Gyanu Lamichhane

Carbon starvation of Mycobacterium abscessus induces a non-replicating state with extensive proteomic remodeling

Kaylyn L. Devlin, Gyanu Lamichhane, William C Nelson, Vivian Stephanie Lin et autres

ABSTRACT Mycobacterium abscessus ( Mab ) is an opportunistic pathogen that can cause chronic, debilitating lung disease. Mab is intrinsically resistant to most antibiotics, making Mab infections challenging to manage and frequently incurable. During infection, Mab adapts to survive various stresses, including …

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Expanding the scope of Mycobacterium abscessus reference strains to improve pulmonary disease modeling

Ruth A. Howe, Chavis Tabor, Chandra M. Panthi, Guoqing Cheng et autres

ABSTRACT Mycobacterium abscessus ( Mab ) pulmonary disease is an emerging clinical challenge, particularly among individuals with immunosuppression or underlying structural lung conditions. There are currently no FDA-approved therapies for Mab disease. Existing treatment strategies using repurposed drugs are prolonged, complex, and …

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Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus

Kaylyn L. Devlin, Emily Hutchinson, Damon T. Leach, Leo J. Gorham et autres

High Resolution Image Download MS PowerPoint Slide The pathogen Mycobacterium abscessus ( Mab ) can cause severe and difficult-to-treat chronic lung infections. Despite the rising incidence and clinical concern of Mab infections, treatment options are limited and often ineffective. Treatment is complicated …

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Chemoproteomic Elucidation of β‑Lactam Drug Targets in Mycobacterium abscessus

Kaylyn L. Devlin, Emily Hutchinson, Damon T. Leach, Leo J. Gorham et autres

CCDC 2449428: Experimental Crystal Structure Determination

Kelsey R. Latterell, Evan Keil, Benjamin R. Kraemer, Joe B. Huisken et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2449427: Experimental Crystal Structure Determination

Kelsey R. Latterell, Evan Keil, Benjamin R. Kraemer, Joe B. Huisken et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

P-1404. Optimizing Preclinical Models and Therapeutic Combinations for Nontuberculous Mycobacterial Lung Disease

Ruth A. Howe, Chandra M. Panthi, Binayak Rimal, Gyanu Lamichhane

Abstract Background Pulmonary disease caused by the nontuberculous mycobacteria (NTMs) Mycobacteroides abscessus (Mab) and M. avium (MAC) is a rising clinical concern, with increased incidence above expectation from advances in detection. Prolonged, multimodal antibiotic treatment that often relies on a parenteral agent …

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Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse

Ruth A. Howe, Binayak Rimal, Jay Khandelwal, Chandra M. Panthi et autres

BACKGROUND: The incidence of nontuberculous mycobacterial (NTM) infections has been rising and now exceeds tuberculosis in several countries. Mycobacterium avium is the most common NTM cause of chronic lung disease. Current guidelines recommend simultaneous administration of three or more antibiotics, modeled after …

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Synthesis and evaluation of novel oxanthrene scaffold-derived oxazolidinone antibiotics with potent antitubercular activity and low cellular toxicity

Kelsey R. Latterell, Joe B. Huisken, Noah M. Daniels, Amit Kumar Kaushik et autres

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Efficacies of sequenced monotherapies of Mycobacterium avium lung infection in mouse

Ruth A. Howe, Binayak Rimal, Jay Khandelwal, Chandra M. Panthi et autres

ABSTRACT Background The incidence of non-tuberculous mycobacterial (NTM) infections has been rising and now exceeds tuberculosis in several countries. Among NTMs, Mycobacterium avium is the most common cause of chronic lung disease. Current guidelines recommend simultaneous administration of three or more antibiotics, …

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Comprehensive Identification of β-Lactam Antibiotic Polypharmacology in Mycobacterium tuberculosis

Kaylyn L. Devlin, Emily Hutchinson, Hailey N. Dearing, Samantha R. Levine et autres

Infections with Mycobacterium tuberculosis ( Mtb ) cause tuberculosis (TB), which requires at least 6 months of treatment with multiple antibiotics. There is emergent interest in using β-lactam antibiotics to improve treatment outcomes for patients. These drugs target cell wall biosynthesis, but …

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Combinations comprising dual β-lactams and a β-lactamase inhibitor achieve optimal synergistic inhibition of Mycobacterium abscessus growth

Binayak Rimal, Yi Xie, Chandra M. Panthi, Kaylyn L. Devlin et autres

ABSTRACT The historical model, which posits that β-lactams inhibit bacterial growth while β-lactamase inhibitors (BLIs) merely protect β-lactams from enzymatic degradation, fails to fully explain their activity against Mycobacterium abscessus ( Mab ). This study demonstrates that synergistic effects extend beyond the …

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