Carine Claeys

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

Raffael Nachbagauer, Jodi Feser, Abdollah Naficy, David I. Bernstein et autres

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Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

Raffael Nachbagauer, Bruno Salaun, Daniel Stadlbauer, Mohammad Amin Behzadi et autres

Licensed influenza virus vaccines target the head domain of the hemagglutinin (HA) glycoprotein which undergoes constant antigenic drift. The highly conserved HA stalk domain is an attractive target to increase immunologic breadth required for universal influenza virus vaccines. We tested the hypothesis …

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Quadrivalent Influenza Vaccine Prevents Illness and Reduces Healthcare Utilization Across Diverse Geographic Regions During Five Influenza Seasons

Ghassan Dbaibo, Arshad Amanullah, Carine Claeys, Allen Izu et autres

BACKGROUND: We evaluated an inactivated quadrivalent influenza vaccine (IIV4) in children 6-35 months of age in a phase III, observer-blind trial. METHODS: The aim of this analysis was to estimate vaccine efficacy (VE) in preventing laboratory-confirmed influenza in each of 5 independent …

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Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

David I. Bernstein, Jeffrey T. Guptill, Abdollah Naficy, Raffael Nachbagauer et autres

BACKGROUND: Influenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the circulating strains. However, antigenic drift can cause considerable mismatches between vaccine and circulating strains, substantially reducing vaccine effectiveness. Moreover, current seasonal …

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Clinical Presentation of Influenza in Children 6 to 35 Months of Age

Jasur Danier, Luis Rivera, Carine Claeys, Ghassan Dbaibo et autres

BACKGROUND: In an exploratory analysis of an inactivated quadrivalent influenza vaccine (IIV4) trial in children 6-35 months without risk factors for influenza, we evaluated clinical presentation of influenza illness and vaccine impact on health outcomes. METHODS: This phase III trial was conducted …

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Anamnestic Immune Response and Safety of an Inactivated Quadrivalent Influenza Vaccine in Primed Versus Vaccine-Naïve Children

Carine Claeys, Vijayalakshmi Chandrasekaran, José García-Sicilia, Roman Prymula et autres

BACKGROUND: It has not yet been demonstrated whether 2 doses of inactivated quadrivalent influenza vaccine (IIV4) prime a booster response in infants. We evaluated the anamnestic immune response to an IIV4 in children 17-48 months of age. METHODS: Children were randomized to …

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Assessment of an optimized manufacturing process for inactivated quadrivalent influenza vaccine: a phase III, randomized, double-blind, safety and immunogenicity study in children and adults

Carine Claeys, Mamadou Dramé, José García-Sicilia, Khalequ Zaman et autres

BACKGROUND: GSK has modified the licensed monovalent bulk manufacturing process for its split-virion inactivated quadrivalent influenza vaccine (IIV4) to harmonize the process among different strains, resulting in an increased number of finished vaccine doses, while compensating for the change from inactivated trivalent …

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Prevention of vaccine-matched and mismatched influenza in children aged 6–35 months: a multinational randomised trial across five influenza seasons

Carine Claeys, Khalequ Zaman, Ghassan Dbaibo, Ping Li et autres

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Additional file 1: of Assessment of an optimized manufacturing process for inactivated quadrivalent influenza vaccine: a phase III, randomized, double-blind, safety and immunogenicity study in children and adults

Carine Claeys, Mamadou Dramé, José García-Sicilia, Khalequ Zaman et autres

Solicited oculorespiratory syndrome–like symptoms within the 3-day post vaccination period in infants (6–35 months), children (3–17 years), and adults (18–49 years) (total vaccinated cohort). (PDF 378 kb)

Immunogenicity and Safety of an Adjuvanted Herpes Zoster Subunit Vaccine Coadministered With Seasonal Influenza Vaccine in Adults Aged 50 Years or Older

Tino F. Schwarz, Naresh Aggarwal, Beate Moeckesch, Isabelle Schenkenberger et autres

Background: The immunogenicity and safety of an adjuvanted herpes zoster subunit (HZ/su) vaccine when coadministered with a quadrivalent seasonal inactivated influenza vaccine (IIV4) was investigated in a phase 3, open-label, randomized clinical trial in adults aged ≥50 years. Methods: Subjects were randomized …

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A review of the value of quadrivalent influenza vaccines and their potential contribution to influenza control

Riju Ray, Gaël Dos Santos, Philip O. Buck, Carine Claeys et autres

The contribution of influenza B to the seasonal influenza burden varies from year-to-year. Although 2 antigenically distinct influenza B virus lineages have co-circulated since 2001, trivalent influenza vaccines (TIVs) contain antigens from only one influenza B virus. B-mismatch or co-circulation of both …

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INACTIVATED QUADRIVALENT INFLUENZA VACCINE PREVENTS DISEASE DUE TO MATCHED AND MISMATCHED STRAINS: A RANDOMISED TRIAL IN CHILDREN AGED 6–35 MONTHS DURING 2011–2014

Carine Claeys