Accès ouvert
2026
article
OpenAlex
Xin Li, Cynthia Lebeaupin, Aikaterini Kadianaki, Clementine Druelle-Cedano et autres
Abstract Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies 1 . Although endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR transducer ATF6α remains …
de, us, es, ch, cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Philipp Hafner, S. Keller, Xun Chen, Asma Alrawashdeh et autres
Oncogenic KRAS mutations drive metabolic reprogramming in pancreatic ductal adenocarcinoma (PDAC). Src-homology 2 domain-containing phosphatase 2 (SHP2) is essential for full KRAS activity, and promising dual SHP2/mitogen-activated protein kinase (MAPK) inhibition is currently being tested in clinical trials. Exploitable metabolic adaptations may …
de, cn, ch
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
T. Rückert, G. Andrieux, M. Boerries, N. M. Woessner et autres
Background: Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy option for patients with hematological malignancies. Acute graft-versus-host disease (GVHD) is primarily driven by allogeneic donor T cells and remains a serious cause of morbidity and mortality post allo-HCT. In particular, acute …
de, gb, dk
(code pays fourni par la source)