Potential Platform for Wound Dressing Application

Federica Scalia, Alessandra Maria Vitale, Domiziana Picone, Noemi De Cesare et autres

To improve wound healing, advanced biofabrication techniques are proposed here to develop customized wound patches to release bioactive agents targeting cell function in a controlled manner. Three-dimensional (3D) bioprinted “smart” patches, based on methacrylated gellan gum (GGMA), loaded with tannic acid (TA) …

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