John H. Molinski

Rapid, Tunable, and Scalable Patterning of Plasmonic Films for Biosensing Applications

John H. Molinski, Junhu Zhou, Timothy J. Palinski, John X. J. Zhang

High Resolution Image Download MS PowerPoint Slide Large-scale and rapid fabrication of tailorable, uniform, and patterned plasmonic surfaces is of significant interest within the biosensing application space. Prior attempts have primarily investigated solution and thin film-based methods, which often incorporate complex synthesis …

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Laser‐Patterning of Micromagnets for Immuno‐Magnetophoretic Exosome Capture (Small Methods 12/2024)

John H. Molinski, Siddhant Parwal, John X. J. Zhang

Laser-Patterning In article number 2400388, Zhang and co-workers introduce a laser-based method for fabricating and patterning micromagnets. Finite element analysis modeling was used to optimize micromagnet unit cells for magnetophoretic capture, which were incorporated into both open-air microwells and enclosed microfluidic systems. …

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Laser‐Patterning of Micromagnets for Immuno‐Magnetophoretic Exosome Capture

John H. Molinski, Siddhant Parwal, John X. J. Zhang

Abstract Efficient isolation and patterning of biomolecules is a vital step within sample preparation for biomolecular analysis, with numerous diagnostic and therapeutic applications. For exosomes, nanoscale lipid‐bound biomolecules, efficient isolation is challenging due to their minute size and resultant behavior within biofluids. …

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Laser-patterning of micromagnets for magnetophoretic biomolecule capture

John H. Molinski, Siddhant Parwal, John X. J. Zhang

Abstract Efficient and controlled isolation and patterning of biomolecules is a vital process step within sample preparation for biomolecular analysis, and within numerous diagnostic and therapeutic applications. For exosomes, nanoscale (30–150 nm) lipid bound biomolecules, efficient isolation is challenging, due in part …

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Laser-Manufactured Magnetic Microchips for Exosome Isolation and Patterning

John H. Molinski, Siddhant Parwal, John X. J. Zhang

We report the development of a laser-based micromagnet patterning process and magnetic microchip architecture enabled by this process which facilitates isolation of exosomes via pattering of magnetic composite. The laser-based manufacturing process supports raw material to device manufacturing inin2), without lithographic processing. …

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List of contributors

Kimberly H. Allison, Megan Allyse, Matthew B. Smolkin, Michael J. Bartel et autres

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Nanotechnology for molecular diagnostics

Amogha Tadimety, John H. Molinski, John X. J. Zhang

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Plasmonic nanosensors for point-of-care biomarker detection

Congran Jin, Ziqian Wu, John H. Molinski, Junhu Zhou et autres

Advancement of materials along with their fascinating properties play increasingly important role in facilitating the rapid progress in medicine. An excellent example is the recent development of biosensors based on nanomaterials that induce surface plasmon effect for screening biomarkers of various diseases …

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Plasmonic Nanoparticle Conjugation for Nucleic Acid Biosensing

Amogha Tadimety, Yichen Zhang, John H. Molinski, Timothy J. Palinski et autres

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Rational design of on-chip gold plasmonic nanoparticles towards ctDNA screening

Amogha Tadimety, Ziqian Wu, John H. Molinski, Russell Beckerman et autres

This paper demonstrates the design, synthesis, simulation, and testing of three distinct geometries of plasmonic gold nanoparticles for on-chip DNA screening towards liquid biopsy. By employing a seed-mediated growth method, we have synthesized gold nanospheres, nanorods, and nanobipyramids. In parallel, we developed …

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Shape Effects of Plasmonic Gold Nanoparticles for Circulating Tumor DNA Screening

Amogha Tadimety, Ziqian Wu, John H. Molinski, Russell Beckerman et autres

We design, simulate, and experimentally characterize the effects of gold nanoparticle geometry on plasmonic nanosensing performance. Gold nanorods, nanospheres, and nanobipyramids of consistent shape were synthesized using a seed-mediated growth method and characterized using electron microscopy. The plasmonic resonance features and sensitivity …

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Scalable Signature-Based Molecular Diagnostics Through On-chip Biomarker Profiling Coupled with Machine Learning

John H. Molinski, Amogha Tadimety, Alison Burklund, John X. J. Zhang

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