Paolo Di Gianvincenzo

“Single‐Cell Encapsulation of Lactiplantibacillus Plantarum Via Layer‐by‐Layer Technique for Enhanced Viability and Shelf Life: Insights on Multilayer Assembly on Bacteria”

Nattida Chotechuang, Md Faridunnabi Nayem, Paolo Di Gianvincenzo, Patumporn Manowan et autres

The efficacy of probiotics depends on their ability to survive gastrointestinal transit; however, conventional formulations often experience losses of 2-3 log units before reaching the intestine. Here, we report the single-cell encapsulation of Lactiplantibacillus plantarum C8 using the layer-by-layer (LbL) assembly of …

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Self-assembled supramolecular chiral complexes of alginate and cyanidin-3-O-glucoside: Insights into the molecular basis of assemblies formation

Paolo Di Gianvincenzo, Giulia Ciattaglia, Desiré De Silvio, Apinan Puangpaka et autres

Complexes of cyanidin 3-O-glucoside (CND) and alginate (Alg) form long-range supramolecular structures at pH 4, where CND is predominantly uncharged. Under these conditions, the complexes exhibit pronounced chiroptical activity, with Circular Dichroism (CD) bands significantly more intense than those of free CND …

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Computational Modeling of the Thermodynamics of Non-Covalent Host–Guest Inclusion Complexes

Giulia Ciattaglia, Paolo Di Gianvincenzo, Sergio E. Moya, Isabelle Navizet et autres

Here, we present a general statistical-mechanical model able to reconstruct the temperature dependence of the thermodynamic properties of non-covalent host–guest inclusion complexes using a set of molecular dynamics simulations along an isobar. Our approach, applied to β-cyclodextrin in interaction with E- and …

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Two Complementary Methods for the Measurement of Immunogenic Lipopeptides Critical Micelle Concentration

Jésica A. Rodríguez, Silvia Andrea Camperi, Paolo Di Gianvincenzo, Sergio Enrique Moya

Introduction: Immunogenic lipopeptides are promising immunogens since their amphiphilic nature allows them to assemble into micelles, improving solubility, stability, and circulation half-life [...]

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Synergistic π–π Stacking and Hydrogen Bonding of Doxorubicin Electrostatically Bound to Sodium Alginate Drive the Formation of Supramolecular Nanoparticles with Exceptional Drug Loading

Lucrezia Desiderio, Paolo Di Gianvincenzo, Desirè Di Silvio, Sunisa Thongsom et autres

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Data for: "NANOENCAPSULATION OF 5-FLUOROURACIL IN DERMATAN SULFATE/CHITOSAN NANOPARTICLES IMPROVES TUMOR TREATMENT IN COLORECTAL CANCER"

Agustín Blachman, Ariadna María Birocco, Daniela Poodts, Alejandro Fábrega-Puentes et autres

This repository contains data associated with the results presented in Blachman, A., Birocco, A., Poodts, D., Fábrega-Puentes, A., Subrati, A., Di Gianvincenzo, P., Moya, S., and Calabrese, C.: "Nanoencapsulation of 5-Fluorouracil in Dermatan Sulfate/Chitosan nanoparticles improves tumor treatment in colorectal cancer"

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Data for: "NANOENCAPSULATION OF 5-FLUOROURACIL IN DERMATAN SULFATE/CHITOSAN NANOPARTICLES IMPROVES TUMOR TREATMENT IN COLORECTAL CANCER"

Agustín Blachman, Ariadna María Birocco, Daniela Poodts, Alejandro Fábrega-Puentes et autres

This repository contains data associated with the results presented in Blachman, A., Birocco, A., Poodts, D., Fábrega-Puentes, A., Subrati, A., Di Gianvincenzo, P., Moya, S., and Calabrese, C.: "Nanoencapsulation of 5-Fluorouracil in Dermatan Sulfate/Chitosan nanoparticles improves tumor treatment in colorectal cancer"

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Barium Titanate-Coated Cobalt Ferrite Core–Shell Magnetoelectric Nanoparticles for Wireless Actuation Technologies

Vicente Durán-Toro, Ryan W. Crisp, Elif Koçar, Franziska Wasner et autres

We report a deposition pathway for barium titanate (BTO) onto hydrophobically coated cobalt ferrite (CFO) nanoparticles, resulting in the formation of magnetoelectric core-shell nanoparticles. Our strategy utilizes a bimetallic Ba and Ti oleate (BTOle) precursor, which hydrophobically interacts with dimethyl-dioctadecyl-ammonium bromide (DDAB)-stabilized …

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“Self‐Assembly of Branching and Linear Synthetic Polycationic Peptides in Phosphate Buffer and Its Impact on Antimicrobial Activity”

Rotimi Sheyi, Paolo Di Gianvincenzo, Siwanut Pummarin, Desirè Di Silvio et autres

ABSTRACT Among therapeutic peptides, antimicrobial peptides (AMPs) have gained significant attention for their potential to combat antimicrobial resistance. Their efficacy often relies on the ability to adopt organized structures, such as α‐helices or β‐strands. However, the formation of supramolecular aggregates can hinder …

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Lauryl-NrTP6 lipopeptide self-assembled nanorods for nuclear-targeted delivery of doxorubicin

Amanda Phungula, Sofia Zuffi, Sunisa Thongsom, Paolo Di Gianvincenzo et autres

(NrTP6) and two lauric acid chains are used to encapsulate the chemotherapeutic agent doxorubicin (DX) through a solvent-exchange protocol. LPs spontaneously form nanosized rod-like assemblies in phosphate buffer. DX is trapped in the peptide regions of the assemblies. Confocal laser scanning microscopy …

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Supramolecular dextran/polyamine phosphate nanocapsules with smart responsiveness for encapsulation of therapeutics

Aharon Steffè, Francesca Milano, Santiago Giménez Reyes, Francesca Buco et autres

polymers form supramolecular assemblies. Physico chemical characteristics and pH responsiveness of the assemblies are correlated with the number of dextran chains per PAH molecule. Nanocapsules (NCs) are formed when PAH:DEX ratio is 1. Capsule formation is explained by the branched nature of …

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Enhanced anticancer activity of N,N-bis(5-ethyl-2-hydroxybenzyl)methylamine (EMD) hydrophobic drug encapsulated in β-cyclodextrin nanosponges

Sunisa Thongsom, Paolo Di Gianvincenzo, Suchittra Konkankun, Agustín Blachman et autres

N, N- bis (5-ethyl-2-hydroxybenzyl) methylamine (EMD) is a synthetic benzoxazine dimer compound. EMD targets and degrades the pro-oncogenic transcription factor c-Myc, initiating apoptosis in cancer cells. However, its use is restricted because of poor aqueous solubility and in physiological media. Cyclodextrin nanosponges …

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