N A Malkova

The use of divozilimab in real-world clinical practice: a prospective, single-centre study

I.E. Arkhipov, Anna I. Prokaeva, E. V. Tretyakova, A. A. Melnikova et autres

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, the pathogenesis of which is underpinned by a combination of autoinflammatory and neurodegenerative processes. Divozilimab (DIV) is the first monoclonal antibody from the anti-CD20 therapy group to be developed …

ru (code pays fourni par la source)

SibBMS: Siberian Brain Multiple Sclerosis Dataset with lesion segmentation and patient meta information

Bair Tuchinov, Anna I. Prokaeva, Liubov M. Vasilkiv, Yu. A. Stankevich et autres

Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disorder of the central nervous system (CNS) and represents the leading cause of non-traumatic disability among young adults. Magnetic resonance imaging (MRI) has revolutionized both the clinical management and scientific understanding of MS, serving …

ru (code pays fourni par la source)

Results of medical and social research and assessment of quality of life in myasthenia gravis

I. V. Vlasov, Yu. A. Merkulov, В. М. Алифирова, M V Abroskina et autres

Myasthenia gravis (MG) is one of the most common autoimmune diseases of the nervous system. Medical and social analysis of the patient population structure and assessment of their quality of life (QoL) as one of the criteria for the effectiveness of treatment …

ru, us, de (code pays fourni par la source)

SibBMS: Siberian Brain Multiple Sclerosis Dataset with lesion segmentation and patient meta information

Bair Tuchinov, Anna I. Prokaeva, Liubov M. Vasilkiv, Yu. A. Stankevich et autres

Abstract Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disorder of the central nervous system (CNS) and represents the leading cause of non-traumatic disability among young adults. Magnetic resonance imaging (MRI) has revolutionized both the clinical management and scientific understanding of MS, …

ru (code pays fourni par la source)

Epidemiology of multiple sclerosis in the city of Novosibirsk

I.E. Arkhipov, Anna I. Prokaeva, E.V. Tretyakova, D. S. Korobko et autres

Objective. To study the dynamics of the epidemiological characteristics of multiple sclerosis (MS) from 01.01.2003 to 01.01.2024 in Novosibirsk in comparison with the previous 20-year study. Material and methods. The prevalence cohort included 2254 patients with MS living in Novosibirsk on 01.01.2024. …

ru (code pays fourni par la source)

Discovering predictive features of multiple sclerosis from clinically isolated syndrome with machine learning

Minh Sao Khue Luu, Bair Tuchinov, Anna I. Prokaeva, D. S. Korobko et autres

Accurately predicting the progression of clinically isolated syndrome (CIS) to multiple sclerosis (MS) is crucial for early intervention and management. This study employs a range of machine learning models, including categorical boosting, extreme gradient boosting, light gradient boosting machine, random forest, support …

Hyperreflective focuses as a biomarker of multiple sclerosis progression

А. Ж. Фурсова, M Yu Zubkova, M A Vasilyeva, Yu. A. Gamza et autres

Purpose: to identify the intraretinal hyperreflective foci (HRF), their specific characteristics, localization features and correlations with the duration of the disease, type of course and previous episodes of optic neuritis (ON) in multiple sclerosis (MS) patients using a high-resolution OCT scanning protocol. …

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EVALUATION OF THE STATE OF THE TELETSKOYE LAKE WATER RESOURCES

A.I. Davydov, Nikolay Erin, N A Malkova, Aleksey Drobyshev

For practical solution of the problems of the national water sector to preserve natural reservoirs in their natural conditions, it is of interest to study the dynamics of their condition, as this provides information for optimizing their use and management. The priorities …

Long-term efficacy and safety of divozilimab during 2-year treatment of multiple sclerosis patients in randomized double-blind placebo-controlled clinical trial BCD-132-4/MIRANTIBUS

Alexey Boykо, В. М. Алифирова, И Г Лукашевич, З. А. Гончарова et autres

Objective. To evaluate the efficacy and safety of the anti-CD20 monoclonal antibody divozilimab (DIV) used as an intravenous infusion at a dose of 500 mg every 24 weeks during 100 weeks for the treatment of patients with multiple sclerosis (MS), including relapsing-remitting …

ru, us (code pays fourni par la source)

Multiple sclerosis: modern diagnostic markers and prognostic factors of disease progression

Anna I. Prokaeva, I.E. Arkhipov, E. E. Dorchinets, D. S. Korobko et autres

Multiple sclerosis (MS) is one of the most common causes of disability in young people of working age. The prevalence of this disease has increased significantly in recent years and today amounts to more than 2 900 000 people worldwide. The transition …

ru (code pays fourni par la source)

COVID-19 and multiple sclerosis: is there a connection?

I.E. Arkhipov, Anna I. Prokaeva, A. V. Zateev, V. K. Kozyreva et autres

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system, which is based on inflammatory demyelination and neurodegeneration. Over the course of the COVID-19 pandemic, there has been a perception that the virus has an effect on the course …

ru (code pays fourni par la source)

Modern diagnostic potentials of studying structural and functional changes of the retina and the optic nerve in multiple sclerosis patients

А. Ж. Фурсова, M Yu Zubkova, M A Vasilyeva, Yu. A. Gamza et autres

Purpose: to study significant functional and structural changes in the retina and the intraocular section of the optic nerve in multiple sclerosis (MS) patients and analyze how they are interrelated with electrophysiological changes in the visual analyzer. Materials and methods. The study …

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