Sen Yan

Gut microbiota and neurotransmitter network underlies EHDPP-induced neurotoxicity in zebrafish

Jin Yan, Yuning Zhang, Ni Anyu, Yu Zukang et autres

cn (code pays fourni par la source)

Restoration of Gut Microbiota Vertical Transmission by Bifidobacterium Mitigates Pollutant-Induced Intergenerational Obesity

Sinuo Tian, Zhao Fang, Zhiyuan Meng, Wei Sun et autres

Abstract Mass production and widespread distribution of environmental pollutants enhance human susceptibility to disease, which may be related to gut microbial communities. However, the link between the transgenerational toxic effects of environmental pollutants and animal gut microbial communities remains obscure. Here, we …

cn (code pays fourni par la source)

A durably colonizing engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Qixiang Zhao, Yong Ding, Sen Yan, Haohan Ma et autres

ABSTRACT Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic molecules, but their efficacy is limited by inefficient colonisation, safety concerns and the need for repeated administration or auxiliary delivery systems. Objective To develop a safety-optimised native …

cn (code pays fourni par la source)

Subcutaneous transplantation of mesenchymal stem cell spheroids ameliorates cognitive deficits in Alzheimer's disease

Lei Sha, Min Wu, Si Sun, Y. Xie et autres

BackgroundMesenchymal stem cell (MSC)-based therapy has emerged as a promising alternative treatment for Alzheimer's disease (AD) but is limited by low cell survival rates and complex handling.ObjectiveThe present study explored the therapeutic potential of subcutaneous transplantation of MSC spheroids in a mouse …

cn (code pays fourni par la source)

Time-wavelength multiplexed photonic neural network accelerator for distributed acoustic sensing systems

Fuhao Yu, Kangjian Di, Wenjun Chen, Sen Yan et autres

Distributed acoustic sensors (DASs) can effectively monitor acoustic fields along sensing fibers with high sensitivity and high response speed. However, their data processing is limited by the performance of electronic signal processing, hindering real-time applications. The time-wavelength multiplexed photonic neural network accelerator …

cn (code pays fourni par la source)

Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α

Jialin Xia, Hong Chen, Xiaoxiao Wang, Weixuan Chen et autres

Non-alcoholic steatohepatitis (NASH) is a severe type of the non-alcoholic fatty liver disease (NAFLD). NASH is a growing global health concern due to its increasing morbidity, lack of well-defined biomarkers and lack of clinically effective treatments. Using metabolomic analysis, the most significantly …

cn (code pays fourni par la source)

The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice

Chuyu Yun, Sen Yan, Baoying Liao, Yong Ding et autres

cn (code pays fourni par la source)

The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α‐ACER2‐Ceramide Signaling Axis

Huiying Liu, Pengcheng Wang, Feng Xu, Qixing Nie et autres

Metabolic abnormalities contribute to the pathogenesis of obesity and its complications. Yet, the understanding of the interactions between critical metabolic pathways that underlie obesity remains to be improved, in part owing to the lack of comprehensive metabolomics studies that reconcile data from …

cn (code pays fourni par la source)

Multi-omics and gut microbiome: Unveiling the pathogenic mechanisms of early-life pesticide exposure

Yifan Yue, Xiaoxuan Sun, Sinuo Tian, Sen Yan et autres

cn (code pays fourni par la source)

Metabolic Dysfunction-Associated Steatohepatitis Detected by Neutrophilic Crown-Like Structures in Morbidly Obese Patients: A Multicenter and Clinicopathological Study

Mengqi Fan, Erfei Song, Yuying Zhang, Pengfei Zhang et autres

Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD), and closely associated with a high risk of liver-related morbidity and mortality. Although enhanced neutrophil infiltration of the liver is a histological hallmark of MASH, the morphological …

cn, ca, au, cz, hk (code pays fourni par la source)

Bifidobacterium mediate gut microbiota-remedied intestinal barrier damage caused by cyproconazole in zebrafish (Danio rerio)

Xiaoxuan Sun, Sinuo Tian, Sen Yan, Wei Sun et autres

cn (code pays fourni par la source)

Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese

Xi Jia, Erfei Song, Yan Liu, Jiarui Chen et autres

The definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein 1 (sCDCP1) as a top-ranked non-invasive biomarker for NASH using Olink-based proteomics in 238 obese individuals with liver biopsies. Both …

hk, cz, cn, ca, au (code pays fourni par la source)