Jason Schultz

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases

Nan Zhang, Brittani Bewick, Jason Schultz, Anjana Tiwari et autres

CAG repeat expansion is the genetic cause of nine incurable polyglutamine (polyQ) diseases with neurodegenerative features. Silencing repeat RNA holds great therapeutic value. Here, we developed a repeat-based RNA-cleaving DNAzyme that catalyzes the destruction of expanded CAG repeat RNA of six polyQ …

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Contribution of 5′- and 3′-untranslated regions of plastid mRNAs to the expression of Chlamydomonas reinhardtii chloroplast genes

Dwight Barnes, Scott Franklin, Jason Schultz, Ryan E. Henry et autres

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Development of a luciferase reporter gene, luxCt, for Chlamydomonas reinhardtii chloroplast

Stephen P. Mayfield, Jason Schultz

Luciferase reporter genes have been successfully used in a variety of organisms to examine gene expression in living cells, but are yet to be successfully developed for use in chloroplast. Green fluorescent protein (gfp) has been used as a reporter of chloroplast …

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