Helen Tang

Anionic Lipids Regulate the Light-Harvesting Complex 1-Reaction Center Photocycle in Purple Bacteria

Olivia C. Fiebig, Neetu Singh Yadav, Dihao Wang, Muath Nairat et autres

Photosynthetic purple bacteria can capture and convert sunlight with a remarkable, nearly 100% quantum efficiency. The light-harvesting complex 1-reaction center (LH1-RC) core complex is the membrane complex fundamentally responsible for solar energy conversion. LH1-RC has a highly conserved surrounding lipid composition known …

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Efficacy of probiotic treatment as post-exposure prophylaxis for COVID-19: A double-blind, Placebo-Controlled Randomized trial

Lauren Bohannon, Yi Ren, Tessa M. Andermann, David Hebbelstrup Jensen et autres

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Clinical outcomes and care for spontaneous bacterial peritonitis: A national cohort study

Marina Serper, Helen Tang, Siqi Zhang, David E. Kaplan et autres

BACKGROUND AND AIMS: Spontaneous bacterial peritonitis (SBP) leads to high rates of acute kidney injury (AKI), hepatorenal syndrome, and mortality. Population-based studies on contemporary SBP epidemiology are needed to inform care. In a large, national cohort of patients diagnosed with SBP and …

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Trends in surgical volume and mortality by surgery type among patients with cirrhosis: A Veterans Affairs study

Helen Tang, David E. Kaplan, Nadim Mahmud

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Recent TIPS increases postoperative mortality: A national cohort study

Helen Tang, David E. Kaplan, Samir Abu‐Gazala, Nadim Mahmud

BACKGROUND: Patients with cirrhosis have an increased risk of postoperative mortality, which is partially attributable to portal hypertension. Preoperative TIPS placement may reduce operative risk. Studies suggesting the benefits of preoperative TIPS are limited by residual confounding and lack of longitudinal laboratory …

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Ibrutinib for therapy of steroid-refractory chronic graft-versus-host disease: a multicenter real-world analysis

Joseph A. Pidala, Jongphil Kim, Denise Kalos, Corey Cutler et autres

ABSTRACT: To examine the activity of ibrutinib in steroid-refractory chronic graft-versus-host disease (SR-cGVHD) after the US Food and Drug Administration approval, we conducted a multicenter retrospective study. Data were standardly collected (N = 270 from 19 centers). Involved organs included skin (75%), …

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S1726 Trends in Surgical Volume and Procedure Type Among Patients with Cirrhosis: A Veterans Affairs Study

Helen Tang, Nadim Mahmud

Introduction: Cirrhosis is associated with increased perioperative risk, yet cirrhosis itself may also potentially increase the need for surgical procedures. Furthermore, the population of elderly patients with cirrhosis in the United States has increased over time, which may confer additional risk in …

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Impact of Multiple Episodes of Cytomegalovirus Infection on Patient Outcomes in Allogeneic Hematopoietic Stem Cell Transplant Using a Pre-emptive Monitoring Strategy

Julia A. Messina, Jennifer L. Saullo, Steven P. Wolf, Yanhong Li et autres

Abstract The impact of multiple episodes of clinically significant cytomegalovirus infection (csCMVi) on clinical outcomes during pre-emptive CMV monitoring in allogeneic hematopoietic stem cell transplant recipients (HCT) is not well understood. We performed a retrospective cohort study of all consecutive patients undergoing …

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Preliminary results of a phase 1, first-in-human, dose escalation study of the anti-CCR8 cytolytic antibody, CHS-114 (formerly SRF114) in patients with advanced solid tumors.

Amita Patnaik, Justin Call, William Bennion McKean, Drew Rasco et autres

2664 Background: Depletion of intratumoral regulatory T cells (itTregs) represents an attractive therapeutic strategy to enhance antitumor responses. The chemokine receptor CCR8 is preferentially expressed on itTregs compared to peripheral Tregs and other immune cell types, and CCR8 expressing itTregs are highly …

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Su1556 WEIGHT LOSS PROGRAMS AND BMI TRAJECTORY IN PATIENTS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE: A VETERANS HEALTH ADMINISTRATION STUDY

Helen Tang, David E. Kaplan, Nadim Mahmud

Waitlisting and liver transplantation for MetALD in the United States: An analysis of the UNOS national registry

Pedro Ochoa‐Allemant, Marina Serper, Roy Wang, Helen Tang et autres

BACKGROUND AND AIMS: The new steatotic liver disease (SLD) nomenclature introduced metabolic and alcohol-associated liver disease (MetALD), describing the intersection of metabolic dysfunction-associated steatotic liver disease and alcohol-associated liver disease. Waitlisting and liver transplantation for MetALD are not well defined. We aimed …

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Performance of Urinalysis Parameters in Predicting Urinary Tract Infection: Does One Size Fit All?

Sonali D. Advani, Rebecca L. North, Nicholas Turner, Sahra Ahmadi et autres

In a multihospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria or nitrite) performed better than pyuria alone for ruling out UTI. However, performance of all urinalysis …

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