Maria Bercea

Highlighting the Anti-Inflammatory Activity of Topical Gels Loaded with Meloxicam: The Role of Different Excipients and Absorption Promoters

Ioana‐Alexandra Plugariu, Luiza Mădălina Grădinaru, Irina Popescu, Maria Bercea

Thermosensitive polyurethane (PU) hydrogels were prepared and loaded with meloxicam (MX), a nonsteroidal anti-inflammatory drug (NSAID). The role of different excipients, i.e., eucalyptus essential oil as well as poly(vinylpyrrolidone), poly(ethylene glycol) and their mixture, was highlighted. The sol-gel transition induced by temperature …

New perspectives on the ozonated high-oleic sunflower oil physico-chemical behaviour

Anca Roxana Petrovici, Vasile Paraschiv, Alina Nicolescu, Mirela-Fernanda Zaltariov et autres

Despite high-oleic sunflower oil (SFO) having strong antioxidant properties, there are very few studies regarding its physico-chemical characterization. In this study, SFO obtained through cold pressing, without prior chemical treatment, was subjected to an ozonation process. Simultaneously, a water-SFO emulsion (1:9 ratio) …

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Smart supramolecular hydrogels as a potential platform for wound dressings: Harnessing thiamine to boost neomycin efficacy

Alexandra Lupu, Luiza Mădălina Grădinaru, Maria Bercea, Mihaela Avădanei et autres

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3D printed patches based on modified hyaluronic acid with antibacterial and anti-inflamatory properties

Loredana E. Niţă, Isabella Nacu, Alina Gabriela Rusu, Alina Ghilan et autres

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Chitosan based hydrogels as temporary implants for breast cancer postsurgical treatment and site-infections prophylaxis

Daniela Ailincai, Maria Bercea, Irina Roșca, Andreea-Isabela Sandu et autres

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VISCOSITY OF HYDROXYPROPYL CELLULOSE SOLUTIONS IN THE PRESENCE OF POLY(N-VINYLPYRROLIDONE)

Maria Bercea, Alexandra Lupu, Ioana‐Alexandra Plugariu, Luiza Mădălina Grădinaru et autres

The paper reports viscosity data for aqueous solutions of hydroxypropyl cellulose (HPC) in the presence of poly(N-vinylpyrrolidone) (PVP) in dilute, semidilute and concentrated regimes. The two polymers are miscible over the entire range of composition. In dilute solution, mixed isolated coils with …

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Water-soluble hydroxypropyl curdlan derivatives with thermosensitive properties

Gabriela Liliana Ailiesei, Irina Popescu, Mihaela Avădanei, Maria Bercea et autres

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Effect of chitosan on 3D printed scaffolds with gelatin–hyaluronic acid, hydroxyapatite and magnetic nanoparticles for bone tissues defects repair

Iustina Apăvăloaiei, Isabella Nacu, Florina-Daniela Cojocaru, Vera Bălan et autres

Bone is a dynamic and vascularized tissue, with self-healing abilities, efficient in treating minor defects. Bone tissue engineering has focused on materials used to reconstruct large orthopedics defects and 3D (bio)printing is a revolutionary technology able to design well-defined geometries. The paper …

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New Gel Approaches for the Transdermal Delivery of Meloxicam

Maria Bercea, Luiza Mădălina Grădinaru

Meloxicam is a promising non-steroidal anti-inflammatory drug (NSAID) for acute and chronic pain prevention and treatment. Due to its poor water solubility, the clinical use of meloxicam is limited. In addition, for transdermal applications, the impermeability of the skin makes it difficult …

Targeting Injectable Hydrogels: The Role of Diphenylalanine Peptide Derivative in the Gelation Dynamics of Pluronic® F127

Vasile Robert Grădinaru, Maria Bercea, Luiza Mădălina Grădinaru, Alexandra Lupu et autres

The fluorenyl methyl oxycarbonyl phenylalanyl-phenylalanine methyl ester (Fmoc-Phe-Phe-Ome) was synthetized using the liquid phase synthesis strategy. This derivative was separated by hydrophobic interaction chromatography, its purity was analyzed by RP-HPLC and it was characterized by mass spectrometry. This extremely hydrophobic peptide conjugate …

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Antimicrobial chitosan-based hydrogels: A novel approach to obtain sanitizers

Daniela Ailincai, Maria Bercea, Irina Roșca, Ioana Sandu et autres

The study presents novel hydrogels obtained by crosslinking chitosan with both furfural and glutaraldehyde via dynamic imine bonds. Scanning electron microscopy confirmed the formation of porous networks with a mean diameter of the pores between 15 and 35 μm, while the supramolecular …

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Water-Soluble Hydroxypropyl Curdlan Derivatives with Thermosensitive Properties

Gabriela Liliana Ailiesei, Irina Popescu, Mihaela Avădanei, Maria Bercea et autres

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