Natarajan Muthusamy

Identifying the angiogenic receptor expression in mantle cell lymphoma patients and murine models

Satishkumar Singh, Y S Wang, Anuvrat Sircar, Udita Jindal et autres

Mantle Cell Lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma, with frequent relapses and shorter responses with every subsequent treatment. MCL depends on growth factors and cytokines derived from microenvironmental cells for its growth and can alter the immune system to evade …

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Exploration of a green route for the synthesis of biological and environmentally applicative zinc oxide/silver/chitosan nanocomposite

Kanniah Paulkumar, Chelliah Parvathiraja, Subburathinam Balakrishnan, Jeyakumar Palanisamy et autres

The current research work reports the preparation of zinc oxide/silver/chitosan (ZnO/Ag/CHS) nanocomposite using the tuber extract of Curcuma longa (C. longa). Analytical techniques like X-ray diffraction (XRD) and UV-Vis spectroscopy were carried out in order to confirm the production of ZnO/Ag nanoparticles …

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PO-05-101 ROLE OF PROTEIN PHOSPHATASE 2A-B56Α IN REGULATION OF THE ARRHYTHMOGENIC LATE SODIUM CURRENT

Nipun Malhotra, Hassan Musa, Mei Han, Xianyao Xu et autres

Comparative efficacy of acaricides on tick infestation in dairy cattle

Natarajan Muthusamy, V. Sankar, M. Murugan, K. Velmurugan

The present study aimed to evaluate the acaricidal activity of TANUVAS nanomethicone, polyherbal spray, and deltamethrin in crossbred dairy cattle.This study was conducted at Naraikinaru and Pillipakuttai villages in Namakkal district.A total of 20 animals were randomly distributed in 4 groups, with …

Abstract 4140343: Role of a novel protein phosphatase 2A activating drug in the regulation of late sodium current.

Nipun Malhotra, Michael B. Wallace, Hassan Musa, S Takenaka et autres

Introduction: The voltage-gated Na + channel, Na v 1.5, plays a leading role in the regulation of myocyte excitability and cardiac function. However, a small “late” component of Na v current I Na ( I Na,L ) increases in response to enhanced …

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Tumor Microenvironment-Induced Interleukin-6 Regulates Proliferation and Survival in Patients with Mantle Cell Lymphoma (MCL) By Activating FGFR1 Signaling

Satishkumar Vishram Singh, Audrey Odier, Alessandro La Ferlita, Wing Keung Chan et autres

Introduction: Mantle Cell Lymphoma (MCL) is a rare and aggressive subtype of B-cell lymphoma with a median survival of 4 years, although this has been improved over the past decade with the advent of small molecule inhibitors and cellular therapies. However, resistance …

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Transcriptomic Analysis in Mantle Cell Lymphoma Patients Identified MALAT1 Long-Non-Coding RNA to Regulate Cell Cycle Progression By Modulating EZH2/p57/Sox11 Axis

Satishkumar Vishram Singh, Alessandro La Ferlita, Neeraj Kumar Jain, M R Berger et autres

Introduction: Mantle Cell Lymphoma (MCL), a rare and incurable form of B-cell lymphoma, presents significant challenges in treatment, with limited median progression-free survival. MCL is characterized by the translocation t(11;14) leading to overexpression of the cyclinD1 and deregulation of the cell cycle …

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Molecular identification of contagious ecthyma in Kanni and Kodi goats breeds of Virudhunagar district, Tamil Nadu

MS Murgan, V. Palanichamy, Muthukrishnan Madhanmohan, TV Meenambigai et autres

Goat farming plays a pivotal role in income generation for rural households in Virudhunagar district, providing a reliable source of livelihood and economic stability for many families. However, the present study highlights a potential threat to this vital sector, as it investigated …

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CD37 in acute myeloid leukemia: a novel surface target for drug delivery

Erin G. Jeremy, Esthela J. Artiga, Sara Elgamal, Carolyn M. Cheney et autres

ABSTRACT: Acute myeloid leukemia (AML) is the most common and lethal leukemia in adults. AML consists of many genetic subtypes, which limits broad applicability of targeted therapy. We discovered that the hematopoiesis-restricted tetraspanin CD37 is expressed on the majority of primary AML …

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Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia

Jessica Judith Nunes, Rakeb Tafesse, Charlene Mao, Matthew Purcell et autres

Siglec-6 is a lectin receptor with restricted expression in the placenta, mast cells and memory B-cells. Although Siglec-6 is expressed in patients with chronic lymphocytic leukemia (CLL), its pathophysiological role has not been elucidated. We describe here a role for Siglec-6 in …

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Abstract 3165: Targeting angiogenesis for improved survival in mantle cell lymphoma

Satishkumar Vishram Singh, Anuvrat Sircar, Audrey Odier, Narendranath Epperla et autres

Abstract Mantle cell lymphoma (MCL) is a subtype comprising 6% of all NHL cases and is characterized by overexpression of cyclin D1 due to chromosomal translocation t(11;14) in the nodal MCL subtype. One of the best discriminatory genes between these conventional and …

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Abstract 2997: Identification of novel long non-coding RNAs in mantle cell lymphoma patients

Alessandro LaFerlita, Satishkumar Vishram Singh, Anuvrat Sircar, Robert A. Baiocchi et autres

Abstract Mantle Cell Lymphoma (MCL) is a rare and incurable type of B-cell non-Hodgkin lymphoma that affects about 4,000 people per year in the United States. Despite intense research to identify novel therapeutic approaches, the median progression-free survival after first-line treatment is …

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