Justin T. Jacob

Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging

Andrew J. Einstein, Michelle C. Williams, Jonathan Weir-McCall, Leslee J. Shaw et autres

Importance: In recent decades, there has been marked worldwide growth in diagnostic testing for coronary artery disease (CAD), with several common imaging modalities exposing patients to ionizing radiation. Objective: To examine worldwide radiation doses for patients undergoing noninvasive CAD diagnostic testing. Design, …

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Tumor Treating Fields (TTFields) after Stereotactic Radiosurgery (SRS) for Brain Metastases from Non-Small Cell Lung Cancer (NSCLC BM): Final Results of The Phase 3 METIS Trial

V. Gondi, M. Ahluwalia, D. Roberge, Rosanda Ilić et autres

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Outcomes and Toxicities of Stereotactic Radiosurgery for Large Brainstem Metastases

J.F. Oyeniyi, J.S. Lee, Yastira Ramdas, Z.A. Seymour et autres

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Nuclear roles for non-lamin intermediate filament proteins

Pierre A. Coulombe, Christopher M. Pineda, Justin T. Jacob, Raji R. Nair

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P355: MINI-HYPER-CVD PLUS INOTUZUMAB OZOGAMICIN, WITH OR WITHOUT BLINATUMOMAB, IN OLDER ADULTS WITH NEWLY DIAGNOSED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: UPDATES FROM A PHASE II TRIAL

Fadi Haddad, H. Kantarjian, N. Short, Farhad Ravandi et autres

Background: Blinatumomab (Blina) and inotuzumab ozogamicin (INO) improve the outcomes of patients (pts) with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). These drugs may allow for use of less chemotherapy and improve remission durations and overall survival (OS) in older pts with newly …

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A role for keratin 17 during DNA damage response and tumor initiation

Raji R. Nair, Joshua Hsu, Justin T. Jacob, Christopher M. Pineda et autres

High levels of the intermediate filament protein keratin 17 (K17) are associated with poor prognoses for several human carcinomas. Studies in mouse models have shown that K17 expression is positively associated with growth, survival, and inflammation in skin and that lack of …

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Bone Mineral Density: Clinical Relevance and Quantitative Assessment

Katherine Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob et autres

Bone mineral density (BMD) measurement by dual-energy x-ray absorptiometry (DXA) is an internationally accepted standard-of-care screening tool used to assess fragility-fracture risk. Society guidelines have recommended which populations may benefit from DXA screening and the use of the fracture risk assessment tool …

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Keratin 17 regulates nuclear morphology and chromatin organization

Justin T. Jacob, Raji R. Nair, Brian G. Poll, Christopher M. Pineda et autres

ABSTRACT Keratin 17 (KRT17; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences in nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit flatter nuclei …

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Keratin 17 regulates nuclear morphology and chromatin organization

Justin T. Jacob, Raji R. Nair, Brian G. Poll, Christopher M. Pineda et autres

Abstract Keratin 17 ( KRT17 ; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences in nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit …

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Nuclear Medicine Advanced Associates: Physician Extenders in Nuclear Medicine—Now Is the Time

Mary Anne Owen, Katie Neal Sinotte, Norman E. Bolus, Richard Siska et autres

From its inception in 2008 until 2020, the nuclear medicine advanced associate (NMAA) has evolved into a valuable member of the imaging team. Data show that NMAAs perform key services including supervision, interpretation, protocoling of adjunct studies, and management, freeing nuclear medicine …

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Prospective evaluation of oral premalignant lesions using a multimodal imaging system: a pilot study

Eric Yang, Imran S. Vohra, Hawraa Badaoui, Richard A. Schwarz et autres

BACKGROUND: Multimodal optical imaging, incorporating reflectance and fluorescence modalities, is a promising tool to detect oral premalignant lesions in real-time. METHODS: Images were acquired from 171 sites in 66 patient visits for clinical evaluation of oral lesions. An automated algorithm was used …

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926 Keratin 17: A novel regulator of nuclear morphology and chromatin organization

Justin T. Jacob, Michael J. Matunis, Raji R. Nair, Pierre A. Coulombe

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