R.Ya. Dutka

Dynamics of antioxidant protection indicators under the influence of graded exercise against the background of changes in cortisol levels in patients with arterial hypertension

I.S. Dronyk, R.Ya. Dutka, N.V. Chmyr, R.S. Pshyk et autres

Background. Arterial hypertension (AH) remains a lea­ding risk factor for the development of cardiovascular complications. Chronic stress and alterations in neuroendocrine regulation, particularly in the activity of the hypothalamic-pituitary-adrenal axis, play a key role in the pathogenesis of AH. Physical exertion is …

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THE ROLE OF THE GUT MICROBIOME IN THE RISK OF CARDIOVASCULAR DISEASE: FROM DYSBIOSIS TO ATHEROTHROMBOSIS

N.V. Chmyr, Andriy Bazylevych, L. Kobak, Yu.O. Svitlyk et autres

This review article analyses current understanding of the role of the gut microbiome in the development of cardiovascular diseases. The gut microbiome is considered a complex environmental system involved in the regulation of metabolic, immune and inflammatory pathways that are directly relevant …

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Comparative characteristics of lipid spectrum in patients with cardiovascular-kidney-metabolic syndrome depending on its stage and type 2 diabetes mellitus

N.V. Chmyr, R.Ya. Dutka, I.S. Dronyk, K. Abrahamovych et autres

Background. Cardiovascular-kidney-metabolic syndrome (CKMS) is a multifactorial pathological condition, the pathogenesis of which combines mutually reinforcing mechanisms of cardiovascular, renal and metabolic disorders that significantly increases the risk of progression of coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) and chronic …

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The risk of coronary artery disease in patients with type 2 diabetes mellitus and metabolic syndrome

N.V. Chmyr, R.Ya. Dutka, H.V. Svitlyk, N.M. Gromnatska et autres

Background. The relevance of this work is due to the growing need for a personalized approach to the management of patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) that arose on the background of metabolic syndrome (MS) and …

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PECULIARITIES OF CARBOHYDRATE METABOLISM INDICATORS, THE FUNCTIONAL STATE OF THE THYROID GLAND IN THE COURSE TREATMENT WITH TELMISARTAN AS PART OF THE COMPLEX THERAPY OF PATIENTS WITH CORONARY ARTERY DISEASE, TYPE 2 DIABETES MELLITUS ON THE BASIS OF METAB

Nataliya Chmyr, R.Ya. Dutka, H.V. Svitlyk, I.S. Dronyk et autres

Aim. Is to study the characteristics of carbohydrate metabolism indicators, the functional state of the thyroid gland in the course treatment with Telmisartan as a part of the complex therapy of patients with Coronary Artery Disease, type 2 Diabetes Mellitus on the …

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Pathogenetic and clinical rationale for syntropic pathology based on metabolic syndrome, coronary heart disease and type 2 diabetes mellitus

N.V. Chmyr, R.Ya. Dutka, I.S. Dronyk, Kh.Ya. Abrahamovych et autres

Topicality. Metabolic syndrome (MS), type 2 diabetes mellitus (DM), and coronary artery disease (CAD) are global health problems. Cardiovascular diseases (CVD) are found in 34.8% of people with type 2 diabetes and MS. According to a meta-analysis of 102 prospective studies, it …

IMPACT OF VITAMIN E AND SELENIUM INTAKE ON ANTIOXIDANT PROTECTION INDICATORS DURING PHYSICAL EXERTION IN INDIVIDUALS WITH HYPERTENSION

I.S. Dronyk, R.Ya. Dutka, Nathalia Chmyr, R.S. Pshyk et autres

Hypertension remains one of the main problems in modern medicine since it is a pathogenetic factor leading to a large number of cardiovascular diseases and premature death. The aim of the study is to measure and compare the levels of sulfhydryl groups …

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Changes in the cortisol level under the influence of physical exertion in patients with hypertension and in practically healthy individuals

I.S. Dronyk, R.Ya. Dutka, N.V. Chmyr, R.S. Pshyk et autres

Background. Today, there are difficulties with the prevention and diagnosis of early stages of hypertension, especially in active and able-bodied young people. Among the factors that potentiate an increase in blood pressure, one of the components is chronic stress, which a person …

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Correction of the antioxidant system in people with arterial hypertension against the background of dosed physical activity

I.S. Dronyk, R.Ya. Dutka, R.S. Pshyk, N.V. Chmyr et autres

This study aims to determine and compare the content of diene conjugates, plasma malondialdehyde and its active form, plasma vitamin E and blood selenium in patients with stage II hypertension before and after dosed exercise before and after taking vitamin E and …

Study of alpha defensin in coronary artery disease and type 2 diabetes mellitus on the background of metabolic syndrome

N.V. Chmyr, R.Ya. Dutka, Kh.Ya. Abrahamovych, Y. M. Fedechko et autres

Background. The prevalence of metabolic syndrome (MS), a cluster of risk factors for type 2 diabetes mellitus (DM) and coronary artery disease (CAD), is increasing annually. MS is associated with an almost 2-fold increase in the risk of cardiovascular complications and 1.5-fold …

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Діагностична та прогностична цінність гормональних показників, ліпідного спектра таультрасонографічних параметрів міокарда приметаболічному синдромі, ускладненому хронічною ішемічною хворобою серця і цукровим діабетом 2-го типу

R.Ya. Dutka, N.V. Chmyr, Z.R. Leontieva, Y.M. Fedechko

Актуальність. Синтропічна патологія, зумовлена поєднанням метаболічних і гормональних змін, призводить до розвитку ускладнень серцево-судинної патології як безпосередньої причини смертності та зменшення тривалості чи якості життя населення. Щодо ролі гормонів при даній комплексній патології слід зауважити, що не повністю доведена їх патогенетична і …

LESIONS OF RESPIRATORY SYSTEM IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS:

U. Abrahamovych, О. Аbrahamovych, R.Ya. Dutka, M. Farmaha et autres

Introduction. The respiratory system lesions in patients with systemic lupus erythematosus have not been properly addressed by both clinicians and scientists yet, since the progression of these lesions is often asymptomatic. Objective. To identify and determine the nature and prevalence of respiratory …

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