Lindsey Heathcock

Advocating For a Culture of Support for Lactating Medical Residents in Hawai'i.

Kara Wong Ramsey, Nina Beckwith, Lindsey Heathcock, Tony Myers et autres

Lactating medical residents face unique barriers due to intense clinical work schedules, limited support in the clinic and hospital workspaces, and competing pressures between career development and childcare. The objective of this project was to explore the perceived culture of breastfeeding support …

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Abstract 5270: IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II-III diffuse gliomas

Adriana Olar, Khalida Wani, Kristin Diefes, Lindsey Heathcock et autres

Abstract Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of tumors. The role of tumor grade and mitotic index in patient outcome has not been evaluated following …

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DNA copy number analysis of Grade II–III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status

Adam L. Cohen, Mariko Sato, Kenneth Aldape, Clinton C. Mason et autres

INTRODUCTION: Isocitrate dehydrogenase (IDH) mutation status and grade define subgroups of diffuse gliomas differing based on age, tumor location, presentation, and prognosis. While some biologic differences between IDH mutated (IDH (mut)) and wild-type (IDH (wt)) gliomas are clear, the distinct alterations associated …

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IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas

Adriana Olar, Khalida Wani, Kristin Alfaro-Munoz, Lindsey Heathcock et autres

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NEURO/MEDICAL ONCOLOGY

Prakash Ambady, Matthias Holdhoff, Cássio Ricardo Auada Ferrigno, S. Grossman et autres

BACKGROUND: The treatment of patients with primary CNS lymphomas (PCNSL) has dramatically changed since the 1970's when whole brain radiation generated median survivals of about 12 months, significant neurotoxcity, and few long term survivors.High dose methotrexate (HD-MTX) monotherapy without radiation provides excellent …

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OMICS AND PROGNSTIC MARKERS

Kazuhide Adachi, H Sasaki, Shinya Nagahisa, Kentarou Yoshida et autres

Although histopathological diagnosis is essential in decision of therapeutic strategy for gliomas, sometimes the tumors diagnosed in one histological entity show thoroughly different clinical courses.This phenomenon is believed to be due primarily to the presence of the genetic subgroup.In fact, relationship between …

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Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

Krishna Bhat, Veerakumar Balasubramaniyan, Brian Vaillant, Ravesanker Ezhilarasan et autres

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Abstract A08: Chromothripsis and gene-specific copy number aberrations associated with mutation of IDH1 in glioma

Howard Colman, Mariko Sato, Clinton C. Mason, Kristin Diefes et autres

Abstract Background: IDH gene mutation in gliomas is associated with younger age and better survival. IDH1 mutation has also been demonstrated to cause global hypermethylation and G-CIMP phenotype in astrocytes. However, the effects of IDH mutation and hypermethylation on molecular ontogeny and …

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A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival

Siyuan Zheng, Jun Fu, Rahulsimham Vegesna, Yong Mao et autres

With the advent of high-throughput sequencing technologies, much progress has been made in the identification of somatic structural rearrangements in cancer genomes. However, characterization of the complex alterations and their associated mechanisms remains inadequate. Here, we report a comprehensive analysis of whole-genome …

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Use of DNA copy number analysis of grade 2-4 gliomas to reveal differences in molecular ontogeny associated with IDH mutation status.

Mariko Sato, Kenneth Aldape, Clinton C. Mason, Kristin Diefes et autres

2026 Background: The genetic alterations of glioma have been studied extensively. IDH1 mutation is associated with younger age and better survival. However, differences in molecular ontogeny within glioma related to IDH1 mutation remain unknown. Here we describe a detailed analysis of copy …

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Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution

Sandra Boots‐Sprenger, Angelique Sijben, Jos Rijntjes, Bastiaan B.J. Tops et autres

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Abstract 887: Development of a robust nanoimmunoassay and immunohistochemical assay for asparagine synthetase

Philip L. Lorenzi, Lindsey Heathcock, Kenneth Aldape, John N. Weinstein

Abstract The enzyme-drug L-asparaginase (L-ASP) has been used for four decades to treat acute lymphoblastic leukemia. However, its unique mechanism of action is still poorly understood, and its clinical efficacy has proven unpredictable. Those problems have prompted a continuing search for biomarkers …

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