An‐Chun Hwang

High muscle-to-fat ratio predicts slow muscle strength decline in middle-aged and older adults: Longitudinal aging study of Taipei

Ching-Jen Chang, Ming‐Hsien Lin, Liang-Yu Chen, Sung‐Hua Tseng et autres

BACKGROUND: Handgrip strength is a vital marker of muscle function and predictor of health outcomes in older adults. This study investigated the relationship between the muscle-to-fat ratio and 3-year decrease in handgrip strength in community-dwelling adults aged ≥50 years. METHODS: Data were …

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Intrinsic capacity transitions predict overall and cause-specific mortality, incident disability, and healthcare utilization

An‐Chun Hwang, Liang-Yu Chen, Sung-Hua Tseng, Chung-Yu Huang et autres

OBJECTIVES: To develop an intrinsic capacity (IC) score and to investigate the association between IC transition with overall and cause-specific mortality, incident disability and healthcare utilization. DESIGN: Retrospective cohort study SETTING AND PARTICIPANTS: Data from 1852 respondents aged ≥ 65 years who …

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Transitions in Frailty and 4-Year Mortality Risk in Taiwan Longitudinal Study on Aging

An‐Chun Hwang, Liang‐Yu Chen, Ming‐Hsien Lin, Yiing‐Jenq Chou et autres

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Longitudinal changes of frailty in 8 years: comparisons between physical frailty and frailty index

An‐Chun Hwang, Wei‐Ju Lee, Nicole Huang, Liang-Yü Chen et autres

BACKGROUND: Few studies have made longitudinal comparisons between frailty phenotype (FP) and frailty index (FI) changes. We aimed to investigate frailty status changes defined by FP and FI concurrently, and to compare the associated factors and incident disability among different combination of …

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Effects of incorporating multidomain interventions into integrated primary care on quality of life: a randomised controlled trial

Wei‐Ju Lee, Li‐Ning Peng, Chi‐Hung Lin, Ran‐Chou Chen et autres

BACKGROUND: Integrating primary prevention into care pathways for older adults is a core strategy of healthy ageing, but evidence remains limited. We aimed to determine whether incorporating a multidomain intervention into primary health care could improve standard value-based health outcomes and quality …

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CMV infection, CD19+ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly

Liang-Yu Chen, An‐Chun Hwang, Chung-Yu Huang, Liang‐Kung Chen et autres

Abstract Background Chronic infections played a detrimental role on health outcomes in the aged population, and had complex associations with lymphocyte subsets distribution. Our study aimed to explore the predictive roles of chronic infections, lymphopenia, and lymphocyte subsets on unexpected admission and …

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Efficacy of Multidomain Intervention Against Physio-cognitive Decline Syndrome: A Cluster-randomized Trial

Chih‐Kuang Liang, Wei‐Ju Lee, An‐Chun Hwang, Chu‐Sheng Lin et autres

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CMV Infection, CD19+ B Cell Depletion, and Lymphopenia as Predictors for Unexpected Admission in the Institutionalized Elderly

Liang-Yu Chen, An‐Chun Hwang, Chung‐Yu Huang, Liang-Kung Chen et autres

Abstract Background: Chronic infections played a detrimental role on health outcomes in the aged population, and had complex associations with lymphocyte subsets distribution. Our study aimed to explore the predictive roles of chronic infections, lymphopenia, and lymphocyte subsets on unexpected admission and …

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Unfavorable body composition and quality of life among community-dwelling middle-aged and older adults: What really matters?

An‐Chun Hwang, Wei‐Ju Lee, Li‐Ning Peng, Li-Kuo Liu et autres

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Efficacy of multidomain interventions to improve physical frailty, depression and cognition: data from cluster‐randomized controlled trials

Liang‐Kung Chen, An‐Chun Hwang, Wei‐Ju Lee, Li‐Ning Peng et autres

BACKGROUND: Frailty is the pre-eminent exigency of aging. Although frailty-related impairments are preventable, and multidomain interventions appear more effective than unimodal ones, the optimal components remain uncertain. METHODS: We devised multidomain interventions against physical and cognitive decline among prefrail/frail community-dwelling ≥65-year-olds and …

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Carotid Flow Velocities and Blood Pressures Are Independently Associated With Cognitive Function

Shao‐Yuan Chuang, Hao‐Min Cheng, Gary F. Mitchell, Shih‐Hsien Sung et autres

BACKGROUND: Few studies simultaneously addressed associations between carotid flow velocities, blood pressure (BP), and cognitive function. MATERIALS AND METHODS: Subject without dementia (N = 1,684) underwent measurements of BP and biochemical markers. Mini-Mental State Examination (MMSE) and comprehensive neuropsychological tests were used …

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Cognitive Frailty and Its Association with All-Cause Mortality Among Community-Dwelling Older Adults in Taiwan: Results from I-Lan Longitudinal Aging Study

Li-Kuo Liu, Chia‐Hung Chen, Wei‐Ju Lee, Yi‐Hui Wu et autres

The definition of cognitive frailty and its prediction for adverse outcome of community-living older adults remains controversial. This study aims to evaluate the association between cognitive frailty and all-cause mortality among community-living older adults. Data of the I-Lan Longitudinal Aging Study (ILAS) …

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