Zhong‐Zhen Zhou

Discovery of Novel Natural Product-Based PDE4 Inhibitors for Ischemic Stroke Treatment without Emetogenicity at Ultra-High Doses

Chuang Xia, Mingjia Yu, Yujie Ni, Shanfang Fang et autres

Phosphodiesterase-4 (PDE4) inhibitors show potential for treating ischemic stroke, but are often constrained by emesis or low blood-brain barrier (BBB) permeability. To overcome these challenges, this paper developed novel PDE4 inhibitors via AI-driven structural evolution of natural antistroke products and identified the …

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Discovery of novel pyrrolopyrimidine-based PDE7 inhibitors against alcoholic liver injury

Jiaxi Huang, Chuang Xia, L. Li, Huichang Bi et autres

A novel PDE4 inhibitor ZX21011 alleviates neuronal apoptosis by decreasing GSK3β-mediated Drp1 Ser616 phosphorylation in cerebral ischemia reperfusion

Huizhen Wen, Xingxing Tu, Fulan Luo, Chunyuan Zeng et autres

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Discovery of novel N2-indazole derivatives as phosphodiesterase 4 inhibitors for the treatment of inflammatory bowel disease

Lei Zheng, Kun Chen, Yifan Xie, Jiaxi Huang et autres

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Discovery of 7-alkoxybenzofurans as PDE4 inhibitors with hepatoprotective activity in D-GalN/LPS-induced hepatic sepsis

Chuang Xia, Huizhen Wen, Lei Zheng, Yujie Ni et autres

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Discovery of 7-Alkoxybenzofurans as Pde4 Inhibitors with Hepatoprotective Activity in D-Galn/Lps-Induced Hepatic Sepsis

Chuang Xia, Huizhen Wen, Lei Zheng, Yujie Ni et autres

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Discovery of 4-Ethoxy-6-chloro-5-azaindazoles as Novel PDE4 Inhibitors for the Treatment of Alcohol Use Disorder and Alcoholic Liver Diseases

Lei Zheng, Zulihuma Aimaiti, Lu Long, Chuang Xia et autres

Alcohol use disorder (AUD) results in numerous disabilities and approximately 3 million deaths annually, caused mainly by alcoholic liver disease (ALD). Phosphodiesterase IV (PDE4) has emerged as an attractive molecular target for a new treatment for AUD and ALD. In this study, …

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An overview of phosphodiesterase 9 inhibitors: Insights from skeletal structure, pharmacophores, and therapeutic potential

Lei Zheng, Zhong‐Zhen Zhou

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Advances in the development of phosphodiesterase 7 inhibitors

Jiaxi Huang, Bolin Zhu, Jiangping Xu, Zhong‐Zhen Zhou

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Cascade C–C bond cleavage/reformation and cycloaddition for the synthesis of 4-acyl 1,2,3-triazoles from β-alkyl nitroalkenes and organic azides

Lei Zheng, Tao Yi, Ruilin Fang, Zhong‐Zhen Zhou et autres

A copper( ii )-catalyzed synthesis of 4-acyl-1,2,3-triazoles from β-alkyl-nitroalkenes and organic azides via a cascade C–C bond cleavage/reformation and cycloaddition reaction sequence.

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Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors

XiaoYang Li, Huanxian Wu, Kai-Wen Feng, Jiahuan Xu et autres

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Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease

Jie Liu, Lu Liu, Lei Zheng, Kai-Wen Feng et autres

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