Paolo Spina

Mechanical Thrombectomy in Patients With Cervical Artery Dissection: A Multicenter Analysis on Technical, Safety, and Functional Outcomes

Francesco Favruzzo, Marialuisa Zedde, Luca Weis, Rosario Pascarella et autres

ABSTRACT Background and Aims The safety and effectiveness of mechanical thrombectomy (MT) in patients with cervical artery dissection (CeAD) remain uncertain. This study aimed to evaluate the safety, recanalization rates, and functional outcomes of MT in LVO‐AIS patients with and without CeAD. …

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P05.06.B CLINICAL USEFULNESS OF MGMT PROMOTER METHYLATION QUANTIFICATION IN GBM PATIENTS TREATED WITH CHEMO-RADIATION THERAPY

Barbara Muoio, Samantha Epistolio, Francesco Polinelli, Ismail Zaed et autres

Abstract BACKGROUND In glioblastoma (GBM) patients two factors are relevant for prediction of survival: MGMT promoter hypermethylation, which improves the patient’s response to temozolomide (TMZ), and the extent of resection (EOR), with a better overall survival (OS) described in patients subjected to …

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Sex-Related Differences in Glioblastoma: A Single-Center Retrospective Cohort Study

Chiara Prosperetti, Alberto Pagnamenta, Payam Tabaee Damavandi, Giulio Disanto et autres

Background: Sex differences play a significant role in the epidemiology, biology, and outcomes of many cancers, including glioblastoma (GB), the most common and aggressive primary brain tumor. GB is more frequent in males, while females tend to have longer survival, though the …

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The Clinical Role of miRNAs in the Development and Treatment of Glioblastoma

Samantha Epistolio, Paolo Spina, Ismail Zaed, Andrea Cardia et autres

Glioblastoma multiforme (GBM) is the most common brain tumor and one of the most aggressive, with a median overall survival (OS) of only 15-18 months. These characteristics make it necessary to identify new targets for the improvement of prognosis and better prediction …

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Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer

Raffaello Roesel, Francesco Strati, Camilla Basso, Samantha Epistolio et autres

Locally advanced rectal cancer (LARC) is treated with neoadjuvant chemo-radiotherapy (nCRT) followed by surgery. A minority of patients show complete response (CR) to nCRT and may avoid surgery and its functional consequences. Instead, most patients show non-complete response (non-CR) and may benefit …

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The Clinical Role of miRNAs in the Development and Treatment of Glioblastoma

Samantha Epistolio, Paolo Spina, Ismail Zaed, Andrea Cardia et autres

Glioblastoma multiforme (GBM) is the most common brain tumour and one of the most aggressive, with a median overall survival (OS) of only 15-18 months. These characteristics make it necessary to identify new targets for the improvement of prognosis and better prediction …

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Patterns and predictors of statin therapy after ischemic stroke and TIA: insights from the LIPYDS multicenter study

Angelo Cascio Rizzo, Ghil Schwarz, Matteo Paolucci, Anna Cavallini et autres

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Calcified uterine leiomyoma from an 18th-century nunnery in North Italy

Roberta Fusco, Chiara Tesi, Paolo Spina, Ezio Fulcheri et autres

OBJECTIVE: To develop a differential diagnosis of a mass retrieved alongside skeletal remains in the crypt of the church of Santissima Annunziata of Valenza (Province of Alessandria, Northern Italy). MATERIAL: A calcified mass measuring 40 × 39 mm and 17.62 × 16.3817.62 …

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Clinical Relevance and Interplay between miRNAs in Influencing Glioblastoma Multiforme Prognosis

Samantha Epistolio, Giulia Dazio, Ismail Zaed, Nora Sahnane et autres

Glioblastoma multiforme (GBM) is usually treated with surgery followed by adjuvant partial radiotherapy combined with temozolomide (TMZ) chemotherapy. Recent studies demonstrated a better survival and good response to TMZ in methylguanine-DNA methyltransferase (MGMT)-methylated GBM cases. However, approximately 20% of patients with MGMT-unmethylated …

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Abstract TP180: Characteristics and Outcomes of Cerebral Venous Sinus Thrombosis Associated With COVID-19

Adrian Scutelnic, Anita van de Munckhof, Angel Miaclin, Sanjith Aaron et autres

Background: Coronavirus disease 2019 (COVID-19) increases the risk of cerebral venous sinus thrombosis (CVST), and previous reports derived from small case series reported a high mortality in these patients, up to 40%. We assessed the clinical characteristics and outcomes in an international …

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A qPCR technology for direct quantification of methylation in untreated DNA

Kamilla Kolding Bendixen, Maria Mindegaard, Samantha Epistolio, Giulia Dazio et autres

DNA methylation is important for gene expression and alterations in DNA methylation are involved in the development and progression of cancer and other major diseases. Analysis of DNA methylation patterns has until now been dependent on either a chemical or an enzymatic …

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Susceptibility to brain ischemia and the association between migraine and spontaneous cervical artery dissection

Elisabetta Del Zotto, Mario Grassi, Marialuisa Zedde, Andrea Zini et autres

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