Leonidas Benetatos

Transcriptomic and miRNA–Target Pathway Analysis of the DLK1-DIO3 Imprinted microRNA Cluster in Chronic Lymphocytic Leukemia

Γεώργιος Μαρκόπουλος, Yannis V. Simos, Konstantinos I. Tsamis, Lampros Lakkas et autres

Background/Objectives: Chronic lymphocytic leukemia (CLL) is a heterogeneous B-cell malignancy in which B-cell receptor signaling, microenvironmental interactions, genomic lesions, and epigenetic deregulation cooperate to shape disease behavior. The imprinted DLK1-DIO3 locus at chromosome 14q32 contains the largest human miRNA cluster and has …

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Systems Biology Analysis of DLK1-DIO3 Imprinted microRNAs Cluster in Chronic Lymphocytic Leukemia

Γεώργιος Μαρκόπουλος, Yannis V. Simos, Konstantinos I. Tsamis, Lampros Lakkas et autres

Chronic lymphocytic leukemia (CLL) is a biologically heterogeneous B-cell malignancy in which B-cell receptor signaling, microenvironmental interactions, genomic lesions, and epigenetic deregulation cooperate to shape disease behavior. The imprinted DLK1-DIO3 locus at chromosome 14q32 contains the largest human miRNA cluster and has …

Real‐World Outcomes in NPM1 ‐Mutated Acute Myeloid Leukemia: The Impact of Measurable Residual Disease on Disease Relapse

Panagiotis Tsirigotis, Maria Garofalaki, Ioanna Lazana, Maria Liga et autres

The prognostic value of NPM1-mut Measurable Residual Disease (MRD) has been increasingly recognized. However, real-world data validating the prognostic impact of NPM1-mut MRD remains limited. The aim of this study was to assess the prognostic value of NPM1-mut MRD and to explore …

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Decoding Leukemic Stem Cells in AML: From Identification to Targeted Eradication

Elisavet Apostolidou, Vasileios Georgoulis, Dimitrios Leonardos, Leonidas Benetatos et autres

Acute myeloid leukemia (AML) continues to pose significant therapeutic challenges, with high relapse rates driven largely by leukemic stem cells (LSCs), a rare, therapy-resistant population with self-renewal capacity, niche adaptation, and the ability to re-initiate disease. In this state-of-the-art review, we synthesize …

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Decoding Leukemic Stem Cells in AML: From Identification to Targeted Eradication

Elisavet Apostolidou, Vasileios Georgoulis, Dimitrios Leonardos, Leonidas Benetatos et autres

Acute myeloid leukemia (AML) continues to pose significant therapeutic challenges, with high relapse rates driven largely by leukemic stem cells (LSCs), a rare, therapy-resistant population with self-renewal capacity, niche adaptation, and the ability to re-initiate disease. In this state-of-the-art review, we synthesize …

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Treatability with ibrutinib plus venetoclax in patients with CLL in the real-world. the eric international thrive study

Andrea Visentin, Thomas Chatzikonstantinou, Lydia Scarfò, Persefoni Talimtzi et autres

Abstract Background. Clinical trials have documented the efficacy of ibrutinib in combination with venetoclax in CLL. Indeed, Ibrutinib plus venetoclax (I+V) is the first all oral fixed duration treatment approved for treatment naive patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) …

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Applications of Multiparameter Flow Cytometry in the Diagnosis, Prognosis, and Monitoring of Multiple Myeloma Patients

Dimitrios Leonardos, Leonidas Benetatos, Elisavet Apostolidou, Epameinondas Koumpis et autres

Multiple myeloma (MM) is one of the most common hematological malignancies and remains incurable. However, the survival of multiple myeloma patients has significantly increased due to the implementation of novel therapies along with autologous stem cell transplantation, changing the natural history of …

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Exportin-1 and epigenetic modifications interaction: more than nuclear transport

Leonidas Benetatos, Eleftheria Hatzimichael, Eleni Kapsali

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Applications of Multiparameter Flow Cytometry in the Diagnosis, Prognosis and Monitoring of Multiple Myeloma Patients

Dimitrios Leonardos, Leonidas Benetatos, Elisavet Apostolidou, Epameinondas Koumpis et autres

Multiple myeloma (MM) is one of the most common hematological malignancies and remains incurable. However, survival of multiple myeloma patients has significantly increased due to the implementation of novel therapies along with autologous stem cell transplantation, changing the natural history of the …

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Targeting the undruggable MYC in cancer: the rationale of using XPO1 inhibitors

Leonidas Benetatos, Eleftheria Hatzimichael, Eleni Kapsali

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Embryonic transcription and epigenetics: root of the evil

Leonidas Benetatos, George Vartholomatos

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Luspatercept: A New Tool for the Treatment of Anemia Related to β-Thalassemia, Myelodysplastic Syndromes and Primary Myelofibrosis

Eleftheria Hatzimichael, Despoina Timotheatou, Epameinondas Koumpis, Leonidas Benetatos et autres

Anemia is a common feature of both benign and malignant hematologic diseases. Beta-thalassemia (β-thalassemia) syndromes are a group of hereditary disorders characterized by ineffective erythropoiesis, due to a genetic deficiency in the synthesis of the beta chains of hemoglobin, often accompanied by …

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